Conserved Protein Domain Family
Glucosylceramide_synthase

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cd02520: Glucosylceramide_synthase 
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis.
UDP-glucose:N-acylsphingosine D-glucosyltransferase (glucosylceramide synthase or ceramide glucosyltransferase) catalyzes the first glycosylation step of glycosphingolipid synthesis. Its product, glucosylceramide, serves as the core of more than 300 glycosphingolipids (GSL). GSLs are a group of membrane components that have the lipid portion embedded in the outer plasma membrane leaflet and the sugar chains extended to the outer environment. Several lines of evidence suggest the importance of GSLs in various cellular processes such as differentiation, adhesion, proliferation, and cell-cell recognition. In pathogenic fungus Cryptococcus neoformans, glucosylceramide serves as an antigen that elicits an antibody response in patients and it is essential for fungal growth in host extracellular environment.
Statistics
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PSSM-Id: 133012
View PSSM: cd02520
Aligned: 26 rows
Threshold Bit Score: 205.524
Threshold Setting Gi: 7635885
Created: 7-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
ligand binding
Feature 1:ligand binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               # #                                                                      
AAH84966      51 PGVSLLKPLKGVDSNLINNLETFFELDYPk-fEILLCVQDLDDPAVDVCKKLLGKYPsVDAKLFIGgkkvginPKINNLM 129 African clawed ...
YP_827659     21 PPLSILKPVHGRDPQFYKAILSHATQEYPe-fEILFGTNNVEDPALPDIRRLQKEFPnRRIEIVIAnnd-apnAKVGVLE 98  Solibacter usit...
NP_680855     45 PAVSILVPVCGLEARAWQNWSSLCEQNYPv-yEVLFGVQSPNDPAIPVLQAICETYP-DRARWYLChpirginLKASNVS 122 Thermosynechoco...
ZP_00052843   50 PGVTILKPLCGLEPDLFENLESFCRQDYAgavQVVFGVQNAADPAIAVVERLRAAHPaLRLDLVVDasqhgsnRKVSNLI 129 Magnetospirillu...
YP_001520058  62 PPVTILKPLCGVDVNTYENLASFCHQDYAe-yQVIFSVREATDPCLPVVEQLILAFPdVDIELVVCdrtigtnLKVSNLA 140 Acaryochloris m...
YP_102370     44 EPVSVLKPLCGSEPHLYENLATFCEQRHPr-yQLLFGVASAADPAIAVVRRLQADYPdCDIELVIDarvygsnLKVSNLV 122 Burkholderia ma...
ZP_00415746   75 RPVSMLKPLHGAEPRLYENLRDFCRQTHPd-yQLIFGVREADDHAIAVVHRLCAEFPhLDIDLVIDprvhganLKVSNLL 153 Azotobacter vin...
EAY57375      58 PSILMIKPVKGLDEGARENFLSFLQQDYPe-yQILFVVGDGSDPVVELLRELQAEYP-EKVRFKIIfehsgtnRKMNNVN 135 Leptospirillum ...
YP_589803     61 PPVTLLKPVHGTEPQLKQNLESFFQQDYPd-fEIVFGARSLDNDAVRTVNELRKKYAhVKSSLIISgepewhnAKVYSLD 139 Acidobacteria b...
CAJ72742      41 EGISFLKPITGEVYNLYNNIKSFLDLRAIp-iEILFGVSSKDDPAYGILTKLENEFPgICKIILCSnhkkysnEKVGKLI 119 Candidatus Kuen...
Feature 1                        #                                                               
AAH84966     130 PGYEVAKydlIWICDSGIKVKPDTLtdmanq--mtekvGLVHGLpyvadrqgfaatleqvyf--gtshprsyisanvtgi 205 African clawed ...
YP_827659     99 ELAKLARfpvLLVNDSDIVVEPGYLhavtap-lanpgvGLVTCLyraaaqswparsealgia--tefapsvmvarllgva 175 Solibacter usit...
NP_680855    123 QLFAHARydvVVETDSDVRVRSNYLatltqp-ladpqvGVVTCGyidhqpqrlgaafvalgrcldfipsvlvarrldggl 201 Thermosynechoco...
ZP_00052843  130 NMSENIAhevVVLADSDMSVRPDYLerivaa-lsqpgvSGVTCLyhgvpgnrgvfaqlaalaidvqfvpnvilgtsfdla 208 Magnetospirillu...
YP_001520058 141 NGVEKAKhdvIVLADCDILVQSDYLqqivqp-lanpevGVVTCLynswakgwlagfealgit--trnhanvlaahklegm 217 Acaryochloris m...
YP_102370    123 NLAERARhgrIVIADSDIAVEPDYLtrvtap-ladpsvGVVTCLyharsvggfwtrigaqfv-dawfapsvrithlggss 200 Burkholderia ma...
ZP_00415746  154 NMLPLARhdwLVLADSDISVPADYLvrvtap-ladpgvGIVTCLyygvpqesfwsrlgalfi-ddwfapsvrlshvfgst 231 Azotobacter vin...
EAY57375     136 RAFEGEKgdlVLLNDSDIRVDPKYLksivrpmlddpsvGMVTCLqrgtpaggwssrlaslml-nteaipqalvayrlfpi 214 Leptospirillum ...
YP_589803    140 KMIQSTPnshFIITDSDIVVEHDFIrriipp-lndpkvGCVTAMykgvpapefwsrmealgm-svempsgvmvvdmlegm 217 Acidobacteria b...
CAJ72742     120 TLTEHARydiINISDADVLVPQDFLqslth----iknaGMVTNLyrgihnegigghleviti-lsdifqgvcmakifhgi 194 Candidatus Kuen...
Feature 1                                                                                   
AAH84966     206 kCVTGMSCLMRKEVLDQAGgliaFAQYIAEDYfmAKAIAdrgwkfsMATQVAMQNsgcysisqFQSRMIRWAKLR 280 African clawed frog
YP_827659    176 dFALGSTMVFRTEALERIGgfraIANYLADDYqlGRHIAqlgyrieFAPVVVETDlgggswgqIWRHQLRWSRTI 250 Solibacter usitatus ...
NP_680855    202 rFAIGPTVLLRREVLEKIGgfeiALNRIGEDYqlGYAAWragyrveLSTYILDNDcgndsllsAVQRELRWSRSI 276 Thermosynechococcus ...
ZP_00052843  209 rPCFGSTIAMTAESLARIGgfraFKDDLADDYaiGEALRaeggtvaIPTFTIGHAcvdtelagLWRHELRWNRTI 283 Magnetospirillum mag...
YP_001520058 218 hFAFGSTIVIRQAALAKIGgfaaLADHLADDFhmGNLPTqvgyqvvLSPYIVEHQlattnlseFFHRQARWARCI 292 Acaryochloris marina...
YP_102370    201 rFGFGATLALTRATLDAIGgfkaLKDELADDYwlAELPRrlglrtvLSEVNVATDvaepsfapLWLRETRWLRTI 275 Burkholderia mallei ...
ZP_00415746  232 rFAFGSTIALRREVLQAIGgfevLRDTLADDFwlGELTRraglrtvLSDLLVGTEvsetrlieLWTHELRWLRTI 306 Azotobacter vineland...
EAY57375     215 dFAFGPTMLLRRDALEKSGgfsaLTDILADDYhlAQNLVragykihLSPYLVDARigeespgdLWRHEIRWVRTY 289 Leptospirillum sp. G...
YP_589803    218 kFALGAVMAVRRDSLKSIGgiqaTREFYSDDFvlGNLISeagyevvLSDVKVGHVltsrsfakTFGDQLRWMQST 292 Acidobacteria bacter...
CAJ72742     195 nYGFGASMFLTKQSLESIGgyeaLGNMLADDYhlGNKISkngnpvtLSTILVNTVvgksnfknYFVRQLRLCKTY 269 Candidatus Kuenenia ...

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