1VPA,1W55,1I52,2PX7,1W77,1VGW


Conserved Protein Domain Family
CDP-ME_synthetase

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cd02516: CDP-ME_synthetase 
Click on image for an interactive view with Cn3D
CDP-ME synthetase is involved in mevalonate-independent isoprenoid production.
4-diphosphocytidyl-2-methyl-D-erythritol synthase (CDP-ME), also called 2C-methyl-d-erythritol 4-phosphate cytidylyltransferase catalyzes the third step in the alternative (non-mevalonate) pathway of Isopentenyl diphosphate (IPP) biosynthesis: the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol from CTP and 2C-methyl-D-erythritol 4-phosphate. This mevalonate independent pathway that utilizes pyruvate and glyceraldehydes 3-phosphate as starting materials for production of IPP occurs in a variety of bacteria, archaea and plant cells, but is absent in mammals. Thus, CDP-ME synthetase is an attractive targets for the structure-based design of selective antibacterial, herbicidal and antimalarial drugs.
Statistics
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PSSM-Id: 133009
View PSSM: cd02516
Aligned: 140 rows
Threshold Bit Score: 174.249
Threshold Setting Gi: 123065500
Created: 28-Oct-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site
Evidence:
  • Structure:1vpa_a; Thermotoga Maritima CDP-Me_synthetase bound to CTP and Mg++
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # ######            #                                                      
1VPA_A     14 NVAILLAAGKGERMSen------vPKQFLEIEGRMLFEYPLSTFLkseaidGVVIVTRrewfevvekrvfhekvlGIVEG 87  Thermotoga maritima
AAP56592   10 TVGIILASGSSSRIGlt-----dqLKQFYLVNNKMVYEYSLDQFLasnlfdLIYLVVNeqhlemikakhsdnhiiKVIVG 84  Mycoplasma gallise...
O25664     36 TSVVLLAAGESRRFSqt------iKKQWLRSNHTPLWLSVYESFKealdfkEIILVVSeldyiyi---krhypeiKLVKG 106 Helicobacter pylori
A6Q2K0      4 LTLVLLGAGNSSRFGld------vKKQWLWCGNEPLWLYVTNRFTdmfpfhDVVITAHpkeipfy----kkfchhTIVKG 73  Nitratiruptor sp. ...
A6Q7M3      4 ITLILLGAGNSTRFEsd------vKKQWLYSGEIPLWLHVAESFEamgafaKIVIVSSpediglm----khfadyTYVQG 73  Sulfurovum sp. NBC...
1W55_A      4 MSLIMLAAGNSTRFNtk------vKKQFLRLGNDPLWLYATKNLSsfypfkKIVVTSSnitymk-----kftknyEFIEG 72  Campylobacter jejuni
A8ER37      4 VTLIVLCAGNSTRFEhk------tKKQWIRVEDEPLWLNVTKRISsfakfdKIIVTSHqdelnym---knfsddfTFVKG 74  Arcobacter butzler...
Q30QG7     17 ITLILLAAGSSSRFEld------iKKQWLRVGDRPLWHFVADRCEktgyfdKIIITSSlddiefm----knyadyTFVEG 86  Sulfurimonas denit...
Q7VFU3      6 VSLIMMAAGDSTRFCasnaqtfrcKKQWLRVGEEPLWLVATRNLThhfsfkQVILTASskdyvym----qnispyKVVQG 81  Helicobacter hepat...
Q7MQW9      4 VSLVVMGAGESSRFRqgl----siKKQWLRLGETPLWKHVALHLSkqacfdQVIITASpkevkym----qkqvdfEVIEG 75  Wolinella succinog...
Feature 1     ## ##  #                      ###                                               
1VPA_A     88 GD-TRSQSVRSALeflek---fspsYVLVHDSARPFLRKKHVSEVLrra--retGAATLALKNSDalvrve--ndrieyI 159 Thermotoga maritima
AAP56592   85 SKiNRHLSFIHAIndliacgyddqtKIVVHDSARPNINQTILSDCLnal--dhyQCVSLYQDIASslikidqinqsqehL 162 Mycoplasma gallise...
O25664    107 GA-SRQESVRNALkii------dsaYTLTSDVARGLANIEALKNLFltlqqtshYCIAPYLPCYDtaiy------yneaL 173 Helicobacter pylori
A6Q2K0     74 AD-TRQQSLLNALemv------ktpYVLVSDIARPCIQKEVVQKIIdnr--skaACIVPYIQPADtvvy------knetI 138 Nitratiruptor sp. ...
A6Q7M3     74 GE-TRQASLKNALedv------tteYVLVSDIARCCVPAAMIHRILdar--eeaSCIVPVLPVTDtlyl------aqtpL 138 Sulfurovum sp. NBC...
1W55_A     73 GD-TRAESLKKALeli------dseFVMVSDVARVLVSKNLFDRLIenl--dkaDCITPALKVADttlf------dneaL 137 Campylobacter jejuni
A8ER37     75 GE-TRQLSILNSLqfv------ttkYVMITDVARACVPQSVIENLLnek--ssaDCIVPILNVTDtvvy------endtI 139 Arcobacter butzler...
Q30QG7     87 GQ-TRQQSLKNSLlhv------dteYVLVSDVARSCIDEAFLKKIIshv--gksDAVVPYLNITDtivy------ddktI 151 Sulfurimonas denit...
Q7VFU3     82 GQ-TRCQSLRNALkyv------dtpLVLVSDVARWDSSDSIIKTMLkald-esvACVVPFVGVADtsfy------egeyL 147 Helicobacter hepat...
Q7MQW9     76 GG-TRQESLQNALasv------ktpWVLVSDVARFDVPSEVISRVIgrl--geaECVAPAIGVSDtvsy------qgeyL 140 Wolinella succinog...
Feature 1                                                              #          
1VPA_A    160 PRKGVYRILTPQAFSYEILKKAHEngg---ewADDTEPVQKlg-vKIALVEGDPLCFKVTFKEDLELA 223 Thermotoga maritima
AAP56592  163 DRDQIKMIYTPQATWLKTVKDLVDdqqnhldlTDFLLKLKGv---KAHWIKTKIDCFKITTLADLEHF 227 Mycoplasma gallisepticum R
O25664    174 DREAIKLIQTPQLSHTKALQSALNqg----dfKDESSAILQafpdRVSYIEGSKDLHKLTTSGDLKHF 237 Helicobacter pylori
A6Q2K0    139 DRNEVKLIQTPQLSSTDILRKALTqgk---efTDESSAIQAlg-eKVFYILGNRKQHKLTYKEDMKLL 202 Nitratiruptor sp. SB155-2
A6Q7M3    139 DREQVRIIQTPQLSVTKTLKQALQtdq---lfTDDSSAVASmg-kKVHFVEGSHEAHKLTTISDLKKL 202 Sulfurovum sp. NBC37-1
1W55_A    138 QREKIKLIQTPQISKTKLLKKALDqnl---efTDDSTAIAAmg-gKIWFVEGEENARKLTFKEDLKKL 201 Campylobacter jejuni
A8ER37    140 DRSNVKLIQTPQLSSTQVLRDALNtpi---efTDESSAIKAid-gKIKYIQGSTFSKKLTLGDELDEL 203 Arcobacter butzleri RM4018
Q30QG7    152 DRERVKRVQTPQLSLTTALKSALLree---efTDESSAIVAng-gSREFILGQESAHKITHIEDLKKL 215 Sulfurimonas denitrificans DSM...
Q7VFU3    148 KRESIKLIQTPQLSRVEDLQEALKdts--kdfSDESSALYAlg-kKIAFVQGSELMNKLTFSSDLKAH 212 Helicobacter hepaticus ATCC 51449
Q7MQW9    141 SRSEVKLIQTPQLSHVESLLLAFRqg----dfTDESSAIAKsg-gRVLLVEGSERLKKLTHPHELTLL 203 Wolinella succinogenes DSM 1740

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