1FO8,2APC,2AM3,2AM5


Conserved Protein Domain Family
GT13_GLCNAC-TI

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cd02514: GT13_GLCNAC-TI 
Click on image for an interactive view with Cn3D
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides.
Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GLCNAC-T I , GNT-I) transfers N-acetyl-D-glucosamine from UDP to high-mannose glycoprotein N-oligosaccharide, an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localized to the Golgi apparatus. The catalytic domain is located at the C-terminus. These proteins are members of the glycosy transferase family 13.
Statistics
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PSSM-Id: 133007
View PSSM: cd02514
Aligned: 20 rows
Threshold Bit Score: 469.502
Threshold Setting Gi: 156397917
Created: 10-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substrate
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ### #                           ##                                        
1FO8_A         3 VIPILVIACDRs-TVRRCLDKLLHYrpSAELFPIIVSQDCGHEETAQVIASYg---sAVTHIRQPDLSNiavqpdh--rk 76  rabbit
Q11068        92 PIPVLVFSCNRamAVRDHVEKLIRYrpSQEKFPIIVTQDCDNENVKNEVKKFg---dKVEYIKHLAGDKanitippshrq 168 nematode
AAM69111      71 VAAVLVFCATRpdALRNHLSQILAQrpSHFQYHIIVSQDGNKTAVTQVAQKFvkdykNVSHIQHEKTEIkkrn------- 143 nematode
XP_001665083  79 PIPVLVFACNRpaAIRDHLEKLIRLrpSKESFPITVSQDCDSSKVADEVKKFg---dQVEYIKHTPGINanikvpprfkk 155 Caenorhabditis ...
2AM3_A         2 VIPILVIACDRs-TVRRCLDKLLHYrpSAELFPIIVSQDCGHEETAQVIASYg---sAVTHIRQPDLSNiavqpdh--rk 75  rabbit
AAF57454     119 VFPVVVFACNRv-SVKKCIDNLVQYrpSVEQFPIIVSQDCGDEPTKEAILSYg---kQVTLIEQPDLSDitvlpke--kk 192 fruit fly
EDP35472      41 DTVILVIACNRfeALKEHLESLKNL--QGPKIPIIVSLDCNDDAVRDIILNAg---pNITLIENPNQSLfnltkqe--kk 113 agent of lympha...
XP_001637848 159 ELPVAIIASNRphYLYRMIRSMLSAs-GADPKMVTVFIDGYFEEPLAVAKLF-----GLRGIQHTPISSkn--------- 223 starlet sea ane...
AAH84747     296 TVPVAVIAGNRpnYLYRMLRSLLSAq-GVSPQMITVFIDGYYEEPMDVVELY-----GLKGIQHTPISIkn--------- 360 African clawed ...
NP_001036152 296 NIPVAVIAGNRpnYLYRMLRSLLSSh-GVNPQMITVFIDGYYEEPMDVVDLF-----GLKGVQHTPISIkn--------- 360 zebrafish
Feature 1             ##  ##                    ###                                              
1FO8_A        77 fqgyyKIARHYRWALGQIFHNf-nYPAAVVVEDDLEVAPDFFEYFQATYPLLKaDPSLWCVSAWNDNGKEQMVDSskPEL 155 rabbit
Q11068       169 ytayyRIARHYKLALNHVFVDk-gYSSVIITEDDLDISPDFFSYFSSTRYLLEnDEKLWCVTAWNDNGKQENIDMtaAST 247 nematode
AAM69111     144 --nypAISAHYKWALDKAFKGf-rYDHVIVTEDDLDIGNDFFSYFRWGKQVLNsDDTIWCVSAWNDNGGGPLIDStrGDL 220 nematode
XP_001665083 156 kksyfYISRHYKLALTHMFSKn-pYSTVLITEDDLDIAPDFFSYFSSTRHLLEkDPNLYCVSAWNDNGKLEHIDWnaNAT 234 Caenorhabditis ...
2AM3_A        76 fqgyyKIARHYRWALGQIFHNf-nYPAAVVVEDDLEVAPDFFEYFQATYPLLKaDPSLWCVSAWNDNGKEQMVDSskPEL 154 rabbit
AAF57454     193 fkgyyKIARHYGWALNTTFAVg--FEFVIIVEDDLNVAPDFFEYFLGTHKLLKqDPSLWCVSAWNDNGKAAVVDAaqPEL 270 fruit fly
EDP35472     114 yegyyRIARHYHFALDYVFSIl-gYQSAIITEDDLLLAPDFLEYMLANKNLLFeDPTIWCISAWNDNGKKELIVKn-NSL 191 agent of lympha...
XP_001637848 224 ----aRISQHYKASLTTTFNLypkAEYMIIIEEDLDVSPDLFYYFQQLLPVMNdDGSVYCISAWNDQGYDHTVGD--NTM 297 starlet sea ane...
AAH84747     361 ----aRVSQHYKASLTATFNLhpdAKFAIVLEEDLDISVDFFSFLSQTIHLLEeDESLYCISAWNDQGYEHTAED--SSL 434 African clawed ...
NP_001036152 361 ----aRVSQHYKASLTATFNLhpdADFAIVLEEDLDISIDFFSFLGQTIHLLHeDDSLYCISAWNDQGYEHTAED--PSL 434 zebrafish
Feature 1                 #                         ##                               #  #        
1FO8_A       156 LYRTDFFPGLGWLLLAELWAEL-EPKWPK----AFWDDWMRRPEQRKGRACVRPEISRTMTFG---RKGv-SHGQFFDQH 226 rabbit
Q11068       248 LYRSDFFAGLGWMMSSKTWHEL-EPIWPV----GFWDDWMRDPARRKDRQCIRPEISRTGMMSy-gKEGa-SKGQFFSKH 320 nematode
AAM69111     221 IWRTDFFPGLGWMLTKKLWNEL-SPGFPV----AYWDDWMRKPEVRKSRSCIRPEISRTSHNMklaGKG--SSGGMFKDY 293 nematode
XP_001665083 235 LYRSDFFGGLGWMMARRQWEEF-EPTWPA----VFWDDWMRDPAQRKGRQCIRPEISRTGMMIh-gKKGv-SNGQFYADH 307 Caenorhabditis ...
2AM3_A       155 LYRTDFFPGLGWLLLAELWAEL-EPKWPK----AFWDDWMRRPEQRKGRACVRPEISRTMTFG---RKGv-SHGQFFDQH 225 rabbit
AAF57454     271 LYRTDFFPGLGWMLTKDLWAEL-SVKWPK----SFWDDWIRHPAQRKDRVCIRPEISRTRTFG---KIGv-SNGLFFDKY 341 fruit fly
EDP35472     192 LHRTDFFPGLGWMLTSQLWEEL-KVKWPK----TFWDDWMRDPAQRQGRACVRPEISRTGISLr-gKKGv-SKGLYYEKH 264 agent of lympha...
XP_001637848 298 LYRVETMPGLGWVLKRKMYKDElEPKWPTpdkfWDWDMWMRLPEIRKGRECIIPDISRTYHFG---TKGlnMHPLFQELY 374 starlet sea ane...
AAH84747     435 LYRVESMPGLGWVLRKNLYKDElEPKWPTpeklWDWDMWMRMPEQRKDRECLIPDVSRSYHFG---IVGlnMNGYFHEAY 511 African clawed ...
NP_001036152 435 LYRVESMPGLGWVLKKSLYKDElEPKWPTpeklWDWDMWMRMPEQRKGRECVIPDVSRSYHFG---IIGlnMNGYFHEVY 511 zebrafish
Feature 1                                                                                        
1FO8_A       227 LKFIKLNQQFVPFtqLDLSYLQqEAYDRDFLARVYGapqlqvekv----rtndrkelGEVRVQYTG---RDSFKAFAKAl 299 rabbit
Q11068       321 LAKIKVNDKYINFgkIDLDYLLpANFAKKTNLEVMKeavelsidnvasfvlssenkgKSVRVMYDG---NIDYIRKADKl 397 nematode
AAM69111     294 LSKISASSANIDFslLPVTLVQkSIYDKRLIEQIENarpidlqn------ttgmektYNYKIVYKN---IRDWHRLAAHf 364 nematode
XP_001665083 308 LSKIKMSNFSINFeeLNLNYLLpNNFKNKMDKDLADavlvelenit-ssswkpevknLKVKIVYTG---KAHFVNITKEl 383 Caenorhabditis ...
2AM3_A       226 LKFIKLNQQFVPFtqLDLSYLQqEAYDRDFLARVYGapqlqvekv----rtndrkelGEVRVQYTG---RDSFKAFAKAl 298 rabbit
AAF57454     342 LKHIKLSEDFVQFtkINMSYLLkDNYDNTFLRRVYTypivtydel----rrnlirieGPVRIQYTT---REQYKRTTKMl 414 fruit fly
EDP35472     265 LKHIIVNTDFYHFsqSDLSYLKkDYYDPAFRKIVLGavpatldeilrgrfsngtilpENVRLFYVA---SVDFKAFAKRf 341 agent of lympha...
XP_001637848 375 FKKHALNTEPNVK--LNTEVIKkDNYEKEIERLIGTavvldhnknpcnhsdfipdtqRQTYVFYMRmvnAVDWVTWKSI- 451 starlet sea ane...
AAH84747     512 FKKHKFNTVPNVQl-SNVKSLQkDAYEIEIHRILSEaevldhsknp-cedsfipdteGKTYIMYIKmeqEADFTTWTQL- 588 African clawed ...
NP_001036152 512 FKKHKFNTIPNVQm-KNVENLKkDPYEIEIQNLLREaevldhsknp-cedsfipdteGKTFVMFIKmeqETDTNTWTEL- 588 zebrafish
Feature 1                                           
1FO8_A       300 GVMDDLKsGVPRAGYRGIVTFLFRGRRVHLAPPQT 334 rabbit
Q11068       398 HIMHDFKaGVPRTAYDGIVTCFINGIRIYLVPDRT 432 nematode
AAM69111     365 KLMTDIRgGMQRTAYYGVVTLMFQNCRVFLVPEST 399 nematode
XP_001665083 384 GIMNEFRsGIPRTAYNGIVTCFFKKTRLFLVPDRS 418 Caenorhabditis briggsae AF16
2AM3_A       299 GVMDDLKsGVPRAGYRGIVTFLFRGRRVHLAPPQT 333 rabbit
AAF57454     415 GLMDDFKsGVPRTAYHGIVSFYYNKRRVHLAPNAN 449 fruit fly
EDP35472     342 GVMDDFRsGICRTCYHGVVSFRYGQHRVFLTPKEI 376 agent of lymphatic filariasis
XP_001637848 452 SKCLHIWdLDVRGFHKSMWRLWLKGNHILIVGTPA 486 starlet sea anemone
AAH84747     589 AKCLHIWdLDVRGNHKGLWRLFRKKNHFLVVGFPF 623 African clawed frog
NP_001036152 589 AKCLHVWdLDVRGYHKGLWRLFRKKNHILVVAFPI 623 zebrafish

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