Conserved Protein Domain Family
Beta4Glucosyltransferase

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cd02511: Beta4Glucosyltransferase 
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide.
UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.
Statistics
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PSSM-Id: 133005
View PSSM: cd02511
Aligned: 72 rows
Threshold Bit Score: 127.405
Threshold Setting Gi: 46399727
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative metal
Feature 1:putative metal binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
P44029        3 TISVAMIIKNEAQDLANCLDTVKdwvdEIIILDSGSTDNTKEIal-----syGAKFyensdwQGFGKQRQLAQQYVTSDY 77  Haemophilus infl...
NP_228566     5 LLSVAMIVKDEEHNIRRALESIKdvvdEIVVVDTGSTDRTPEIvr-----eyTDKLyfhewkNDFSEARNFSLKFPTCEW 79  Thermotoga marit...
CAJ73860      8 TISACLIVKNEERFLPNCLNSVKnavdEIVVVDTGSTDNTVNIak-----efSAKVyfyswnNNYSEARNYAIRHATKEW 82  Candidatus Kuene...
NP_622177    18 TLSLCLITKNEEKNISRCINSVKdivdEIVVVDTGSTDRTIEIak-----sfGAKViqikweDDFSKARNTAIESATGDW 92  Thermoanaerobact...
ZP_01103400   2 RLSLCMIVKDEAFFIEECLAAAAphvdEIVVVDTGSTDGTRDIaa-----ryADTLldfewiENFSAARNAGLAAATGDW 76  gamma proteobact...
P42460        9 QVSLCMIVRDEAELLPRCLASVKdqvdELIVLDTGSRDRTPAIat-----eaGAKLlhtdwaDDFSAARNQAIAAATGDW 83  Synechococcus el...
CAC98766      4 LISICMIVKNEAHILRQSLASFRkfteEIIIVDTGSTDETKEIaq-----efTDFVydfewtGNFSDARNFAAKHATGKW 78  Listeria monocyt...
NP_817067    69 EVSVCIIAKNEQDSIRKCINSIYefsdEIIFIDTGSIDLTKKIvkei--aseKVKIfdytwqDDFSDARNYSIQKASKEW 146 Enterococcus fae...
NP_683217     4 LLSLCMIVKNEAHQLRRCLQSVQpwvdEIIIVDTGSTDGTIAIac-----efTPHVhavawqGDFAAARNAALAQATGEW 78  Thermosynechococ...
ABD52018     71 TISAVYIVKNERDTLLKSLESLNgladEIIIVDTGSTDGTLEMlatpskndgSISLysfewcDDFSKARNFANSKANGDW 150 Streptococcus mu...
Feature 1           # #                                                                         
P44029       78 VLWLDADErvTPKLQQAILsavkndre-------ntvyeiprVSEVFGREirhsgw------ypdyvvRLYRTNYAqynd 144 Haemophilus infl...
NP_228566    80 VLILDADEeaSEEFRQNIRsfleslpe-------dvntvylpTVSYLDWDfkrte--------iastpRIFRNGTVyyk- 143 Thermotoga marit...
CAJ73860     83 ILMIDADEelEQNDIPVLKqsisnd-----------nyngviIAIYSKVKsgmhk---------fyntRVFRREKAfyk- 141 Candidatus Kuene...
NP_622177    93 ILFLDADEeiKKEDVSKIKsllyddt---------veaylfkFVNYAGSSinsglt------einynyRLFRNNGKlkyi 157 Thermoanaerobact...
ZP_01103400  77 ILVLDADEriAAEDYPRLReamattafdgfylttrnytsnttRSDFILATpddsmsrgyagyalhpimKLFRARDDirye 156 gamma proteobact...
P42460       84 ILVLDADEelILEAWTELRsqld---------------qpeaLAFTVLREetqagqv-----pysrlsRLFRNRPDirfq 143 Synechococcus el...
CAC98766     79 ILAIDADEclEEESYRKLEkqlkspt---------epiqmaqIISFTGEKgrvtt--------tnqmaRVYKNDGTicfr 141 Listeria monocyt...
NP_817067   147 ILIIDADEyvSSDELTKLRllidmld----------rfkfkdSLRVSCAIyqldnv------ithgqsRLFRNNNKikyy 210 Enterococcus fae...
NP_683217    79 VFYIDADEelVVTDAHWQDqltapg------------ahainQWSLLRREqssdrnw-----sefwnvRFGRRFPDlhfa 141 Thermosynechococ...
ABD52018    151 IISFDADEkiTDFKSLKLLltylqifg-------dypktvfnLNIVRDEItyk-------------tgKIIQNLPCfsyk 210 Streptococcus mu...
Feature 1                                                                                       
P44029      145 slVHEKVEFpagtkve---------kltgdleHFTYKSIHHyl-----------------vKSAGYAkawad-------- 190 Haemophilus infl...
NP_228566   144 niVHNQAVYkpkvvh-----------apfviyHYGYIWTRKl-------------------KKNKYErtatl-------- 185 Thermotoga marit...
CAJ73860    142 giIHEQVVIegkrlp-----------seihlyHYGYDLDEDt------------------mRKKWHRttqllekqialnd 192 Candidatus Kuene...
NP_622177   158 ypVHENLRNieenrppia------kkadvtilHYGYLADIRke----------------knKSERYIkl----------- 204 Thermoanaerobact...
ZP_01103400 157 ggVHEIVDGsivdsrrg--------tldaiihHYGEANPERpk----------------kdRALRYLsmmenepyfkedg 212 gamma proteobact...
P42460      144 rpYHELVDDsllalqqqepnwritawptpvirHYGYGRDRLqqrgtaermrqsletwladhPEDAYLcsklggl------ 217 Synechococcus el...
CAC98766    142 gvIHEQLEAidkrpiaa-------gvaevkiyHYGYMSEIVek----------------qdKSDRNLrlle--------- 189 Listeria monocyt...
NP_817067   211 glIHEELRNnkgldpifn------veseitffHDGYKEILRk------------------eKCERNIrllakm------- 259 Enterococcus fae...
NP_683217   142 gaLHEQLCYrereavvg-------elqgvyliHHNQQSQEQfl----------------akIRDRNIpile--------- 189 Thermosynechococ...
ABD52018    211 grVHETYFSavg------------------dvHYANIDIDIi-------------------SQNRTTse----------- 242 Streptococcus mu...
Feature 1                                                                                       
P44029      191 --------------------qrqaKGKKAtlwqgish--------------------------------algcfvkmYLL 218 Haemophilus infl...
NP_228566   186 -------------------ireqlKTVKNpiekiyyliq----------------------------lyktektggrKHE 218 Thermotoga marit...
CAJ73860    193 ndsfawlnlirnyctqqlfrdgikTGKEAlkritpeanl----------------------------hhfimilyemADC 244 Candidatus Kuene...
NP_622177   205 ----------------------isKYLEShpedkfqhan----------------------------laveyfnigdYQK 234 Thermoanaerobact...
ZP_01103400 213 rlls---magsaamyfaedyakanRYLRRaaelgyepsrslega-------------------aeaayrhgnygeaqDLY 270 gamma proteobact...
P42460      218 -----------------lvqegdlKAAQRwlkqglkqg------------------------------rpepavryeLLY 250 Synechococcus el...
CAC98766    190 --------------------kevkNNKNSgfvhfnigqe----------------------------mnrlgnkkeaLKE 221 Listeria monocyt...
NP_817067   260 ------------------lekepdNVRWAylycrdsfsinanidfekillpfliknmdesisyenilltnythlilfLIT 321 Enterococcus fae...
NP_683217   190 --------------------tmvqQGDRRlqnlvclgdhya-------------------------acgdsdrsqawYEQ 224 Thermosynechococ...
ABD52018    243 ----------------------kvEYYNRlllltikd--------------------------------eplnlrwlYLY 268 Streptococcus mu...
Feature 1                     
P44029      219 KAGFLDGKQGFLLA 232 Haemophilus influenzae
NP_228566   219 ENRIAWETLQEIMK 232 Thermotoga maritima MSB8
CAJ73860    245 YLNTGNTAEAKKMC 258 Candidatus Kuenenia stuttgartiensis
NP_622177   235 ALKHLLIATKGMDV 248 Thermoanaerobacter tengcongensis MB4
ZP_01103400 271 RRLYDDGQRTTSLC 284 gamma proteobacterium KT 71
P42460      251 HLALLERRQGDLDA 264 Synechococcus elongatus PCC 7942
CAC98766    222 FSEAFRLRDHNHYI 235 Listeria monocytogenes
NP_817067   322 KKYIIDGKSSLASK 335 Enterococcus faecalis V583
NP_683217   225 ALEEIASAVEQGIL 238 Thermosynechococcus elongatus BP-1
ABD52018    269 LRDNFDSIKYTQMK 282 Streptococcus mutans

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