1XHB,2D7I,2FFU


Conserved Protein Domain Family
pp-GalNAc-T

?
cd02510: pp-GalNAc-T 
Click on image for an interactive view with Cn3D
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans.
UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.
Statistics
?
PSSM-Id: 133004
View PSSM: cd02510
Aligned: 40 rows
Threshold Bit Score: 385.789
Threshold Setting Gi: 38505153
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Mn binding siteligand binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Mn binding site
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1XHB_A     32 SVVIVFHNEawSTLLRTVHSVINrsprhmIEEIVLVDDASErdflkrple------syvkklkvpVHVIRMEQRSGLIRA 105 house mouse
Q8MYY6    113 SVVISFHNEarSMLLRTIVSLLSrspedyLHELILVDDGSQrdvtllddlkrwmggvfgsryrlgLTFLRNQERMGLIWS 192 fruit fly
Q8IA43    170 TVIIAFHDEhlSVLLRSITSIINrspvelLKQIVLVDDDSNlpelgqqlee-----ivaqnfpkiIHILRLPERRGSIKA 244 fruit fly
Q9VUT6    131 SVVITYHNEeaSVLLRTLSSLRSrtpiqlLREVILVDDGSTqadeklndf-------ikikflnmVQHRRITTQVGLMHA 203 fruit fly
AAO13781  113 SIVIAIQQEhpHTLLRGIYSVITqtspylLKEIVLVHDGHPdldlirh----------ihhklpiVIQLEMESSKGIIHA 182 fruit fly
Q8IA42    196 SVIFIFFNEhfNTLLRSIYSVINrtppelLKQIVLVDDGSEwdvlkqpldd-----yvqqhfphlVTIVRNPERQGLIGA 270 fruit fly
Q8N3T1    194 SVILCFHDEawSTLLRTVHSILDtvprafLKEIILVDDLSQqgqlksals-------eyvarlegVKLLRSNKRLGAIRA 266 human
O45293    110 SVVVIHHNEalSTILRMINGIIEftpkslLKEIVLYEDASEedhvltkhlek---fakikgledkLIIKRSEYRQGLIRA 186 nematode
AAQ95176   47 SLIIPIRDEd-EFISKTISFTLGlnnknlLKEIIVVDDCSKrevsdllnk------elpssylkyIKVIRLDKCEGLIRS 119 Cryptosporidium pa...
AAM95450  155 SVIIPVRNEe-AYLPKTLTFLFEvtpierIREVIVVDDHSDkpikailek------tlpqhildkTRVIRFDSPQGLIRG 227 Toxoplasma gondii
Feature 1                     # #                                                             
1XHB_A    106 RLKGAAVSrgQVITFLDAHCECTAGWLEPLLARIKhdrrTVVCPIIDVIsddtFEYMAGsdm-tyGGFNWKLNFRWYpvp 184 house mouse
Q8MYY6    193 RNRGASLAsgRYVLFLDSHCEVNEGWLEPLLERLAlntnLAVSPLLDPIdpttLSYRKGnel-lkGGFDWSLHFHWLkrq 271 fruit fly
Q8IA43    245 RMEAIRVSscQVLVFLDSHIEVNTNWLPPLLEPIVinphIVTRPILDAIsrktFAYAKQntm-trSGFNWWLESESLpif 323 fruit fly
Q9VUT6    204 RVVGAELAlaDVLVFLDSHVEVTKGWLEPLIAPILednrTCTTPIIDTIdfdnFAYRRGkp--srGFFNWEFNYIQLpll 281 fruit fly
AAO13781  183 RLTGAGVAtgDILVFLNGHMEVTRGWLPPLLEPILlnnqTVTEPIVDAIsresFAYRKLvep-eqLAFDWQLDHIFLpld 261 fruit fly
Q8IA42    271 RIAGAKVAvgQVMVFFDSHIEVNYNWLPPLIEPIAinpkISTCPMVDTIshedFSYFSGnkdgarGGFDWKMLYKQLpvl 350 fruit fly
Q8N3T1    267 RMLGATRAtgDVLVFMDAHCECHPGWLEPLLSRIAgdrsRVVSPVIDVIdwktFQYYPSkdl-qrGVLDWKLDFHWEplp 345 human
O45293    187 KVHASRLAtgEVIVFMDSHCEVAERWLEPLLQPIKedpkSIVLPVVDLInpvsFDYSPSmv--akSGFDWGFTFKWIylp 264 nematode
AAQ95176  120 RILGADASksSVIVFMDGHCRPKENWIEPLINRLKekpkAIVCPMIEDIdrytWKDLGTfg--lkMMFDWNFEFNWYed- 196 Cryptosporidium pa...
AAM95450  228 RVAGAAIAtsDNFFFLDGHCRPKVGWAEPLLAHLKtnyrRIACPKIYDIyldsWEDVGThg--tkMMFEWTFEFGWFed- 304 Toxoplasma gondii
Feature 1                                                                             #       
1XHB_A    185 qremdrrkgdrtlPVRTPTmaGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFR---- 260 house mouse
Q8MYY6    272 ltn----qeslemPYQSPAfaGGVLMMSREWFLKLGSFNPYLKIWGGESIELAIKLWLCGGQIEIVPCSRIGHIFR---- 343 fruit fly
Q8IA43    324 ped----kspdstPYRTPVl-SGAMAIDRNYFLNLGGFDEQLDTWEAEKFEISFKVWMCGGMMLYVPCARVGHIGKr--- 395 fruit fly
Q9VUT6    282 kee----avampaPHKNPImnGGLFAIGREWFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRdg-- 355 fruit fly
AAO13781  262 qhs----wnslpkPYPSSQleGRVFAIDRKWFWHLGGWDEGLRDYGGDALELSLKVWQCGGLILAVPCSRVGIIYKrdel 337 fruit fly
Q8IA42    351 ped----aldksmPYRSPVmmGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRg--- 423 fruit fly
Q8N3T1    346 ehvrk-alqspisPIRSPVvpGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQnq-- 422 human
O45293    265 weyfe-tpennvkPFNSPAmpGGLLAMRKEYFVELGEYDMGMEIWGSENIELSLKAWLCGGRVVVAPCSRVGHVFR---- 339 nematode
AAQ95176  197 ------------fTDVIPIasGGLYAITREWWEESGKYDPGMLEWGGENIEQSIRIWRCGGEIVAEKKSRVGHIFKr--- 261 Cryptosporidium pa...
AAM95450  305 ------------lEDEVPVlaGGILAMTKKWWIESGLYDEGMLEWGGENLEQSIRSWLCGGEIVAVQESKIGHIFSr--- 369 Toxoplasma gondii
Feature 1                                                                                     
1XHB_A    261 --KATPYTFpggtg-------qiinkNNRRLAEVWMDEFKNFFYIispgvtk-----vdygdiSSRLGLRRKLQCKpFSW 326 house mouse
Q8MYY6    344 --RRHAFDFppqsdrqlspaqetylhNSKIIAESWLDEYKNMFYAlrpaarr----ipldhtyDELQRMRKERRCHpFEW 417 fruit fly
Q8IA43    396 --PMKSISSpgyhn--------flarNYKRVAEVWMDNYKKYVYDknpklyk----managllFQRKTKRNALECKtFDW 461 fruit fly
Q9VUT6    356 -nFQIRYTNkdknse-----kklisrNYRRVAEIWLDEYKDKLFAnmphltv-----ipvgnlAEQRDLKNRLHCKpFKW 424 fruit fly
AAO13781  338 eaQMAPNRNpslq----------vqkNFKRVVDVWLDEYKLHFYRynpklrn-----ltaeslDKPRDLRRRLNCKsFEW 402 fruit fly
Q8IA42    424 --PMKPRGNprghn--------fvakNHKRVAEVWMDEYKQYVYKrdpktyd----nldagdlTRQRGVRERLKCKsFHW 489 fruit fly
Q8N3T1    423 -dSHSPLDQeat------------lrNRVRIAETWLGSFKETFYKhspeafsl--skaekpdcMERLQLQRRLGCRtFHW 487 human
O45293    340 --MRRPYTSkpgmd--------talyNAVRVAKTWLGEYESKFFAvkprgak-----mvfgdlTEPMQVKDRLKCKdMKW 404 nematode
AAQ95176  262 --DPKPNPEnklvl--------qvqrNQKRAAMVWLDKKRYKYFEtihdvvkslnetqsgvdlEQRHSIKERLKCKpFSW 331 Cryptosporidium pa...
AAM95450  370 --PPKPNPGnrlvi--------qvqkNQKRGAKVWLDEYYFLFYKyhrevrg----hqegditQRKKLRYEQLTCMpFQW 435 Toxoplasma gondii
Feature 1           
1XHB_A    327 YLENIY 332 house mouse
Q8MYY6    418 YLRHVS 423 fruit fly
Q8IA43    462 YMTKVA 467 fruit fly
Q9VUT6    425 FLDNLA 430 fruit fly
AAO13781  403 YRSQVA 408 fruit fly
Q8IA42    490 FMTEVA 495 fruit fly
Q8N3T1    488 FLANVY 493 human
O45293    405 FIENVY 410 nematode
AAQ95176  332 YVDKFR 337 Cryptosporidium parvum
AAM95450  436 YVEKFK 441 Toxoplasma gondii

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap