2CU2,2QH5


Conserved Protein Domain Family
GDP-M1P_Guanylyltransferase

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cd02509: GDP-M1P_Guanylyltransferase 
Click on image for an interactive view with Cn3D
GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose.
GDP-mannose-1-phosphate guanylyltransferase, also called GDP-mannose pyrophosphorylase (GDP-MP), catalyzes the formation of GDP-Mannose from mannose-1-phosphate and GTP. Mannose is a key monosaccharide for glycosylation of proteins and lipids. GDP-Mannose is the activated donor for mannosylation of various biomolecules. This enzyme is known to be bifunctional, as both mannose-6-phosphate isomerase and mannose-1-phosphate guanylyltransferase. This CD covers the N-terminal GDP-mannose-1-phosphate guanylyltransferase domain, whereas the isomerase function is located at the C-terminal half. GDP-MP is a member of the nucleotidyltransferase family of enzymes.
Statistics
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PSSM-Id: 133003
View PSSM: cd02509
Aligned: 63 rows
Threshold Bit Score: 275.995
Threshold Setting Gi: 68195211
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Substrate
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Substrate binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             # #                                                                        
2CU2_A         3 TYALVMAGGRGERLWPLSREDRPKPFLPLfeg----ktLLEATLERLAplvppeRTLLAVR-RDQEAVARPya-----dg 72  Thermus thermop...
EAN09666       1 MNIVLLSGGSGKRLWPLSNDIRSKQFIKIfktedgyesMVQRVYRQIKkvdkdaTVTIATS-KTQVSAIHNhlg----ed 75  Enterococcus fa...
YP_056385      2 QHILILAGGSGTRLWPLSHQGEPKQLLELidg----vsLLRMAYERVAglvpdaNILVCTG-SSYADTVAKllpe--vpa 74  Propionibacteri...
XP_759087    289 LWAVVPAGGAGTRLWPLSRESYPKFLLDLtgs---grtLLQSTWDRLLplagqaQMMIVTG-QAHVGGVSAqlpd--leq 362 Ustilago maydis...
NP_444235      5 VAAVLLAGGTGTRLYPASRSHRPKQLLALgdd---drsLLRRTADRAAfa---dDLLAVTR-EAYADRVRDev-----pe 72  Halobacterium s...
ZP_01306305    4 IYPIILAGGMGTRLWPLSREEYPKQCLPLnde---hwsLLQQTLLRTQglqdcaPITVICH-EQHRFLVAEqclqtgvkh 79  Oceanobacter sp...
EDK72666      17 MIVVIIAGGSGTRLWPLSTSDYPKHLLQLmdn----dsLLQSTYKRAKkl--skHIYVQTAgEEQLKLVREqlpe--lgd 88  candidate divis...
YP_001547579   1 MDILVLAGGTGSRLWPRSRRTKPKQFLPLlsn----rtMLQETVDRVRplieegRVFVVTG-SDYEELIREqlnd--vpr 73  Herpetosiphon a...
EDP75585       1 MKSIILAGGRGTRLFPLSRKELPKQFVRLgn-----rsLFQRTLERHSd----fPVYVSLK-EDYTSLAKEqaee-vgig 69  Hydrogenivirga ...
NP_787484      6 LYSVIPAGGIGSRLWPLSRAASPKFLHKLtgt---etsLLRDTWDRLVpisgvdRIMVVIG-SDHFDAVTSqlpe--lkg 79  Tropheryma whip...
Feature 1                                                  #                                     
2CU2_A        73 IRLLLEPLGRDTAGAVLLGVAealk------egaeRLLVLPADHYVgddeAYREALATMLEAAe--eGFVVALGLRPTRP 144 Thermus thermop...
EAN09666      76 VCVSVEPCRRDTFPAIALATAylvdvm--gvnpeeSVVVCPVDPYVe--dDYFEALKSLSDQAdkgeANLVLMGIEPTYP 151 Enterococcus fa...
YP_056385     75 ENILGEPVGRDSLSAVAWPAGiiadr-----dpdgVMAVVTADHIIrpvdDFRAALQHGFDLAntdpTALVTFGVVPTEP 149 Propionibacteri...
XP_759087    363 ANVLAEPSPKESMAAIGLAAAvllqr-----dpeaVLGSFAADHIIsgrdAFESAVTEAVATAk--aGYLVTIGIAPSHP 435 Ustilago maydis...
NP_444235     73 ATVLVEPAGKDTGPALAYAASevrar----fgedaVMLCLPSDHVVg--dGFQETAETAVDVAar-tDGLVTIGIEPDRP 145 Halobacterium s...
ZP_01306305   80 FPILLEPEARNTAAAIASAVAfllaqdsvkadkdaVFCCLPADHAIeqsdAFITSLNQAVQLAreysQSLLTLGIEPTSA 159 Oceanobacter sp...
EDK72666      89 DAFPIEPARRDTAGAFIAALAhvqar----hdhdePIALIAADHYTrdvqGFVQSFKIAEKASrd-eGRICLVGIEPTYP 163 candidate divis...
YP_001547579  74 NNVILEPSGRGTASAIGLAAIhmrrs-----apdaVMAVLSADHLIlrneAFRQALQAAEVAAr--eGYLVTLGVKPSFA 146 Herpetosiphon a...
EDP75585      70 ANLIKEPSPKNTFPAIVWSLYvmriey--glkdddIVAVVPADQYIepveTYREDLSLARECAk--gGYVVLFGVKPNRP 145 Hydrogenivirga ...
NP_787484     80 HNVILEPEPKDSTAAICLAAAilntr-----epdvIIGSFPADHVIktspLFQQSVAQAVVAAn--eGYVVTIAITPTEP 152 Tropheryma whip...
Feature 1                                                                                        
2CU2_A       145 ETEYGYIRLGprega------wyrgEGFVEKPSYAEALEYIr-kGYVWNGGVFAFAPATMAELFRRHlpSHHEALerlla 217 Thermus thermop...
EAN09666     152 SEKYGYIIPEsakq-------tafvNTFKEKPTEAVAKEYIt-qGALWNGGVFAYKLKYVMERAHQLidFVDYQDl---- 219 Enterococcus fa...
YP_056385    150 NTGFGYLHRGgrlrpg---srahqvLEFVEKPSAEVARQYLdsgEYWWNSGMFVWRAATLLDCLSQLkpQTRHHVdelva 226 Propionibacteri...
XP_759087    436 STGFGYIKLGekldvse-apnarrvTEFKEKPDARTASAYLstgDYRWNGGMFVVKAQVLLDLLKGTvpELHEGLtriaa 514 Ustilago maydis...
NP_444235    146 ATGYGYIEPGddhgd------hsevAVFREKPDAETASRLVd-rGCLWNAGMFAWTPTAFLDAARSGplDPLVDAlatd- 217 Halobacterium s...
ZP_01306305  160 HTGYGYIQAGepvsteeypkagfkvQHFKEKPDAQTAQSYLeqgNYYWNAGIFMGTACAWQSAFTVYqpELWQHAkntlq 239 Oceanobacter sp...
EDK72666     164 ATGFGYIQKDgqlegs---slvynvMMFKEKPDFDTAKKYVqsgEYLWNASYFIGSVNTFLRTMEEYapELKKNYerlva 240 candidate divis...
YP_001547579 147 NTGYGYIQCGeliteah-nhkihrvQRFAEKPDHDTAERYLaqgNYFWNAGIFVWQTKTFLDAIGRHmpELRNQLnqvqa 225 Herpetosiphon a...
EDP75585     146 DTGFGYIKLGkkldk------afrvEEFTEKPSYEKALEYVksgKYLWNSGIFVFSFKTFEEECKLYqpFAYKLLntksr 219 Hydrogenivirga ...
NP_787484    153 ATQFGYILCGdsagikg-apqvlsvKRFVEKPSQKDADRYLssgKYLWNAGMFIAKACVLLEQLEKArpDIHSLIidian 231 Tropheryma whip...
Feature 1                                                                   
2CU2_A       218 --------gasleEVYAGlPKISIDYGVMEKAERV------RVVLGRFPWDDVGNWRAL 262 Thermus thermophilus HB8
EAN09666     220 ------------fNKYETlTKISFDYAVVEHEDKI------QVQRFAGMWKDLGTWNTL 260 Enterococcus faecium DO
YP_056385    227 d-------psrlaEVYPCmEKVSVDIAVMEPASHGgcgvhvAAIPLEIQWYDVGSYEAL 278 Propionibacterium acnes KPA171202
XP_759087    515 swds-dardtvmsEVWPTlPKIAIDHAVAEPASKVgk---vAVVPATFGWDDVGDFASL 569 Ustilago maydis 521
NP_444235    218 ---------adpaTAFERvDPVSVDYAVLERAADV------RVVPAAFDWDDLGAWNAL 261 Halobacterium sp. NRC-1
ZP_01306305  240 qaqadldflrlssEQYSLlPCMPFDVAIMEQLSNA------FMVSLDAGWSDLGEWQAL 292 Oceanobacter sp. RED65
EDK72666     241 tk-----srkeyeEVFLSfDKISIDYAMMDHTKDL------LVVPAAFDWADLGSFADA 288 candidate division TM7 genomosp. GTL1
YP_001547579 226 sfgk-sryhdtlaHVWENvENITVDYGIMERAPNV------AVVPVDIGWSDVGDWHTL 277 Herpetosiphon aurantiacus ATCC 23779
EDP75585     220 ---------dealYVFNKlQSEPIDKAIMEKSKRT------VCIPFRANWSDVGTFKGL 263 Hydrogenivirga sp. 128-5-R1-1
NP_787484    232 sp----dldsalkKNWPKmPRIAIEYSVAEPCAAEgr---mVTVPAKFEWNDAGDFSSI 283 Tropheryma whipplei str. Twist

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