1YP4,3BRK


Conserved Protein Domain Family
ADP_Glucose_PP

?
cd02508: ADP_Glucose_PP 
Click on image for an interactive view with Cn3D
ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch.
ADP-glucose pyrophosphorylase (glucose-1-phosphate adenylyltransferase) catalyzes a very important step in the biosynthesis of alpha 1,4-glucans (glycogen or starch) in bacteria and plants: synthesis of the activated glucosyl donor, ADP-glucose, from glucose-1-phosphate and ATP. ADP-glucose pyrophosphorylase is a tetrameric allosterically regulated enzyme. While a homotetramer in bacteria, in plant chloroplasts and amyloplasts, it is a heterotetramer of two different, yet evolutionary related, subunits. There are a number of conserved regions in the sequence of bacterial and plant ADP-glucose pyrophosphorylase subunits. It is a subfamily of a very diverse glycosy transferase family 2.
Statistics
?
PSSM-Id: 133002
View PSSM: cd02508
Aligned: 50 rows
Threshold Bit Score: 182.742
Threshold Setting Gi: 47459233
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
ligand bindingoligomer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site
Evidence:
  • Structure:1YP4,potato ADP glucose pyrophosphorylase in complex with ADP-glucose defined by 3.5 A.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1           # ##                                                                         
1YP4_A        23 GIILGGGAGTRLy-pLTKKRAKPAVPLgANYRLIDIPVSNCLNSNISKIYVLTQFnsASLNRHLSRAYASnmggyknegF 101 potato
O08327         7 GVIDATTYIEALe-pLIEQRSIAAVPFaGRYRLIDFVLSSMVNSGIESVAIFPKYqyRSLMDHLGSGKNWdlnr--krdG 83  Geobacillus ste...
P39124         8 GVIDETTYKHSLq-dLTAQRSLGAIPFaGRYRLIDFMLSNMVNADIRSVAIFPKYryRSLMDHLGAGKEWdlhr--kkdG 84  Bacillus subtil...
ZP_02037188    7 GIIFAYRSNADLr-eLTQVRNTCSVPYgGRYRTIDFMLSNFVNAGMVDVGIIVHAnyQSLLDHLGSGKDWdlsr--khgG 83  Bacteroides cap...
BAB04805       6 GVVNLDHDQDLLh-eLTYFRSVAGVPFgGRYRMIDFVLSNMVNSGIQDIAVFARNkyRSLMDHLGTGAPWdlnr--krgG 82  Bacillus halodu...
ZP_01665841    6 GLINLHEPEEKAlaeLTGHRPLAAVPFgGRYRLIDFALSNMVNSGIRNVGILFKQkyRSLFDHLRSGKDWdlar--khgG 83  Thermosinus car...
ZP_01189044    6 GIIDDTQEDSFLk-dLTFHRSVASVPFgSRYRLIDFILSNMVNSGIRNIGILVKNkhRSLLDHLGPGKEWdldr--krdG 82  Halothermothrix...
AAK80195       7 SILSLNENDNDIk-sLTKARPLASIPIaGRYRIIDFILSNLVNSGVKNIGILTQCksRSLLDHLGSGKPWdldr--klnG 83  Clostridium ace...
BAB79775       6 GIINLDENESKIg-eLAKNRPLAAVPIaGRYRIIDFILSNMTNAGIESLGILSKNksRSLVDHLTNGRPWdlhr--krdG 82  Clostridium per...
YP_001087357   7 GIINLNKKGDPAinkLNYGRPIASTPIaGRYRIIDFALSNMINSGITKVGIFAKEkyRSLTDHIGSGKDWdlsr--kkgG 84  Clostridium dif...
Feature 1                          # #                       ##                                  
1YP4_A       102 VEVLAAQQspe--npDWFQGTADAVRQYLWLFEEHtvlEYLILAGDHLYRMDYeKFIQAHRETDADITVAALpmdekrat 179 potato
O08327        84 LFFFPSPDllf--sgERRVGAFAHFEQHIDYFLRSrqkYAVIANGYTVCNIDFdAVLNRHIENGCDVTEIRHr------- 154 Geobacillus ste...
P39124        85 LFFFPSPHlh---heYDEFGSFRQFSDHLDYFHRStqqYAVISNSHTVCNIQFqYVLKRHQEVGCDVTEVFQd------- 154 Bacillus subtil...
ZP_02037188   84 LRILPPFGyankqrgGVCRGRMDALEGVYSYLTKIkqeHVVLAGGDIAVNLPMrEIYEQHIKSGADITAVCTrnpkgdpr 163 Bacteroides cap...
BAB04805      83 LFILPPDWnd---ptDISKGDLRHFHNHRDFFHRGnadHVLVSGSQFISKVDYeDAFKRHQETKADVTVLYKkvdqlepe 159 Bacillus halodu...
ZP_01665841   84 LIMLPPSDh------ADDRGDLGNFFANLEFIRRShepYVAVSGTATVCNIDLrEALAVHRAHSADLTIVYCeqprpkdc 157 Thermosinus car...
ZP_01189044   83 LFLLPPAQnn---ghHNSNSNIPFFKDNLDYLYNSrqeYVIFSSTNIIYNLNFkEVFSKHKKMGADLTIISHdipddrds 159 Halothermothrix...
AAK80195      84 LFIFNFSGi------TSTLSDIEMLKSNMEYLYRStqeKVILSSSAVICNIDFqRAAEFHEKSGKDITLIYKrtnngkrk 157 Clostridium ace...
BAB79775      83 LRVFNFGEr------DPYYDDITNLYENLEFLTKSrreYVIMSPSYMICNIDLkEALEYHKKNDNDITVIYKkvkdadsn 156 Clostridium per...
YP_001087357  85 LSIFSPENtkyrntySHREGDIYTILANLDYIEKSeeeYILIAPSYMLCNLNYsQALEYHKKSHNDITIIYKnvnnankd 164 Clostridium dif...
Feature 1                                                                                   # ## 
1YP4_A       180 afglmkideegriiefaekpqgeqlqamkvdttilglddkrakempfiASMGIYVISkdVMLNLLrdkf--pganDFGSE 257 potato
O08327       155 -----------------------------------------------gRSLEMYLLEtsLLLDLIadyk--nhgyYSIVD 185 Geobacillus ste...
P39124       155 -----------------------------------------------gQSLQIYIMSttLLKDLIyghs--ekgyKTIQE 185 Bacillus subtil...
ZP_02037188  164 ssdyftvgd----------------------dgritdvsvhpyapvgcESLEVYILSksLLLSLVdncaa-hnipSFSQG 220 Bacteroides cap...
BAB04805     160 dryrmklef----------------------dsfgnvksitndemnsnLYMQMYIIRkeLLLELLnhcigyhkqdLFVDG 217 Bacillus halodu...
ZP_01665841  158 adttyeltida------------------dgrvkdvalatsssgkrinIPLNMFILTkdVLIDLVtagsargdycFFHHG 219 Thermosinus car...
ZP_01189044  160 nylylktsk-----------------------qgwiteltdnpdngskISLETYILKksLLIDIIdycis-hnkkDFVRD 215 Halothermothrix...
AAK80195     158 flncsvlnmdk-------------------nnnvisigkntglddvqnISLGMFIMNkkLLINILnncir-tgfsLSLKQ 217 Clostridium ace...
BAB79775     157 fidcdvlnfde-------------------cgfiksigknlgreeesnISLEMYILRtdLLIEIIyecir-rgshRKFKS 216 Clostridium per...
YP_001087357 165 fagnltlnlds-------------------nnrvinvgnnlgkfpranICMETYIMKreDFVECIynivn-kgnyCYLEE 224 Clostridium dif...
Feature 1                                
1YP4_A       258 VIPGATSlgmRVQAYLYdGYWEDI 281 potato
O08327       186 VIRDYHRs-lSICEYEYsGYAAVI 208 Geobacillus stearothermophilus
P39124       186 AVEKESSa-lTICPYEYsGYAAVI 208 Bacillus subtilis subsp. subtilis str. 168
ZP_02037188  221 VLQSMVHt-lKIVPYIFdGYAARI 243 Bacteroides capillosus ATCC 29799
BAB04805     218 IMSNLNEl--AIRAYEYkGYLSII 239 Bacillus halodurans C-125
ZP_01665841  220 IIQKLPRl--KAYAYRFlGHVAHI 241 Thermosinus carboxydivorans Nor1
ZP_01189044  216 GIAHYLGk-lRAYAYHHnGYAGII 238 Halothermothrix orenii H 168
AAK80195     218 CIRKHMNn-fTVNAYEFnGYAEYI 240 Clostridium acetobutylicum ATCC 824
BAB79775     217 YLKEFLDe-iKVGGFEFkGYLSCV 239 Clostridium perfringens str. 13
YP_001087357 225 FIIEEAEn-mKIGAYEYtGYLKCV 247 Clostridium difficile 630

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap