Conserved Protein Domain Family
eIF-2B_gamma_N_like

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cd02507: eIF-2B_gamma_N_like 
The N-terminal of eIF-2B_gamma_like is predicted to have glycosyltransferase activity.
N-terminal domain of eEIF-2B epsilon and gamma, subunits of eukaryotic translation initiators, is a subfamily of glycosyltranferase 2 and is predicted to have glycosyltranferase activity. eIF-2B is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, generating active eIF2.GTP complex. EIF2B is a complex multimeric protein consisting of five subunits named alpha, beta, gamma, delta and epsilon. Subunit epsilon shares sequence similarity with gamma subunit, and with a family of bifunctional nucleotide-binding enzymes such as ADP-glucose pyrophosphorylase, suggesting that epsilon subunit may play roles in nucleotide binding activity. In yeast, eIF2B gamma enhances the activity of eIF2B-epsilon leading to the idea that these subunits form the catalytic subcomplex.
Statistics
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PSSM-Id: 133001
View PSSM: cd02507
Aligned: 44 rows
Threshold Bit Score: 134.688
Threshold Setting Gi: 23488910
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_065098      3 FQAVVMAVGg--GSRMTDLTSs------------------------------------------iPKPLLPVGNKPLIWY 38  human
EAU91280      15 FLAVLIAGF---GNELLPLTSdhgd-------------------------------------epyPKALLPVANKPLLEY 54  Coprinopsis cin...
P09032         3 IQAFVFCGK---GSNLAPFTQpdfpfqtqnkdstaatsgdklnelvnsaldstvinefmqhstrlPKALLPIGNRPMIEY 79  baker's yeast
AAW45625      19 FQAVILVGY---GENLYPFNQgtn---------------------------------------viSKALLPVGNVPIINC 56  Cryptococcus ne...
EAK89547      14 FKGVIFAGGs--GRMLGPLAKn------------------------------------------iSKAMIPVCNKPMIWY 49  Cryptosporidium...
EAR84576       5 YQVVILAGGq--GTELYPLCEr------------------------------------------fPKALLPVNNKPLIIY 40  Tetrahymena the...
EDK45184       3 FTAVILCGN---GKALFPFSEtrs--------------------------------------tglPKALIPVANKSILTY 41  Lodderomyces el...
CAG79840       5 FKVFILCGQ---GKNMAPLSSvra--------------------------------------sgvPKALLPMANVPVIDY 43  Yarrowia lipoly...
XP_829233     18 FDIVVFAGGk--APGLNPLCDn------------------------------------------ePKPMLCICNRPMIWY 53  Trypanosoma bru...
XP_001446558   5 YQAIILGGGqkaGSMLFPLCQd------------------------------------------ySKSLLPICNKPMILY 42  Paramecium tetr...
NP_065098     39 PLNLLEr--vGFEEVIVVTTrdvqkalcaefkm------------------------kmkpdivcipddADMGTADSLRY 92  human
EAU91280      55 ILSWLEq--aGIKDVLLICPaihrpalyhhihsdvs-----------------spslridlqtyeetqeSPAGTCELLRH 115 Coprinopsis cin...
P09032        80 VLDWCDq--aDFKEISVVAPvdeieliesgltsflslrkqqfeliykalsnsnhshhlqdpkkinfipsKANSTGESLQK 157 baker's yeast
AAW45625      57 VIDWVLa--aGLLDILIIVPnafhdqiadhiaeaynksthsr------vrinlrknsegerdedegdseEKDGTARILKK 128 Cryptococcus ne...
EAK89547      50 PLSNLIq--hRIRDICIFCEeefensirkyisetfsndtiikr---fefeetyqqnikiiglkedesllESSGTWSILSE 124 Cryptosporidium...
EAR84576      41 QLEKLEs--nGFTNVLILTSkntskieryikeyy----------------------qgqvkyelitipdEKKETFEAIRH 96  Tetrahymena the...
EDK45184      42 VLDWCFt--aSFSKILVVTSqesseqvqteidafqnekrlnl-----sldlkdydksttsnvsidlmgiTADHSGEAIYN 114 Lodderomyces el...
CAG79840      44 TLKWCEt--iPNPKVFVCCStadeaeisayvdsfka-----------------ehstsvvasnvticskTDAKSGDFILE 104 Yarrowia lipoly...
XP_829233     54 CLSPWIk--aGCSTFFVCVNedyaalqsylcrefp-------------------kvafvfvlvpltqnqTPTTTCDVVRG 112 Trypanosoma bru...
XP_001446558  43 QLDLLEtagfGPQDILILLTknhqavadlvq----------------------------rraeifyvseDSESGSALLEA 94  Paramecium tetr...
NP_065098     93 IYPkl----------ktDVLVLSCDLITDValhevv------dlfrayDASLAMLMrkgqdsiepvpg------------ 144 human
EAU91280     116 FSNri----------teDFVLVPCDFLAPPslplsqllntfrvestsdNNLLTTCWypvhvpdktvl------------- 172 Coprinopsis cin...
P09032       158 ELLpri---------ngDFVILPCDFVTDIppqvlvd-----qfrnrdDNNLAMTIyyknsldssidkkq---------- 213 baker's yeast
AAW45625     129 FRSfi----------ksDFVLLPCDISPPSylplktil---dkhrsspKAVMTSVFyepiesv----------------- 178 Cryptococcus ne...
EAK89547     125 YGKefl--------rdsDFFVLTCDVIGPLdllgla------nkhrltQAVCTILLtespdlskikgsgkqtsnsnn--- 187 Cryptosporidium...
EAR84576      97 VSNki----------nkDFILIACDSITDLglddvi------eqhiltGAYLTAVLkedkvdeennki------------ 148 Tetrahymena the...
EDK45184     115 ICTeskyk-----ietqNFIILSCDFITNLppqvliem---frnrpsnQLGITVAYrnqldiedkk-------------- 172 Lodderomyces el...
CAG79840     105 LTRge----------psDFIVVGCDFITDIpasslvd----tyrsrdsDSLLTAFYypntlenvdk-------------- 156 Yarrowia lipoly...
XP_829233    113 YLKhkeslksdrlskprDALLLSCDTFLPGvdvehfi-----hnfyasVASVSVLLfrpisssngnscgtqlgptargns 187 Trypanosoma bru...
XP_001446558  95 HEKik-----------kDFILLSCDSMIGAnildll------dfhyskKATITCLIkeedldkkqgr------------- 144 Paramecium tetr...
NP_065098    145 -----------------------------------------------------qkgkkkaveqrdFIGVDSTgk-rLLFM 170 human
EAU91280     173 ------------------------------------------------------sdewgpapsppAIVVDPAtg-sLLHI 197 Coprinopsis cin...
P09032       214 ---------------------------------------------------qqkqkqqqfftvysENEDSERqp-iLLDV 241 baker's yeast
AAW45625     179 ----------------------------------------------------------kdaeekiLVGLDKTsd-eLLLI 199 Cryptococcus ne...
EAK89547     188 --------------------------------------------qaqanpiggisvdlqkdknrsIFVIDEKde-vILSI 222 Cryptosporidium...
EAR84576     149 ------------------------------------------------------inpsssadnhdVFLIDETnn-kILYV 173 Tetrahymena the...
EDK45184     173 --------------------------------------------------------lkvfpkkytVYSDDSLmgscLLDQ 196 Lodderomyces el...
CAG79840     157 --------------------------------------------------------ksllkdvtvHSSLDSRtp-rLLDS 179 Yarrowia lipoly...
XP_829233    188 astpagsgkgnkgsqgsgacaakpythhftcvayeeksgdhvrndnnnngsalcpvasgvtensnKGSNCVShh-rLHFI 266 Trypanosoma bru...
XP_001446558 145 ------------------------------------------------------apiscnldesfDIMFIGSdq-sLLHI 169 Paramecium tetr...
NP_065098    171 ANEADLDEElvi---kgsILQKHpriRFHTGLVDAHLYCLKKYIV 212 human
EAU91280     198 DTPDDRDRNnedfqfsmgMISRFsrtKLTASFQDSHVYICQNKIL 242 Coprinopsis cinerea okayama7#130
P09032       242 YSQRDVTKTkylq-irshLLWNYpnlTVSTKLLNSFIYFCSFELC 285 baker's yeast
AAW45625     200 TPLEGMEEDlel---rmsLLNRHptlSLTTRILDAHVYVFRRTFL 241 Cryptococcus neoformans var. neoformans JEC21
EAK89547     223 KDFYSAKQEnevselsklQLFWHpnvSLRTDLVDLHVYLFKSSIF 267 Cryptosporidium parvum
EAR84576     174 NSFYEIKENglki--kksILASNpeaSIKTNLFDSHIYICKRQIL 216 Tetrahymena thermophila SB210
EDK45184     197 YTKEDTDMSkvll-irskMCFTYpnsVISTKLLDSGIFMGSREIF 240 Lodderomyces elongisporus NRRL YB-4239
CAG79840     180 YSRDYIENKktmp-irrsMLWHFpksLVSTQLLNASVYFCTADVC 223 Yarrowia lipolytica CLIB99
XP_829233    267 CPREDEPEPcis----fgFAARRpnlTFAADVVDVHAYLVRNWVL 307 Trypanosoma brucei TREU927
XP_001446558 170 TSQEDDDQVnlqv-srnvLLSCQs-vQIMTNLFDTHVYVCQYEVL 212 Paramecium tetraurelia
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