1FRW


Conserved Protein Domain Family
MobA
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cd02503: MobA 
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MobA catalyzes the formation of molybdopterin guanine dinucleotide.
The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.
Links
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Statistics
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PSSM-Id: 133000
Aligned: 120 rows
Threshold Bit Score: 103.424
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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GTP binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP binding site
Evidence:
  • Structure:1FRW; E.coli MobA with bound GTP, defined by 3.5 A distance
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ### #            #                              #                   #      
1FRW_A        7 ITGVVLAGGKARRMGgv----dKGLLELng-kpLWQHVADALMtq--lsHVVVNANrhqei--yqasgLKVIEDsla-dy 76  Escherichia coli
A7X5J2        1 MKAIILAGGHSVRFGk-----pKAFAEVng-etFYSRVIKTLEstnmfnEIIISTNaqlat---qfkyPNVVIDdenhnd 71  Staphylococcus a...
AAP11662      4 YAGIVLAGGMSSRFGe-----pKALAIWke-ttFVEHIVKVMGnt--lqDIVVISHtdikerveqfvqVPVIEDiphykg 75  Bacillus cereus ...
Q9K8I9        6 RIGVILAGGKSTRFGr-----pKAMVQYqe-ryFYEASLDALQhh--tdQVLIISHptltnqfrrnegIRVIEDdpryqg 77  Bacillus halodurans
YP_146616     5 IAGAVLAGGQSRRFGr-----pKAFALHeg-apFFTWSVAALDpi--adELYIVSHpslvdefrrqtdIPVLLDvercrg 76  Geobacillus kaus...
O31701        3 HVNVLLAGGASRRFGe-----pKAFVKWkg-rmLYECAKEALGe-----QTVIISRpefidrfqengeNEVYQDaepfqg 71  Bacillus subtilis
ZP_01724497   3 VAGVILAGGQSSRYGq-----pKMFETFag-lpLYKHSLNALQenq-lhPLVIATNaslhpr-fgpedVQWIIEqq--ph 72  Bacillus sp. B14905
YP_394528     5 TPCIIFAGGKSSRMGe-----dKALLPFgsydtLVEFQLYHLSki--fkTVYISCKeksk----fnfeAAFIEDiktlpl 73  Thiomicrospira d...
Q9ZL74        9 IPCVLLAGGKSSRFIinnipinKALMPLksypsLLEYQYTRLLkl--fkQVIISAKksy------elnAPYLLEkeg-gl 79  Helicobacter pyl...
AAP77616      6 IPCVILAGGKSSRLGe-----dKTQVAFgk-enLSQWVFTHLSki--ceKVYISTKdkkk----ftfdAPFLIErs--ri 71  Helicobacter hep...

Feature 1        ##  #                 # #                                                      
1FRW_A       77 PGPLAGMLSVMQqea-gewFLFCPCDTPYIPpdLAARLnhqr------kdaPVVWVHdgerDHPTIALVNraiePLLLEY 149 Escherichia coli
A7X5J2       72 KGPLAGIYTIMKqhpeeelFFVVSVDTPMITgkAVSTLyqflvshlienhlDVAAFKedgrFIPTIAFYSpnalGAITKA 151 Staphylococcus a...
AAP11662     76 NGPLAGIVSGMEyie-adwYAIMPCDAPNVSheWFTILleqt-----nneyDAVVPIingrKQPLLAAYHnrvkEKIYAL 149 Bacillus cereus ...
Q9K8I9       78 CGPLAGIFTAIEkes-aywYLTAPCDTPFLKkeIYDILfsyld---qepdkKAVIPVvngrKQPLIGLYHrsclAPIQSL 153 Bacillus halodurans
YP_146616    77 CGPLAGLYTVMEqsr-adwVFVLPCDMPYMRreVTERLasyi-----dpmfDAIVPLhgvrPEPLVALYHrrlrSVIAEL 150 Geobacillus kaus...
O31701       72 MGPLAGIYTAFKktd-gdlYTVLSCDTPLIQrrTMLELkrlm-----iagaDAVVPIsdgqVQPLIAIYHkrimPVLYDQ 145 Bacillus subtilis
ZP_01724497  73 QGPLFALYHILTafpevewFFVVASDMPYMNapFIEEMldni-----ndsyDAIVPKqnsrYQPLAALYRrtalPLAKQL 147 Bacillus sp. B14905
YP_394528    74 YAPTAGFISVYNhlk-sdnFFAISVDTPFITrsIIEKLlhvd-----knthDATIAKvnglIQPMCGVYHrslsEKFSQM 147 Thiomicrospira d...
Q9ZL74       80 FSPLFGIHNAFLtlq-tpyIFFIAIDTPLVSfeSIKILcgi-------qnfSVVYAKsptkEHYLISLWHqsilNALNYT 151 Helicobacter pyl...
AAP77616     72 YAPIIGMINAFEklk-tqeILFVSVDTPFVRgeTLRQLads--------naPITYAQsadkAHYLISKWHksmlDALIWA 142 Helicobacter hep...

Feature 1                                                 
1FRW_A      150 LqagerrVMVFMRLag-gHAVDFsdh---kdaFVNVNTPEEL 187 Escherichia coli
A7X5J2      152 LhsdnysFKNIYHEls-tDYLDVrdvdapsywYKNINYQHDL 192 Staphylococcus aureus subsp. aureus Mu3
AAP11662    150 LqeekrsMGQLLSQcn-vKYVSGedvqanadwFINVNTKEEY 190 Bacillus cereus ATCC 14579
Q9K8I9      154 Leqq-ryKVGFLFQlvdtLFVEDkafeqlhssFVNINRPEDL 194 Bacillus halodurans
YP_146616   151 LdagerrMISLLDRar-vRYVDAqqlaadetvWRNVNTEGEY 191 Geobacillus kaustophilus HTA426
O31701      146 LsekrlrISDLLGRis-vCYVQAeniganpaeFININTRDDF 186 Bacillus subtilis
ZP_01724497 148 MeqnkrsMKVLLDQlr-vSYVPFnen---cptFININAQHDW 185 Bacillus sp. B14905
YP_394528   148 LqnnshkLGYLLKNsn-tFYVEFede----ksFFNLNHPHEY 184 Thiomicrospira denitrificans ATCC 33889
Q9ZL74      152 LktqnyrLSDLIKNas-sTAIHFdke----eeFLNLNTLKDY 188 Helicobacter pylori J99
AAP77616    143 YksksyaLHRIIEShp-hQSVLAte-----keCFNINTMDDY 178 Helicobacter hepaticus ATCC 51449

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