2DPM,1BC5,1DCT,1DL5,1DUS,1EJ0,1F3L,1FBN,1FP1,1HNN,1I4W,1I9G,1IM8,1IXK,1JG2,1JQE,1JSX,1KHH,1L1E,1L3I,1M6Y,1MJF,1NE2,1NKV,1NV8,1NW3,1O9G,1P91,1RI5,1SQG,1T43,1UFK,1UWV,1VBF,1VID,1VL5,1VLM,1WS6,1XJ5,1XVA,1YUB,2ADM,2AS0,2DUL,2F8L,2FCA,2FHP,2FPO,2FRN,2H00,2O57,2OZV,2P35,2P7H,2PJD,2PKW,2PXX,2PY6,2QE6,2QFM,2QM3,2YQZ,2Z6Q,3BKW,3BZB,3CC8


Conserved Protein Domain Family
AdoMet_MTases

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cd02440: AdoMet_MTases 
Click on image for an interactive view with Cn3D
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Statistics
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PSSM-Id: 100107
View PSSM: cd02440
Aligned: 102 rows
Threshold Bit Score: 33.9427
Threshold Setting Gi: 28278354
Created: 29-May-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
S-adenosylmet..
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:S-adenosylmethionine binding site [chemical binding site]
Evidence:
  • Structure:2DPM, Streptococcus pneumoniae Dpn II DNA methylase with bound S-adenosylmethionine
    View structure with Cn3D
  • Citation:PMID 9862809

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #######                        ##                                           
2DPM_A     38 RYFEPFVGGGALFFDla----------pKDA-VINDFnaelincyqqikdnpqelieilkvhqeynskeyyldlrsadrd 106 Streptococcus pneu...
1FBN_A     77 KILYLGASAGTTPSHvadi------adkGIV-YAIEYaprixrell---------------------------------- 115 Methanocaldococcus...
1JQE_A     55 KILSIGGGAGEIDLQilskvqaqypgvcINN-EVVEPsaeqiakykel-------------------------------- 101 human
1NW3_A    158 LFVDLGSGVGQVVLQvaaa------tncKHH-YGVEKadipakyaetmdre----------------------------- 201 human
2O57_A     85 KGLDLGAGYGGAARFlvr-------kfgVSI-DCLNIapvqnkrnee--------------------------------- 123 Galdieria sulphuraria
2P7H_A     45 NLLELGSFKGDFTSRlq---------ehFNDiTCVEAseeaisha----------------------------------- 80  Pectobacterium atr...
2PY6_A    229 KXVDCGASIGESLAGligvt----kgkfERV-WXIEPdrinlqtlqnvl------------------------------- 272 Methylobacillus fl...
2QE6_A     80 QFLDLGSGLPTVQNThevaq---svnpdARV-VYVDIdpxvlthgr---------------------------------- 121 Thermobifida fusca YX
O28490     25 EVIEVGAGSGFVAERlkg--------kcKCI-LTTDIspfaam------------------------------------- 58  Archaeoglobus fulg...
NP_104553  97 KAAVLFCQTSAAADVlaa--------sgKVA-DIVRVeadta-------------------------------------- 129 Mesorhizobium loti...
Feature 1                                                                          ###        
2DPM_A    107 eridmmsevqraarilymlrvnfnglyrvnsknqfnvpygryknpkivdeelisaisvyinnnqLEIKVGDFekaiv--- 183 Streptococcus pneu...
1FBN_A    116 --------------------------------------------------------dacaerenIIPILGDAnkpqey-- 137 Methanocaldococcus...
1JQE_A    102 -----------------------------------------------------vakisnlenvkFAWHKETSseyqsrml 128 human
1NW3_A    202 --------------------------------------------------frkwmkwygkkhaeYTLERGDFlseewr-- 229 human
2O57_A    124 ------------------------------------------------------ynnqagladnITVKYGSFleipc--- 146 Galdieria sulphuraria
2P7H_A     81 ---------------------------------------------------------qgrlkdgITYIHSRFedaq---- 99  Pectobacterium atr...
2PY6_A    273 -----------------------------------------------------rrytdtnfasrITVHGCGAgentirvp 299 Methylobacillus fl...
2QE6_A    122 --------------------------------------------------------allakdpnTAVFTADVrdpeyiln 145 Thermobifida fusca YX
O28490     59 ----------------------------------------------------------elrrkgLDVVMTDIakgi---- 76  Archaeoglobus fulg...
NP_104553 130 -----------------------------------------------------------fltggGAGLIAPFetvpf--- 147 Mesorhizobium loti...
Feature 1                                               #                                     
2DPM_A    184 --------------------------------dvrtGDFVYFDppyiplsetsaftsythegfsfadqvRLRDAFKrls- 230 Streptococcus pneu...
1FBN_A    138 ------------------------------anivekVDVIYEDvaqp-------------------nqaEILIKNAkwfl 168 Methanocaldococcus...
1JQE_A    129 -----------------------------ekkelqkWDFIHMIqmlyy----------------vkdipATLKFFHsll- 162 human
1NW3_A    230 -------------------------------erianTSVIFVNnfafg----------------pevdhQLKERFAnmk- 261 human
2O57_A    147 --------------------------------ednsYDFIWSQdaflh----------------spdklKVFQECArvl- 177 Galdieria sulphuraria
2P7H_A    100 --------------------------------lprrYDNIVLThvleh----------------iddpvALLKRINddwl 131 Pectobacterium atr...
2PY6_A    300 fnhegghggfvkpadadhepadlidvrpiddiiddaPTFIKXDieg--------------------selSALKGARrais 359 Methylobacillus fl...
2QE6_A    146 hp------------------------dvrrxidfsrPAAIXLVgxlhyl--------------spdvvdRVVGAYRdal- 186 Thermobifida fusca YX
O28490     77 ---------------------------------rkkFSLVLFNppyvele-------------delrrgDWLDVAIdgg- 109 Archaeoglobus fulg...
NP_104553 148 --------------------------------epesLDLAVSLlsmqa----------------mndipGMLIQIRral- 178 Mesorhizobium loti...
Feature 1                                                                                     
2DPM_A    231 dtgAYVMLSnsssalveelykdfnihyv---------------------------------------------------- 258 Streptococcus pneu...
1FBN_A    169 kkgGYGXIAikarsidvtkdpkeifkeqkei------------------------------------------------- 199 Methanocaldococcus...
1JQE_A    163 gtnAKMLIIvvsgssgwdklwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwd 242 human
1NW3_A    262 -egGRIVSSkpfaplnfrinsrnlsdigti-------------------------------------------------- 290 human
2O57_A    178 kprGVXAITdpxkedgidkssiqpildriklhdxgslglyrslakecglvtlrtfsrpds--------------lvhhys 243 Galdieria sulphuraria
2P7H_A    132 aegGRLFLVcpnanavsrqiavkxgiishnsavteaefahghrctyaldtlerdasrag---------------lqvtyr 196 Pectobacterium atr...
2PY6_A    360 ehkPKLAISayhrstdlldltnyilsi----------------------------------------------------- 386 Methylobacillus fl...
2QE6_A    187 apgSYLFXTslvdtglpaqqklaritrenlgegwartpeeierqf----------------------------------- 231 Thermobifida fusca YX
O28490    110 -kkGVKVIKkf--------------------------------------------------------------------- 119 Archaeoglobus fulg...
NP_104553 179 rpdGLFLGAfa--------------------------------------------------------------------- 189 Mesorhizobium loti...
Feature 1                                                     
2DPM_A    259 -------------------------eatrtngaksssrgkiseiIVTN 281 Streptococcus pneumoniae
1FBN_A    200 ----------------------leaggfkivdevdiepfekdhvXFVG 225 Methanocaldococcus jannaschii
1JQE_A    243 fltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsFIVI 290 human
1NW3_A    291 -----------------------mrvvelsplkgsvswtgkpvsYYLH 315 human
2O57_A    244 kvkaelikrsseiasfcspefqanxkrglehwieggragkltwgGXLF 291 Galdieria sulphuraria
2P7H_A    197 sgiffkalanfqwdqilqtdilskeyldgcyqlgqqypdlcasiFLLC 244 Pectobacterium atrosepticum
2PY6_A    387 --------------------------rpdyqiglrhhtpdrwdtCLYF 408 Methylobacillus flagellatus KT
2QE6_A    232 ---------gdfelvepgvvytalwrpdepvdpdnlspgeqlgxAGIG 270 Thermobifida fusca YX
O28490    120 ------------------------------------------ldSLDE 125 Archaeoglobus fulgidus
NP_104553 190 ------------------------------------------gaGTLF 195 Mesorhizobium loti MAFF303099

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