3GKU,2PT7


Conserved Protein Domain Family
KH-II_Jag
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cd02414: KH-II_Jag 
type II K-homology (KH) RNA-binding domain found in protein Jag and similar proteins
Protein Jag, also called SpoIIIJ-associated protein, is associated with SpoIIIJ and is necessary for the third stage of sporulation. Members of this family are mainly from bacteria and contain only one canonical type II K-homology (KH) domain that has the signature motif GXXG (where X represents any amino acid).
Links
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Statistics
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PSSM-Id: 411785
Aligned: 53 rows
Threshold Bit Score: 60.2286
Created: 1-Feb-2005
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative RNAGXXG motif
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on the structure evidence that Mycobacterium tuberculosis NusA binds RNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #     #       #  #  ##  ##  #           
3GKU_A        65 KAIEFLEQVFDAXNx-aVDISVEYnet---------ekeXNVNLKGDd-----XGILIGKRGQTLDSLQYLVSLVVNKss 129 [Clostridium] s...
2PT7_G         6 EIKQELKDLFSHLPykiNKVEVSLyep----------gvLLIDIDGEd-----SALLIGEKGYRYKALSYLLFNWIHPty 70  Helicobacter py...
1653330        7 QAQNWLEELLTLMGf-pSTVTVAEdkent------lvmgPWLVIEEKnlsssqIERLLAENGLALDAIQYLLNASLRPav 79  Synechocystis s...
NP_218437     44 IAGDYLEELLDVLDf-dGDIDLDVeg-----------nrAVVSIDGSd----dLNKLVGRGGEVLDALQELTRLAVHQkt 107 Mycobacterium t...
BAB75115       8 RGQQWLQSLLELTGv-sAEIHGSLetaqshnedsqeidgYWLTIDETnlnpqqIQTLIGADGSVLDAIQYLVNSTLNInq 86  Nostoc sp. PCC ...
BAC90173       8 DARTWLQSALQLMGf-pDGVQVAEapdd-------pdgqRWLEIPEEalspaqKELLLNREGEVLDALQFLLNTTMHLqt 79  Gloeobacter vio...
Q0ATU4        65 EVRQVVEDLLNRMKidyQINQVECes-----------grVRVNIIGKd-----MGLLIGRKGETLNAVQYIIGLIINRqr 128 Syntrophomonas ...
WP_009166229  81 GFVVLLERVLKAAGl-dLEVNVQSdg------------sVNLSGPDS------RILLAGRQGEGLKALDYIVNLMARNdg 141 Pyramidobacter ...
WP_009959827   8 HARQILDTLLGYLGf-vVRIEEEEga-----------egPTLQIFTEe-----ADALVGHRGEVLDDIQYLVNRILQRrd 70  Verrucomicrobiu...
PWM54747     150 AAVSFVETLIKNLEi-eVEATVGTdee----------naSCITIDGKd-----ASVLIGHHGETLDALQYLANLAANRae 213 Ruminococcaceae...

Feature 1                  ####      
3GKU_A       130 s----dyiRVKLDTENYRER 145 [Clostridium] symbiosum ATCC 14940
2PT7_G        71 ------gySIRLEISTFLQN 84  Helicobacter pylori 26695
1653330       80 adgginftPITVELAEFRSR 99  Synechocystis sp. PCC 6803
NP_218437    108 g----vrsRLMLDIARWRRR 123 Mycobacterium tuberculosis H37Rv
BAB75115      87 pq--egqaSYTVELNGYRVK 104 Nostoc sp. PCC 7120
BAC90173      80 d----snqPYTVELAGHRLK 95  Gloeobacter violaceus PCC 7421
Q0ATU4       129 ------eeRIRVLLDVEDYR 142 Syntrophomonas wolfei subsp. wolfei str. Goettingen G311
WP_009166229 142 p-----vpHVRIDCEGFRRK 156 Pyramidobacter piscolens
WP_009959827  71 s----aapRVRVDVEYFRTM 86  Verrucomicrobium spinosum
PWM54747     214 gk--ddheRITVDVAGYRAR 231 Ruminococcaceae bacterium

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