1Q7S,1RLK,1RZW,1XTY,1WN2


Conserved Protein Domain Family
PTH2_family
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cd02407: PTH2_family 
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Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes.
Links
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Statistics
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PSSM-Id: 239091
Aligned: 56 rows
Threshold Bit Score: 97.997
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interfaceputative active
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #      ###  #  ##  #               #     #                   
1Q7S_A      3 YKMILVVRND-----LKMGKGKVAAQCSHAAVSAYKQIQRrnpe-----mlkQWEYCGQPKVVVKAPDeeTLIALLAHAK 72  Homo sapiens
NP_703767   6 IIQYILVNKEii--dKKWPLGSVIAQACHACVAVIAENMDdeivk---dylsPEHINNMHKVILKIDDtnEIKNLSSILD 80  Plasmodium falcipa...
NP_650561   4 IVQYIVVRSDlr-saLSWPLGAVIAQSCHATAAVIHLNSEdadt-----vayLNDLDNMHKVVLEAKDesALVKLSEKLK 77  fruit fly
AAF60890  100 YVMYVILRRDlq-tkLGWPLGAVCTQAAHAASASMWIFRNdpnt-----eayTSNLDSMHKVTLGVDSeeEIKKVADKLT 173 nematode
EAL19369   23 LVMQIIVRRDll-teHKWPVGPLLAQSAHAATAVLHRFRDhpdvkrylkgedGRGWETMRKVVLEVPDeaALKSLASKID 101 Cryptococcus neofo...
XP_420022  26 LVQYVVLRGDl---aRSWSLGAVVAQGCHAALAAAHAHWHhpdt-----rayLSAGGAMRTVVLEAPDeaALTALAQTLQ 97  chicken
EAA01514    3 LVQYVIVNGEi---aKSWPKGALIAQCCHAVAAVGHLYASdpdt-----veyFKDLDNMHKVVLEAPDagKLVSLGEVLQ 74  Anopheles gambiae ...
CAI21155   12 LVQYVIVRSDli-hsLSWPLGAVITQACHAATAAIHLHYSdpdt-----qqyLAELDSMHKVVLQAPDeaSLSTLSSTLE 85  zebrafish
CAI76366    8 LTQYVILREDlqtdgKPWPRGALIAQACHACISVNSLYNSdegvi---kytsFENLPNLRTVVLSVENesSLLDYHKVLT 84  Theileria annulata
XP_770256   7 ITQYIVLRND-----LPWGLGALAAQVAHASVAAIHAFREhpdv-----rvyLSDISNMRKVVLSADEq-QIIQLRDDLC 75  Giardia lamblia AT...

Feature 1                                                      #
1Q7S_A     73 m--lGLTVSLIqdagrtqiaPGSQTVLGIgpGPad---liDKVTGHLKLY 117 Homo sapiens
NP_703767  81 k--eSLKYKIWte-----ypENIFTAIALkpYYkn---tvRDYFKKYPLL 120 Plasmodium falciparum 3D7
NP_650561  78 e--nEIKHKLWie-----qpENIPTCIALkpYVkd---tvHKYVKHLKLL 117 fruit fly
AAF60890  174 a--rNVDHKVWi-------eDGFPVCIALkpYPke---evKNALKGLKLF 211 nematode
EAL19369  102 dmanPVGYHMWie-----qpENTPTALALvpNKrpkglkrAFDEVGCELF 146 Cryptococcus neoformans var. neoformans B-3501A
XP_420022  98 q--hSIDHEVWte-----qpENVPSCLALrpYPkd---qvHPHLKRFKLL 137 chicken
EAA01514   75 q--nDVKHKVWve-----qpENLPTCIALkpYPke---evQKYMKKFKLL 114 Anopheles gambiae str. PEST
CAI21155   86 e--kDIAHKLWme-----qpENIPTCLALkpYPke---tvQPYLKKFKLF 125 zebrafish
CAI76366   85 n--nLIKSHLFte-----kpENIVTCLATvpIDkr---kvGSLLKKLKTF 124 Theileria annulata
XP_770256  76 a--aKIDHFAWie-----qpENLLSAIGLrpCPke---lvRPYLKHLSLL 115 Giardia lamblia ATCC 50803

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