2JZX


Conserved Protein Domain Family
KH-I_PCBP_rpt2

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cd02396: KH-I_PCBP_rpt2 
Click on image for an interactive view with Cn3D
second type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
The PCBP family, also known as hnRNP E family, comprises four members, PCBP1-4, which are RNA-binding proteins that interact in a sequence-specific manner with single-stranded poly(C) sequences. They are mainly involved in various posttranscriptional regulations, including mRNA stabilization or translational activation/silencing. Besides, PCBPs may share iron chaperone activity. PCBPs contain three K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Statistics
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PSSM-Id: 411806
Aligned: 20 rows
Threshold Bit Score: 104.274
Created: 9-Feb-2005
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative DNAGXXG motif
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens PCBP2 (2AXY) binds telomeric DNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #    ## #####  #   #       ####    #   #                        
2JZX_A        88 PVTLRLVVPaSQCGSLIGKGGCKIKEIREstgAQVQVAGdmlpNSTERAITIAGiPQSIIECVKQICVVMLE 159 human
EDO42485     107 PVTLRLIVPgSQCGSIIGKGGAKIKEIREvsgASVVVAGeflpGSSERAVTLSGtPEALETCIDLLCGVMIE 178 starlet sea anemone
XP_011406106 182 VVSIRLIIQtSQCGSLIGKGGSRIKEIREvtgAIIQVSGeslpNSTERAVTISGsSQSISRCLDYICDVILE 253 Amphimedon queenslandica
NP_497351    152 PITMRVIVPaTQCGSLIGKGGSKIKDIREatgASIQVASemlpHSTERAVTLSGtADAINLCMTQVCQILLE 223 Caenorhabditis elegans
VZH90490     126 KIILRTLFPsSICGYILGKSGINVRHIRQetgCLLEFSPnklpNSTERVLFLSGdALAVCDAAERICKRIAT 197 Sparganum proliferum
EDV19529     127 TIKFDLLIPvPHCRSIIGKGGGTVKEIREstgAQVSIASnvlpNSSDRVMTITGsSSAISKCIQRLSQLLSE 198 Trichoplax adhaerens
VDN97427     106 KFVFRMLLPaSLCGHLIGQQGECIHKLRQitgSLVKITRqklpNSTERILFIYGtVTSITACLEMICALLGE 177 Rodentolepis nana
GAA49803      39 PITLRLLVPtIHCGSLIGKGGKRIKFLRQstgAAIQVASeslpNSSDRTITITGsARAVALCVHHVCLKTLR 110 Clonorchis sinensis
NP_001035073 102 PVTLRLVFPaSQCGSLIGKGGSKIKEIREstgAQVQVAGdllpDSTERAVTISGtPHAITQCVKHICTVMLE 173 zebrafish
TBU26965     321 SIALRVLVPhTLLYSVTGGDSVNIPVIQEssgAQLSIRKetlpQSLERLLEVNGsPDTIGRATERICECLLR 392 Dichomitus squalens

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