4WAL,4WAN


Conserved Protein Domain Family
KH-I_BBP

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cd02395: KH-I_BBP 
type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) and similar proteins
Yeast BBP, also called mud synthetic-lethal 5 protein, or splicing factor 1, or zinc finger protein BBP, is a mammalian splicing factor SF1 ortholog. It is involved in protein-protein interactions that bridge the 3' and 5' splice-site ends of the intron during the early steps of yeast pre-mRNA splicing. BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC.
Statistics
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PSSM-Id: 411805
Aligned: 25 rows
Threshold Bit Score: 128.873
Created: 31-Jan-2005
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA bindingGXXG motif
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         # ### #####  ##        #####   # #  #                           
4WAL_A          5 KFQDKYYIPVDqyPDVNFVGLLLGPRGRTLRKLQEDSNCKIAIRGRGSVKEGKnasdl-ppgaXNFEDPLHCLIXADSeD 83   Saccharomyces...
EEY67359       50 KKRKKVYIPVDkyPDINFMGLLIGPRGSNQKRMEDESGARILIRGKGSSKDPTg--------dPDENEELHVLITADTdE 121  Phytophthora ...
CAK66033      122 KVRRKIKIPPD--LSFNYIGLIIGPKGVSQKKLEEETGAKILVRGRGSQKPEQpp-------qPDDDEDLHVLVVAETpQ 192  Paramecium te...
PSC74708      178 RKWKKIFIPFKqyPGYNFIGLIIGPRGNTQKRMQAETNTKIAIRGRGSVKEGAsrdp---kydYGEDEELHVLITGDKqE 254  Micractinium ...
XP_004339347  119 KKTRKIRVPIDkyPDYNFIGLIIGPRGDTHKQLEKKSGAKISIRGKGSQKEGQagk----kftGDEEEDLHVLITGDTdK 194  Acanthamoeba ...
EAL46666      137 KRTKKIYFPKDr-PDTNFIGLIIGPRGDNQKRLEKDSGAKISIRGKDPKKLGKlsg-----ygDKDNEDSHVFITADTqE 210  Entamoeba his...
PNW75945      196 KKTRKLFIPQRdhPSYNFIGLIIGPRGNTQKRMEKETNTKIAIRGKGSVKEGRtrrdlsgrpePGEDEELHVLISGDTdD 275  Chlamydomonas...
CAG25048      156 KKIRKIEIPIDkyPEYNFMGLIIGPRGCNHKRLEAESGAQISIRGKGTLKEGKktdh---qteIEAAMPKHVHIAADTeE 232  Plasmodium fa...
XP_022840011  199 KRTAKLLIPVDeyPGYNFFGLIIGPRGSTQKQMQRETNTRIVIRGRGSAKGGTgaae---rnnEYDNEPLHVLIEGDVqS 275  Ostreococcus ...
XP_002364676  149 KKIRRIEIPLDkyPDYNFMGIIIGPRGCNHKRLEAESGTTISVRGRGTQKEGKrdh----qteEEASMPMHVHICGDTeE 224  Toxoplasma go...
Feature 1                       
4WAL_A         84 KXQKGIKVCQNIXI 97   Saccharomyces cerevisiae S288C
EEY67359      122 AVAKAQSAVEEILF 135  Phytophthora infestans T30-4
CAK66033      193 QAANACDRIERILL 206  Paramecium tetraurelia
PSC74708      255 DVDAAAAMIQRLLQ 268  Micractinium conductrix
XP_004339347  195 QLDIAADMVEKLLV 208  Acanthamoeba castellanii str. Neff
EAL46666      211 ALDLACEEITKIIS 224  Entamoeba histolytica HM-1:IMSS
PNW75945      276 DVDRAAALIEKLLQ 289  Chlamydomonas reinhardtii
CAG25048      233 CVEKAVSLITPLLD 246  Plasmodium falciparum 3D7
XP_022840011  276 DVDKAKAMIQKLLI 289  Ostreococcus tauri
XP_002364676  225 AVEKALALIEPLLD 238  Toxoplasma gondii ME49

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