Conserved Protein Domain Family
ZZ_Mind_bomb
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cd02339: ZZ_Mind_bomb 
Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has been shown to regulate signaling by the Notch ligand Delta in Drosophila melanogaster.
Links
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Statistics
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PSSM-Id: 239079
Aligned: 11 rows
Threshold Bit Score: 90.2103
Created: 29-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Zinc-binding sites [ion binding site]
Evidence:
  • Comment:6 conserved cysteines and 2 conserved histidines coordinate 2 zinc ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #           #  #     #  #     #   #     
CAG01730       98 IICDSCKkHGIMGMRWKCKVCFDYDLCTQCYMNNKHDLSHAFERY 142  Tetraodon nigroviridis
AAN75493       83 TMCDTCRqQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRI 127  human
EAA14796       84 IICDGCNkAGIAGIRFRCAECASYDLCATCYGNDLHDLEHPFIRF 128  Anopheles gambiae str. PEST
NP_609933      85 VVCDGCSkAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRY 129  fruit fly
NP_001006301   89 IICDCCKkHGIRGMRWKCKMCFDYDLCTQCYMNNKHDLSHAFERY 133  chicken
BAC05413       89 IICDCCKkHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRY 133  human
NP_775393      83 TMCDTCRqQPIIGIRWKCAECTNYDLCTTCYHGDKHHLRHRFYRI 127  zebrafish
XP_419157      83 TMCDTCRqQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRI 127  chicken
AAH73370       83 TMCDTCRqQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRI 127  African clawed frog
NP_648826     177 TMCDTCRqQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRI 221  fruit fly
AAS38707      285 ALCDMCQ-NQIIGYRYKCKVCPNYDLCQTCKDTNKHNPEHEFVAH 328  Dictyostelium discoideum

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