1T3T,1VK3


Conserved Protein Domain Family
PurL_repeat2

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cd02204: PurL_repeat2 
Click on image for an interactive view with Cn3D
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Statistics
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PSSM-Id: 100035
View PSSM: cd02204
Aligned: 149 rows
Threshold Bit Score: 148.067
Threshold Setting Gi: 49259562
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingdimerization
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1T3T; Salmonella FGAR-AT with bound ATP, 3.5 A
    View structure with Cn3D
  • Comment:The N- and C-terminal repeats of PurL bind ATP/ADP

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                    #   #                                
1T3T_A        687 DCAVTTasl----dsyYGEAMSIGERAPVALLDFAASARLAVGEALTNIAATQIGdikrIKLSANWMAAAGhp-geDAGL 761  Salmonella ty...
ZP_02035125   678 QAMAALlpvgpghetdTCSVMAWGFDPDRMARDPFGGAQASVVESLARLVASGCDyrkaYFSFQEYFEKLRtdperWGKP 757  Bacteroides c...
YP_001692667 1088 QAMVAKiptmd-gimkTVSMMSYGFDADLSVQSQYLGGYYAVVESISKLIALGSDknliRLTFQEYYEKMLdk-kiWSKP 1165 Finegoldia ma...
NP_603887     687 DVSIMKfpvln-kntnTASAITWGFNPYISEWSTYHGAIYAVVESLAKLVAAGVDyktaRLSFQEYFEKLGkdsykWSKP 765  Fusobacterium...
ZP_02861935   680 DGMVSKvplek-gdttTATVMTNGFDPELLSENPYIGAVYAVLSSVSKAVSMGADykklRLSFQEYFERLRkdptrWAKP 758  Anaerofustis ...
ZP_02424903   675 QVSVQKlptd--gytdTASIMAFGYNPFLASWSPYHGAAYAVVDAAAKVVAAGARydkmRYSYQEYFERMTksprtWGKP 752  Alistipes put...
NP_720513     681 EASVQKlpvqn-gvttTASVMAQGFNPYIAEWSPYHGAAYAVIEATARLVATGADwsraRFSYQEYFERMDkqadrFGQP 759  Streptococcus...
NP_940446     669 LASVQTfpvp--ggshTASVMTYGFSPELADVSPYLMGSYSVVEALSRLVATGANargaWLSVQEYFQRLDqkpelWGEV 746  Corynebacteri...
ZP_02077068   671 EGSVQKlpvl--gftnTCSIMTHGYHPELSQYSPYLGASYSVVEALARVAALGGNyatcRLTNQEYFERLHndpekWGKP 748  Eubacterium d...
ZP_02094769   678 QAGIQAlptih-stsdTATILSYGFIPKISHYSPFLSAIYAVLESVAKVYAVGGDksnlYFSFQEYFEKLGkdskkWGKV 756  Peptostreptoc...
Feature 1                             ###                                                         
1T3T_A        762 YDAVKAVGeELCPQLGLtIPVGKDSMSMKtrwqegneqremtSPLSLVISAFARVEDvrhtltpqlsteDNALLLIDlgk 841  Salmonella ty...
ZP_02035125   758 FQALLGAL-RAQLELGVaAIGGKDSMSGSfld--------ldVPPTLVSFAIAPAKAgevisp-efkagGHPVYLFQsvs 827  Bacteroides c...
YP_001692667 1166 LKALLGAF-TVSKYFKAmPIGGKDSMSGNfed--------itVPPTMISFAVTHEDVdniit--ndlkgKGKIGLVRtpy 1234 Finegoldia ma...
NP_603887     766 FLALLGAM-KVQKDFDVaAIGGKDSMSGTfnd--------isVPPTLISFAVSTVNVtdvist-efkkaKNKIYLVEnki 835  Fusobacterium...
ZP_02861935   759 FIALLGAL-KVQLELNTpAIGGKDSMSGSfed--------idVPPTLISFAVGVVDAnkvvss-dfknaGNNVYVIKidk 828  Anaerofustis ...
ZP_02424903   753 LGALLGAL-KMQVELGLpSIGGKDSMSGTfeq--------inVPPMLMAFGITTVDAgrvist-dfkkaGHSIYLVRhtp 822  Alistipes put...
NP_720513     760 VAALLGSI-EAQIQLGLpSIGGKDSMSGTfee--------ltVPPTLVAFGVTTVDSrqvlspefktvgENIYYIPGqai 830  Streptococcus...
NP_940446     747 TQALLGLL-EAQDAFEVaAIGGKDSMSGTygd-------dlhVPATLVTFAVATMDArrtlsaaipsgeFDVYHLAHtpl 818  Corynebacteri...
ZP_02077068   749 MQALLGLI-EAELAFETpAIGGKDSMSGTfnd--------itVPPTLITFAVTTEKTqniiss-efkkaGSRIYLLKhtp 818  Eubacterium d...
ZP_02094769   757 TQSLLGTI-YAQNEIGCpSIGGKDSMSGTfnd--------lnVIETLISFACTPVKIknvisp-elktiGNYIYYVPivk 826  Peptostreptoc...
Feature 1                                                                                         
1T3T_A        842 ghnalgatalaqvyrqlgdkpadvrdvAQLKGFYDAMQALVaarkllAWHDRSdggllvTLAEMAFaghCGVQVDIaalg 921  Salmonella ty...
ZP_02035125   828 y-----------------------ndyGSLKKTWENFHELCqagkvcSAWAVGsgglaeGIMKMSFgnrVGFTAEPsaes 884  Bacteroides c...
YP_001692667 1235 eed-------------------gtlnlEKLEENFDFITEQIrnkniiSAIALDkkgllaNIFEQSVg-nTGFNIKFdnl- 1293 Finegoldia ma...
NP_603887     836 nek------------------dflfdsQELKENFHFILKNIkdkkivSAMVVKigglaeVLSKMSFgnrLGFEINNknvd 897  Fusobacterium...
ZP_02861935   829 ten-------------------ntpnyDSVRSAFDLVHKLIeegkvkSSKSITvggvaeAVSKMCFgnkIGFEFLDsdyd 889  Anaerofustis ...
ZP_02424903   823 len-------------------hmpdtGALKRNFDFVSSAIesgkivSGYAVGfggvaeALAKMSFgngIGADVEVdeat 883  Alistipes put...
NP_720513     831 se---------------------dinfDYIKANFAQFEAIQakhkvtAASAIKyggvleSLALMSFgnhIGASVELteld 889  Streptococcus...
NP_940446     819 et--------------------geanyEQLRANFDAFHELAatgtlsAASPIIpgglgaTIVNMLLgneLGFQGTAtt-- 876  Corynebacteri...
ZP_02077068   819 ken-------------------mtpnyEQLKENFAKMYQLAcehkilSASTVKfggiseALCKATFgnkLGVDVHTsepl 879  Eubacterium d...
ZP_02094769   827 nsk-------------------gypeiKETLKSYEQINELIksgkilSAYVQEegsvvsSLVKMAVgngLGFTVNKeni- 886  Peptostreptoc...
Feature 1                                                      
1T3T_A        922 ddhlaalfneELGGVIQVRAedrdaveallaqygladcVHYLGQA 966  Salmonella typhimurium
ZP_02035125   885 s----lfytgMCGAILAECDgpv-------------pgGMLVGHT 912  Bacteroides capillosus ATCC 29799
YP_001692667 1294 -------ynpMYGSFVVEYIddd-------------enIEHIGEF 1318 Finegoldia magna ATCC 29328
NP_603887     898 ------lfslKPASILIETTeels-----------yknAIYLGEV 925  Fusobacterium nucleatum subsp. nucleatum ATCC 25586
ZP_02861935   890 ------iyakNYGDIIIETSedln-----------dknAVLLGKT 917  Anaerofustis stercorihominis DSM 17244
ZP_02424903   884 ------lfdnSYGSIVVESTepld-----------fpaAELLGHT 911  Alistipes putredinis DSM 17216
NP_720513     890 s-----sltaQLGGFVFTSDeai-------------adAVKIGQT 916  Streptococcus mutans UA159
NP_940446     877 --------naALGGLVFAVPagtav---------eladAQLIGHT 904  Corynebacterium diphtheriae NCTC 13129
ZP_02077068   880 -------ydlSLGSILVESEteiq-----------daaFVEIGRV 906  Eubacterium dolichum DSM 3991
ZP_02094769   887 -------lnfDPASIVVESNce--------------lpFEKIGMV 910  Peptostreptococcus micros ATCC 33270

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