1VK3,1T3T


Conserved Protein Domain Family
PurL_repeat1

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cd02203: PurL_repeat1 
Click on image for an interactive view with Cn3D
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Statistics
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PSSM-Id: 100034
View PSSM: cd02203
Aligned: 120 rows
Threshold Bit Score: 336.366
Threshold Setting Gi: 32490886
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingdimerization
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1T3T; Salmonella FGAR-AT with bound ATP, 3.5 A
    View structure with Cn3D
  • Comment:The N- and C-terminal repeats of PurL bind ATP/ADP

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
1VK3_A         33 ELQAFSVXWSEHCGYSht------------kKYIRRLpktgfegna---------------------------------- 66   Thermotoga ma...
1T3T_A        213 ELYMFAQANSEHCRHKifnadwiidgkpqpkSLFKMIkntfettpdyvlsaykdnaavme-------------------- 272  Salmonella ty...
NP_940446     211 ELAALDTYWSDHCRHTtf------------nTELTEItnsssrygaqldralkrydelreangrahkprtlmdlgt---- 274  Corynebacteri...
ZP_02035125   218 ELRVVDTYWSDHCRHTtf------------gTHIDKAeilddevaqayqeylaareevygpekaavrpqtlmdmat---- 281  Bacteroides c...
NP_561596     213 EIKVIDTYWSDHCRHTtf------------eTIIKDVyieegkysepikkayedyknsrayvygenlnnkevklmdl-at 279  Clostridium p...
YP_001692667  621 EIKILDTYWSDHCRHTtfntfld--iefnakTKLDEAihnsfeeylkvreelkiekpinlmsfgtilskymr-------- 690  Finegoldia ma...
NP_603887     215 EIKVLDTYWSDHCRHTtf------------eTKINKVtfpdsefgkqmekefndylklkedvskkrdvslmdmativaky 282  Fusobacterium...
ZP_02424903   208 ELRILDTYWSDHCRHTtf------------tTELENItveesfvkdeiegtlalylkirrelgregksiclmdlat---- 271  Alistipes put...
NP_606356     230 ELKVLDTYWSDHCRHTtf------------eTELKNIdfsaskfqkqlqttydkyiamrdelgrsekpqtlmdmat---- 293  Streptococcus...
ZP_02077068   209 ELKVLDTYWSDHCRHTtf------------eTVLQNIkfdagslqdsmqkayelylklreevhggkkvmtlmdmat---- 272  Eubacterium d...
Feature 1                                                                          #   #          
1VK3_A         67 ------------------------------gvvnlddyYSVAFKIESHNHPSAIEPYNGAATGVGGIIRDVLAX--GARP 114  Thermotoga ma...
1T3T_A        273 ----------------gsavgryfadhntgrydfhqepAHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATgrGAKP 336  Salmonella ty...
NP_940446     275 imvrelrrngtmtdqevseeinacsvyvdvdtpegdkpWLLMFKNETHNHPTEIEPFGGASTCLGGAIRDPLSG--RSWV 352  Corynebacteri...
ZP_02035125   282 lgakvlkkrgvltgldeseeinacsvhvtatvdgeeqdWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSG--RAYV 359  Bacteroides c...
NP_561596     280 iamkelrkrgklddldvseeinacsinieietdkgteeYLLMFKNETHNHPTEIEPFGGAATCLGGAIRDPLSG--RSYV 357  Clostridium p...
YP_001692667  691 ---sknefddleisseinacsvkikvrvevngvdetrdYLLMFKNETHNHPTEIEPFGGASTCLGGAIRDPLSG--RAFV 765  Finegoldia ma...
NP_603887     283 lkkegkldnlevseennacsvyvdvevedfegkkaiekWLLMFKNETHNHPTEIEPFGGASTCLGGAIRDPLSG--RAYV 360  Fusobacterium...
ZP_02424903   272 igarylrskgllddlevseennacsvfvdvdvddrtekWLLQFKNETHNHPTEIEPFGGASTCLGGAIRDPLSG--RSYV 349  Alistipes put...
NP_606356     294 ifgryerangrlddmevsdeinacsveievdvdgvkepWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSG--RSYV 371  Streptococcus...
ZP_02077068   273 iagkylrkqgklddmeisdeinacsieisvdvdgkeepWLLMFKNETHNHPTEIEPFGGASTCIGGAIRDPLSG--RSYV 350  Eubacterium d...
Feature 1                                                                  ###                    
1VK3_A        115 TAIFDSLHXs-------------------------rIIDGIIEGIADYGNSIGVPTVGGELRIssly-----------ah 158  Thermotoga ma...
1T3T_A        337 KAGLVGFSVsnlripgfeqpweedfgkperivtaldIMTEGPLGGAAFNNEFGRPALTGYFRTyeekvnshngeelrgyh 416  Salmonella ty...
NP_940446     353 YQAMRISGAgdintprtet--------idgklpqadISARATHGYSSYGNQIGLATTSVRELIhpgy-----------va 413  Corynebacteri...
ZP_02035125   360 YQAMRVTGCgdprtpldqt--------lsgklsqrkIAQTAAAGYSSYGNQIGLATGQVSEIYhpgy-----------va 420  Bacteroides c...
NP_561596     358 YQAMRVTGSadptveicet--------lkgklpqrkITLGAAHGYSSYGNQIGLATGQVSEIYhpny-----------aa 418  Clostridium p...
YP_001692667  766 YQAMRITGAgnpltsledt--------mdgklpqikITQEAAKGYSSYGNQIGLATGFVDEIYhdgy-----------va 826  Finegoldia ma...
NP_603887     361 YQAIRVTGSgnpletveet--------lkgklfqkkITTGAASGYASYGNQIGIATSLVSEIYhdgy-----------ka 421  Fusobacterium...
ZP_02424903   350 YQAMRVTGAgniyqpvset--------lpgklpqrvISLKAAAGYSSYGNQIGLATTHVREVYhpdy-----------va 410  Alistipes put...
NP_606356     372 YQAMRISGAgdittpiaet--------ragklpqqvISKTAAHGYSSYGNQIGLATTYVREYFhpgf-----------va 432  Streptococcus...
ZP_02077068   351 YQAMRISGAgditkdiadt--------lpnklpqsrISKGAAAGYSSYGNQIGLATTYVKEIFhdgy-----------va 411  Eubacterium d...
Feature 1                                                                                         
1VK3_A        159 nPLVNVLAAGVVRNdxlvdskasrpGQVIVIFGGATGRDGIHGAsfasedlt--gdkatklsIQVGDPFAEKXLIEAFLE 236  Thermotoga ma...
1T3T_A        417 kPIMLAGGIGNIRAdhvqk-geivvGAKLIVLGGPAMNIGLGGGaassmasgqsdadldfasVQRDNPEMERRCQEVIDR 495  Salmonella ty...
NP_940446     414 kRMELGAVVAAAPQenvkr-lepqpGDVVIILGGRTGRDGVGGAtgsskahdeeslarsgaeVQKGNPVNERKIQRLFRR 492  Corynebacteri...
ZP_02035125   421 kHLELGAVVAAAPAehvvr-ecpapGDVVILLGGRTGRDGIGGAtgsskshnlesldtmaseVQKGNAPEERKIQRLFRR 499  Bacteroides c...
NP_561596     419 kRMEVGAVIAATPKenvir-lepskGDIVILLGGRTGRDGIGGAtgsskehteesinqcgaeVQKGNAPTERKIQRLFRN 497  Clostridium p...
YP_001692667  827 kRLECGAVMAAAPIenvkr-iepekGDIVILLGGRTGRDGIGGAtgsskshkvtsiktesaqVQKGNAPEERKIQRLFRI 905  Finegoldia ma...
NP_603887     422 kRMEVGAVVAAAPVenvvr-kspvpTDSIIIIGGKTGRDGCGGAtgsskehndkslllcgaeVQKGNAPEERKIQRLFRN 500  Fusobacterium...
ZP_02424903   411 kRLEVGAVVGAVKAenvrr-espvpGDVVLLLGGRTGRDGVGGAtgsskehtdkslemcgseVQKGNAPEERKLERLFRR 489  Alistipes put...
NP_606356     433 kRMELGAVVGAAPKenvvr-ekpeaGDVVILLGGKTGRDGVGGAtgsskvqtvesvetagaeVQKGNAIEERKIQRLFRD 511  Streptococcus...
ZP_02077068   412 kRMEVGAVVGAAPKenvvr-kspetGDIVVLIGGATGRDGVGGAtgsskehndtsltkcsseVQKGNAPIERKLQRLFRN 490  Eubacterium d...
Feature 1                                                                                         
1VK3_A        237 Xve---egLVEGAQDLGAGGVLSATSELVakgnLGAIVHLDrvplrepdxepwEILISESQERXAVVTSpqkASRILEIA 313  Thermotoga ma...
1T3T_A        496 CwqlgdanPILFIHDVGAGGLSNAMPELVsdggRGGKFELRdilsdepgmsplEIWCNESQERYVLAVAadqLPLFDELC 575  Salmonella ty...
NP_940446     493 Pei---aqMIVRCNDFGAGGVSVAVGELT----DSIDIHLDrvplkyaglnarEIAISESQERMAVVVRpedAAAFIEAA 565  Corynebacteri...
ZP_02035125   500 Gev---trLIKRCNDFGAGGVSVAIGELA----DGLSISLDavrkkydgldgtELAISESQERMAVVVApqdAAAFIAAA 572  Bacteroides c...
NP_561596     498 Kev---aqMIKRCNDFGAGGVSVAIGELC----RGIDIDLNkvpkkyegldgtELAISESQERMAVVISsenADRFIKLS 570  Clostridium p...
YP_001692667  906 Pel---asLIKKCNDFGAGGVSVAIGELH----DGVDIYLDrvplkykglkpfEIAISESQERMACVIAkkdLEEFVKYA 978  Finegoldia ma...
NP_603887     501 Pna---tkLIKKCNDFGAGGVSVAIGELA----DGVEVNLDlvpvkyeglngtELAISESQERMAVIVSkedTEKFLKYV 573  Fusobacterium...
ZP_02424903   490 Pev---trLIKKSNDFGAGGVSVAIGELT----DGLDIYLDrvptkysglnatELAISESQERMAVVIEasaEEEFKRYC 562  Alistipes put...
NP_606356     512 Gev---trLIKKSNDFGAGGVCVAIGELA----DGLEIDLDkvplkyqglngtEIAISESQERMSVVVRpsdVDAFIAAC 584  Streptococcus...
ZP_02077068   491 Pka---trLIKKANDFGAGGVSVAVGEIA----DGLLIDLDkvpvkysglsgtELAISESQERMAVLIEkdaFEEFRQLA 563  Eubacterium d...
Feature 1                                          
1VK3_A        314 RkhllFGDVVAEVieepvyRVXYrn--dlVXEV 344  Thermotoga maritima
1T3T_A        576 KreraPYAVIGDAteeqhlSLHDnhfdnqPIDL 608  Salmonella typhimurium
NP_940446     566 AteniEAVELAIVtdsgrlRMFLge--dvVLDL 596  Corynebacterium diphtheriae NCTC 13129
ZP_02035125   573 EsenlEAYQVATVtedprmVMTWng--qtVANL 603  Bacteroides capillosus ATCC 29799
NP_561596     571 EeenlEATIVAEVtdtdrlRMNWkd--ktIVDI 601  Clostridium perfringens str. 13
YP_001692667  979 DaeniETTVVADItdtnrmRMFYde--dlIADI 1009 Finegoldia magna ATCC 29328
NP_603887     574 DeenlLGTVVGYVtdknrlTLNWkg--kaIVDI 604  Fusobacterium nucleatum subsp. nucleatum ATCC 25586
ZP_02424903   563 AeeniEVTHVADVtdsrrmRMYNkg--klVVDL 593  Alistipes putredinis DSM 17216
NP_606356     585 NkeniDAVVVATVtekpnlVMTWng--etIVDL 615  Streptococcus pyogenes MGAS8232
ZP_02077068   564 YeenlDSCIVAEVteekrlVMTFhg--eeIVNI 594  Eubacterium dolichum DSM 3991

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