2Z1T,2Z1E,2I6R,2Z1U


Conserved Protein Domain Family
HypE

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cd02197: HypE 
Click on image for an interactive view with Cn3D
HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the ATP-binding domains of the AIR synthases, selenophosphate synthetase (SelD), and FGAM synthase and is thought to bind ATP.
Statistics
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PSSM-Id: 100033
View PSSM: cd02197
Aligned: 92 rows
Threshold Bit Score: 350.596
Threshold Setting Gi: 148259348
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingdimerization
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                            #                        #  
2Z1T_A        14 SGGRASHRLISDLFLRHFdnpilgtln----------daarldltGPLAMSTDSYTVDPIFFPGGDIGTLAVHGTVNDVS 83  Desulfovibrio v...
2Z1U_A        14 SGGRASHRLISDLFLRHFdnpilgtln----------daarldltGPLAMSTDSYTVDPIFFPGGDIGTLAVHGTVNDVS 83  Desulfovibrio v...
YP_921011     17 QGGVETLRLLEELFFRRVkehlkrveggvgidfpddgaliplpggGFLVVTADSYTVNPPFFPGGNIGSLAVHGSINDVV 96  Thermofilum pen...
YP_001153524  11 AGSVETSQILESLIFSKIeerlkkvegglgidfpddaaaipmgdgRFLVVTVDSYTVNPPFFPGGDIGVLAASGSINDVL 90  Pyrobaculum ars...
YP_001013220  22 SGGRETGEIVEKLIRPMVpeelwrveggwgldvlddsaliplpdgRYLAFTVDSYTVKPLFFPGGDLGKLAASGVINDLL 101 Hyperthermus bu...
ACB07870      11 SGGKETSLILKSLILSALseeelslrggvglkelddgaaiplpdgTYLVVSIDAYTVNPPFFPGGDLGKLAACGTINDIL 90  Candidatus Kora...
YP_001040034  13 SGGFETLEIIEKLIVHRVpenlrkvldgvgl-dvlddgssmrignTHIVISTDNFTVKPLFFPGGDIGHLAVSGVLNDLV 91  Staphylothermus...
YP_001056452  10 AGGVETSEILQRLIFSKVppglkkveggvgi-dfpddaaaipvgdGYIVVTTDSYTVSPPYFSGGNIGTLAASGTINDVV 88  Pyrobaculum cal...
YP_001435080   9 GGGRETEEFIKNFILPLFkirslgsvgldd---ledgaavpigdnKYLVVSVDSYTVSPPFFPGGDIGKLAATGSLNDVA 85  Ignicoccus hosp...
ZP_02172566   15 SGGRAMRQLIEDVFLSLAspvdgiglsal------ddgaairvgdRWLVITTDSHVVHPIFFPGGDIGRISVSGTVNDLA 88  Anaeromyxobacte...
Feature 1                                                                                        
2Z1T_A        84 MLGAR-PRYLSCGFILEEGLDMDILERVVASMGKAAREAGVFIVTGDTKVVPRGacdkMFINTTGIGEILvdpapsgdra 162 Desulfovibrio v...
2Z1U_A        84 MLGAR-PRYLSCGFILEEGLDMDILERVVASMGKAAREAGVFIVTGDTKVVPRGacdkMFINTTGIGEILvdpapsgdra 162 Desulfovibrio v...
YP_921011     97 MMGGR-PVAMLDTIVVEEGFPMGDLEAIVNSMLEALEKEGVPLIGGDFKVMPKGqldrITVTTVGLGVARspivd---kp 172 Thermofilum pen...
YP_001153524  91 MLGGK-PIALMDAIIVEEGFPLEDLRRIVDSMLRVLREEGVALIGGDFKVMPKGqidkIAIATVGIGIADrlivd---rp 166 Pyrobaculum ars...
YP_001013220 102 MAGAK-PLAAVDAVVVEEGFPVEDLARILESLASTLAANKVALIGGDFKVVPKGdldgVIITMAGVGVAEkpivd--tri 178 Hyperthermus bu...
ACB07870      91 MMGGE-PKAILDSIVVEEGSPISDVRRIVNSFIGVLREEGVKLIGGDFKVMPRGqldrYVVTTAGIGIAKrpivd--ssi 167 Candidatus Kora...
YP_001040034  92 MMGAR-PIAFMDGIIVEEGFPRDDLDRILESMIKLLKENNVALIGGDFKVMPKKsldgLIISGTGIGLAEkpiid---ki 167 Staphylothermus...
YP_001056452  89 MMGAR-PIAALDAIIVEEGFPVKTLEDIVESMISIFTKEGVALIGGDFKTMPKGqidgVVITTVGIGISKgpviv--dkp 165 Pyrobaculum cal...
YP_001435080  86 VMGAE-PKALMDAIIVEEGFKLSDLKTILKSMSEVTNSLNVALLGGDTKVMPKGsvdkIVISTVGIGIAEgplltl-drg 163 Ignicoccus hosp...
ZP_02172566   89 MMGATePVGLTCAVILEEGFPRGDLERVVASMRETAKEAGAPFVTGDTKVMGKGqvdgIVLNTTGVALADrvvsd--agl 166 Anaeromyxobacte...
Feature 1                                                                         ##             
2Z1T_A       163 rpGDAILISGSMGDHGLTILSQRQg-lNFAADVCSDSASLNRVVEKLVlev-----gdiHVLRDPTRGGLAttLNEIAgq 236 Desulfovibrio v...
2Z1U_A       163 rpGDAILISGSMGDHGLTILSQRQg-lNFAADVCSDSASLNRVVEKLVlev-----gdiHVLRDPTRGGLAttLNEIAgq 236 Desulfovibrio v...
YP_921011    173 rgGDKIVVTDYVGDHGAVILMLQMg-mGDVEEIASGSLKSDSKPLTPLlpvfekfagyiHAARDPTRGGLAgvLNEWArs 251 Thermofilum pen...
YP_001153524 167 qpGDKIVVSGYLGDHGAVILARQIg-iIDEGSGGGLVSDVKPLTRLMLplvek-ygphiHAARDPTRGGLAmaLNDWAka 244 Pyrobaculum ars...
YP_001013220 179 rdGDKIVVSGYLGDHGAAILSVREg-iGLKLEVESDVKPLTDLMIPLIerya----dyiHAAGDPTRGGLAmlLNDWAkk 253 Hyperthermus bu...
ACB07870     168 kpGDKLIVTGTIGEHGAAILSAQEg-iAVEGKLESDVNTLSKLMLPLLgayg----dkvHAAQDPTRGGLAqtLNEWAqk 242 Candidatus Kora...
YP_001040034 168 kpGDKIIVTGPIAEHGATILAAQLgmlEQAQGLRSDTRPLVKTVLPILekyr----dhiHAARDPTRGGLSivLNEWVrg 243 Staphylothermus...
YP_001056452 166 reGDKIVVTDFVGDHGGVILANRL---GLEANIISDVKPLTNLLPVLEkyr-----pyiHAARDPTRGGLAmvLNDWAka 237 Pyrobaculum cal...
YP_001435080 164 epGDKVLVTGPVGDHGATILALQFg--LQVKTLKSDVRPVWPAVKALRealg----edlKAAKDPTRGGLAmaLNELAer 237 Ignicoccus hosp...
ZP_02172566  167 raGDLLVVTGSIGDHGMAVMARRHd-lRLEGDLRSDVAPINGLVRAALaagg----edvVAMKDPTRGGVAgvLHEMAak 241 Anaeromyxobacte...
Feature 1                                                                             
2Z1T_A       237 sQAVCHVLETAVPVRESVRNGCSFLGLDPLYLANEGKLICILpeeraEAALAVLregphgeHAARIGSV 305 Desulfovibrio vulgaris
2Z1U_A       237 sQAVCHVLETAVPVRESVRNGCSFLGLDPLYLANEGKLICILpeeraEAALAVLregphgeHAARIGSV 305 Desulfovibrio vulgaris
YP_921011    252 gGLLAVIREEEVPVRDAVRRFAEMLGVDPLYLASEGAAVLSVspevaEEVVSELrgr-gfpNARVIGEF 319 Thermofilum pendens Hrk 5
YP_001153524 245 sGTVIIVEESAIPIRPQVAYYANMLGIDPLALASEGAAVLSVspdvaEEVVEFMkkl-gfdNAAIIGEV 312 Pyrobaculum arsenaticum DS...
YP_001013220 254 nGLVIAIDEAKIPVREQVRAYAELLGVDPLALASEGAAVLAVdplmaEEVVEFMrsl-gyeEATIIGEV 321 Hyperthermus butylicus DSM...
ACB07870     243 sGLFILVEERKIPMRDDVRAFTELLGIDPLALACEGRAVLGVegdsaEDVLSFIkel-gyeEASIIGEV 310 Candidatus Korarchaeum cry...
YP_001040034 244 tKYTIVINRSTIPIRDEVRQFLDALGIDPLGVAGEGLAILSVdnevaDEIVEELhrr-gepYATIIGEV 311 Staphylothermus marinus F1
YP_001056452 238 tDTVIVIDQGRVKVRDSTRAIADMAGIDPLYLASEGVAVLAVdttvaEEVVEELkka-gfpEAYIAGEV 305 Pyrobaculum calidifontis J...
YP_001435080 238 sKTTVYVEEARVPIREAVKEYAEMLGVEPLALASEGQAVFVVkgdraEEALEVLrka-gfeEAAIIGEL 305 Ignicoccus hospitalis KIN4/I
ZP_02172566  242 gGVGIVVDEPSLPVNDEVRAAGEMIGIDPLLVANEGKAVIGVrarsaDKVLAALrahplgaRATVFARA 310 Anaeromyxobacter sp. K

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