1CLI,2Z01,2BTU,2V9Y


Conserved Protein Domain Family
PurM

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cd02196: PurM 
Click on image for an interactive view with Cn3D
PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. The N-terminal domain of PurM is related to the ATP-binding domains of hydrogen expression/formation protein HypE, the AIR synthases, selenophosphate synthetase (SelD), and FGAM synthase and is thought to bind ATP.
Statistics
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PSSM-Id: 100032
View PSSM: cd02196
Aligned: 123 rows
Threshold Bit Score: 260.485
Threshold Setting Gi: 34539946
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ATPdimerization
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                           #                         
1CLI_A     40 GGLGGFGALCAlpqkyrePVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATgkldvDTA 119 Escherichia coli
ABK77778   36 HGFGHYAGMVDgg---ggMLIATHTDGVGTKVMIAGRMKKYDTVGIDCIAMNVNDVVCVGARPVSFVDYIAAskndgDIL 112 Cenarchaeum symbio...
YP_447333  36 KNKGHFAALVDfg----sRAIAMSTDGVGSKILIANLMNKFDTVGIDCIAMVVNDILCVGAEPIAMVDYLAVehpdpEVA 111 Methanosphaera sta...
O27272     36 TGAGHFAALVRmg----dVAIAMSTDGVGSKILVAEMMNRYDTVGIDCIAMVVNDILCVGARPAALVDYLAVerpdpEVA 111 Methanothermobacte...
AAU83948   45 LGIGYFANVIDlg---qgSGLAVATDGVGTKILIAQMMDKYDSVGIDCIAMNVNDILCVGAEPISLVDYIALcepdpELL 121 uncultured archaeo...
AAU83102   43 IPIGHFSGVIDlg---dgRAMAVKTDGVGTKVFIAQEMDKYDTIGIDCVAMNVNDILCVGAEPISLVDYIAVqepdpDLL 119 uncultured archaeo...
Q8TUD7     41 TGIGHYAGLLDfg----eYALAMTTDGVGSKVLIANEMKRWNTVGIDCIAMNVNDLLAIGAEPVAFVDYLALekheeGFA 116 Methanosarcina ace...
O28580     38 ILTSHYAGVIDcg----dFGITITTDGVGSKILVAEKMRKFDTIGIDCVAMNVNDLLAIGSEPLAMVDYIAIekpdeWIM 113 Archaeoglobus fulg...
CAJ37012   36 GGEGHYAGLIDmg----yFALAITTDGVGTKLLIADAIEKWDTIGIDCVAMNVNDLYVMGIEPLAFVDYISLekpnpELV 111 uncultured methano...
YP_504461  39 SEIGHFAGFISfg----kYVLAMAVDGVGTKMLVADALQDWSTVGIDCIAMNVNDLYVMNLEPVAFVDYIATselsqEQM 114 Methanospirillum h...
Feature 1                        ###                                                          
1CLI_A    120 SAVISGIAEGCLQSGCSLVGGETAEMPGmyh----geDYDVAGFCVGVVEKseiidgskvsdGDVLIALGSSGphsnGYS 195 Escherichia coli
ABK77778  113 SDIARGLARGAVKASVPIVGGETAIMPGlfsg--rgfAFDLAGTVVGLVPRkkmilgssikqGDAIIGAHSTGlhsnGYS 190 Cenarchaeum symbio...
YP_447333 112 SQIGKGLKVGCQQAKIAMIGGETASLPKii------kDFDLAGTGIGTVDKediitgtqikdGDIIIGIESSGvhsnGLS 185 Methanosphaera sta...
O27272    112 GEIGKGLAMGAEMARVAIIGGETASLPGii------rNLDLAATGIGFVDVdriitgedvspGDTVIGLESSGihsnGLS 185 Methanothermobacte...
AAU83948  122 EEIGKGLLKGAEIANITISGGEIAIVKDmvkgvrknrEFDLVGTAVGTVSLdkiivganiqeKDVIIGLSSSGihsnGLS 201 uncultured archaeo...
AAU83102  120 EAIVKGVVEGCRQARVTLSGGEIAIMPEmirgprenrGFDLVGMGVGIVSKdkiitgaaieeGDAILGLASSGihsnGMT 199 uncultured archaeo...
Q8TUD7    117 AQIGEGLLKGAEISRMSIVGGETATLPDii------kGFDLAGTCLGVVKKedileggkvrvGDVLVGIPSTGvhsnGYT 190 Methanosarcina ace...
O28580    114 AEIAKGLEEGCRIANITLLGGETATLPEii------rGFDLAGTAIGWVKKdaiitgekieeGDVIFAIPSSGihsnGLT 187 Archaeoglobus fulg...
CAJ37012  112 RQTMIGLNEGARQANVSIVGGETAALPDii------kGFDLAGTAVGVVPKdriitgkdvkpGDVIVGLPSSGihsnGYS 185 uncultured methano...
YP_504461 115 RQIGKGLNEGARQANLSILGGETATLKGlv------tGLDLAGACLGIQEKekvisgsaitpGDCMVGIPSSGihsnGLT 188 Methanospirillum h...
Feature 1                                                                                     
1CLI_A    196 LVRKILEVSgcdpqttel---dgkpladhLLAPTRIYVKSVLELie-kvDVHAIAHLTGGGFwENIPRVLpdnTQAVIDe 271 Escherichia coli
ABK77778  191 LARKALGRLplntkmn------rgtlgdaLLAPTEIYSAPVLEAas-kcKVHGLAHITGGSF-TKLPRLKd--AGFEIDa 260 Cenarchaeum symbio...
YP_447333 186 LARKALLEIanfnvddklptdnsttvgeaLLEPTIIYVDAIMDLlnsdiEVHGLGHITGGGF-SNLKRLNh-dMTYIINn 263 Methanosphaera sta...
O27272    186 LARRVFFDElelspedemp-gssssvgdeLLRPTRIYVEPIMELiesdvDVHGLAHITGGGF-GNLKRLRk-dVGYRLDs 262 Methanothermobacte...
AAU83948  202 LARHIFLKTgaidehfdv---lektigaeLLEPTHIYVPEIMEMinsnlDIKALMHITGDGF-LNLTRVKs-dVGFVIEy 276 uncultured archaeo...
AAU83102  200 LARKVLLNKfgadeyide---lgrtvgeeLLEPTNIYAREIREMldsglDLRSLAHITGDGF-LNLRRVSm-aYGFKIDn 274 uncultured archaeo...
Q8TUD7    191 LVRKIIEKSgysyhdpcpy-dssktigdeLLEPTRIYIEVLDVLka--cEVHGLAHITGSGL-LKLRRVTk--LGFEFSd 264 Methanosarcina ace...
O28580    188 LARKVVEAAglsyhdkf----gdktigeeLLTPTRIYMEILDVLre--cEVHGLAHITGSGL-LKLKRLKn--MKYVIDk 258 Archaeoglobus fulg...
CAJ37012  186 LVRKVVESAglkytdpcpy-nkkvslgeeLLTPTRIYAEVVGLAkr--fNIHGMAHITGGGL-MNLKRITs--YGFDFTd 259 uncultured methano...
YP_504461 189 LARRMVEQHgsysdrlp----sgatlgdeLLRPTRIYADAIQVCae--tAVHGMCHITGGGL-LNLNRLGe--FGYVFDa 259 Methanospirillum h...
Feature 1                                                                    
1CLI_A    272 sswqwpEVFNWLQTAgnveHHEMYRTFNCGVGMIIALpapeVDKALALLnangenAWKIGIIK 334 Escherichia coli
ABK77778  261 lp-eppEVMRLIKDRgv-sEKEMYRTFNMGVGFCVVApeseQGRIISIFkrhrirSGRIGRII 321 Cenarchaeum symbiosum A
YP_447333 264 lp-etlPIFKAIQATgi-eDKEMYHVFNMGIGFAVILdgkyQDEALEILnky-hkSYVIGEIK 323 Methanosphaera stadtmanae DSM 3091
O27272    263 lp-epqQIFRVIHEAgv-dIREMYRVFNMGVGFCAVVapddVDEALSILgd---rAHPIGEVT 320 Methanothermobacter thermautotrophi...
AAU83948  277 lp-eapPIFTLLQKRgnvtDEEMFRVYNMGIGFCVILpeqeAEAAIEIAgrhkvdAFRLGYVV 338 uncultured archaeon GZfos35A2
AAU83102  275 lp-ktpPIFELIRKHgpvsAAEMYQVYNMGIGFCIVLpadeVDSAVQIAekhgkdCYKIGSTF 336 uncultured archaeon GZfos26E7
Q8TUD7    265 pi-epqEIFKFLQKEgeveDLEMYRTFNMGMGFLMILpekdAAKAAELTg-----GKIVGKIV 321 Methanosarcina acetivorans
O28580    259 pl-kpqEIFRFIQKLgeveEAEMYRTFNMGMGFMVILpedeADKLKKLCe-----GRVVGYVE 315 Archaeoglobus fulgidus
CAJ37012  260 pl-pvpEVFKFIQKTgnieDEEMYRTFNMGMGYVIICdkqdAGAIVKMTd-----GTIVGKIV 316 uncultured methanogenic archaeon RC-I
YP_504461 260 pl-ppqEIFEWIAKAgqisEPEMYRTFNMGMGYVFILpkegVKTVQKYFp----dAQIVGHIT 317 Methanospirillum hungatei JF-1

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