1VQV,3C9R


Conserved Protein Domain Family
ThiL

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cd02194: ThiL 
Click on image for an interactive view with Cn3D
ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the conversion of this intermediate to thiamine pyrophosphate. The N-terminal domain of ThiL binds ATP and is related to the ATP-binding domains of hydrogen expression/formation protein HypE, the AIR synthases, FGAM synthase and selenophosphate synthetase (SelD).
Statistics
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PSSM-Id: 100030
View PSSM: cd02194
Aligned: 197 rows
Threshold Bit Score: 157.715
Threshold Setting Gi: 170933865
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingdimerization
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                         ###                                            # 
1VQV_B         7 GEFGLIDLIKktle-------------skviGDDTApve-ycsKKLLLTTDVLNEGVHFlrsyipeAVGWKAISVNVSDV 72  Aquifex aeolicus
3C9R_A        43 GEFGLIDLIKktle-------------skviGDDTApve-ycsKKLLLTTDVLNEGVHFlrsyipeAVGWKAISVNVSDV 108 Aquifex aeolicus
CAJ37923       7 GEIGLIRRIGkilq-------------spylGDDCAvid-ngnDYLVVTTDMLHRVTDFpremtgeDIGWMSVAVSLSDV 72  uncultured meth...
NP_615043     12 GERALISRLSgifntpegkergqegilvgagSDDCAvldlkgeDCLVVTTDMLHRTTDFppemtpwQMGWMSAAVNLSDI 91  Methanosarcina ...
YP_843516     24 GERSLISKITevlg--------------gleHDDCAvve-ldgDYLVVTTDMLHRETDFpdqatpwQIGWMSAAVNLSDI 88  Methanosaeta th...
YP_504021      2 DDRDLLEIIRpvcg-------------sdtcSDDCAilt-lpcGALVTSTDMLHERSDFpagmtgwQIGWMSVAVTISDI 67  Methanospirillu...
YP_001029879   2 DDRSLLDSIRhlig-------------edetADDCAafdlldgRILVSSTDMLHETTDFpkgmtefEKGWMSAAVTLSDI 68  Methanocorpuscu...
YP_001046395   2 DERGLHRLIGtiid-------------perlDDDCAvip-cgdRLMVASTDMLHETTDFpagmtdwQIGWMATAVTLSDV 67  Methanoculleus ...
ZP_02014996    2 NERDALRALTadl---------------phaGDDAAv-----vDDTVITTDMLHERTDFppgttryTAGWRVVGASLSDV 61  Halorubrum lacu...
YP_656888      2 DERDALGQIAktl---------------pqaGDDAAvis-ldsVSLVITTDMLHETTDFpdgttryTAGWRAVGASLSDI 65  Haloquadratum w...
Feature 1                   #                #               ###                        #        
1VQV_B        73 IANGGLPKWALISLNLpedlevsYVERFYIGVKRACEFYKCEVVGGNISKsekIGISVFLVGETer--fVGRDGAr-lGD 149 Aquifex aeolicus
3C9R_A       109 IANGGLPKWALISLNLpedlevsYVERFYIGVKRACEFYKCEVVGGNISKsekIGISVFLVGETer--fVGRDGAr-lGD 185 Aquifex aeolicus
CAJ37923      73 AGMGARPVGVVAAIGIpgdtdieFIDGIATGMRNCAKCYGTDIIGGDTDQhqeLTIVTTAFGRVnkdqvKLRSGAk-vGD 151 uncultured meth...
NP_615043     92 AAMGAEPTGLLMAIGIpadteiaFIEELAKGIQACAEFCETAVIGGDLDThaeLTITGTALGRVkkshlLLRKGAk-pGD 170 Methanosarcina ...
YP_843516     89 AAMGAEPLGVLIASGIppetdleFVEEIFEGIRDCVKAHGTEVLGGDTDAhreLTICGTALGRVsreriLRRRGAr-pGD 167 Methanosaeta th...
YP_504021     68 AAMGAEPLQIVLAIGLdt---eeRLAEIVLGAQACCDTYGAVYAGGDLDAhseLTIVSTGVGIIrd-gePVRRGGakpGD 143 Methanospirillu...
YP_001029879  69 ASCGAKPVQLLVAVGLdd---psRLVPFMEGAVSCAKTFGAKVSGGDIDShieLTVVTTGFGIVek-thYCRRSGaraGD 144 Methanocorpuscu...
YP_001046395  68 ASMGAAPGEVLLAVGLdr---peRLSGIMEGARDCCTRFGAELVGGDLDAhreLTIVSTGLGLVapehlVRRRGAr-pGD 143 Methanoculleus ...
ZP_02014996   62 AAMGAAATAAVAVYADaaf-degDLDRFVAGAIDVCEAVDAEYVGGDLDThdeFTTASTAIGDVtdagvVTRSGAr-pGD 139 Halorubrum lacu...
YP_656888     66 AAMGGQATAAVAVYGApaf-dpdEIDSFIAGAIDVCDAANAQYVGGDLDTtseLTIATTALGTVth--pSYRHGAr-iGD 141 Haloquadratum w...
Feature 1                                                                   # ##                 
1VQV_B       150 SVFVSGTLGDsraglelllxekeeyepfelaliqrhlrPTARIDYVKHIq--kYANASXDISDGlvADANHLAQRSgVKI 227 Aquifex aeolicus
3C9R_A       186 SVFVSGTLGDsraglelllmekeeyepfelaliqrhlrPTARIDYVKHIq--kYANASMDISDGlvADANHLAQRSgVKI 263 Aquifex aeolicus
CAJ37923     152 LLCVTGYLGTtaagfkvltgereaspedrqilfrsffrPEPRLGEGMILaqypGVTAMMDVSDGlgKSVYELSVASkVGF 231 uncultured meth...
NP_615043    171 LVCVTGHTGSagaaleaiqskk----svsenvlkalfePVPRTKEARKLaeseAVTSMMDTSDGlaMSLYDLARQSkVGF 246 Methanosarcina ...
YP_843516    168 LLCTTGSLGGagaglkalkig-------ridlarrllePCPRVREGIALagtgAVTAMMDNSDGlaLSLHDLAEAGgTGF 240 Methanosaeta th...
YP_504021    144 IICVTGTLGRailgltgds-----------rfwkdlcePQPRVREGTVArl-aGAHAMMDISDGlaISLYDIAAEShVGM 211 Methanospirillu...
YP_001029879 145 LVCITGTPGLamaalegde-----------ryrknlltPIPQVKAGQKIaa-aGASSMMDVSDGlsISLFDMSEASnVGF 212 Methanocorpuscu...
YP_001046395 144 VIAVTGPLGEaeaalagyd-----------rhrrellePQPRVREGQALgr-aGVSAMMDISDGlvLSLHDLLAVNdCGF 211 Methanoculleus ...
ZP_02014996  140 ALCVTGEWGRsaaalrlfkrgd----deaverandlfrFTPRVADGLALa--dRATAMMDSSDGlaRSLHQLAEASgVGF 213 Halorubrum lacu...
YP_656888    142 CICVTGNLGRtaaglkafetg-------diahanelfrFTPRVNTGAALa--kHTTAMMDSSDGlaRSVHQLASASeVGM 212 Haloquadratum w...
Feature 1                                                                        
1VQV_B       228 EILSeklplsnelkxycekygknpieyaLFGGEDYQLLFTHpk-----erWNPfldXTEIGRVE 286 Aquifex aeolicus
3C9R_A       264 EILSeklplsnelkmycekygknpieyaLFGGEDYQLLFTHpk-----erWNPfldMTEIGRVE 322 Aquifex aeolicus
CAJ37923     232 IVYAdalpvreearkv-arsrtelldmaICFGGEFELLFTVnpd---evgNIKgvdFTVIGKVT 291 uncultured methanogenic archaeo...
NP_615043    247 RIREealpilpevedf-tsdpdellefaLYTGGDFELIFTVdpgr--lkkVQNicnLTIIGECT 307 Methanosarcina acetivorans C2A
YP_843516    241 LVECeripiaeevrai-aesddealemvLRAGGDFELLLTVredm--iddARKaceLTVIGRAV 301 Methanosaeta thermophila PT
YP_504021    212 EISSgriplppea------dvqvaleaaLYGGGDFELLFFIsee----kmKNLtipVTQIGRVS 265 Methanospirillum hungatei JF-1
YP_001029879 213 ALESakfnlpdvr-------agsareyyLYGGGDFGLLFCIsre----rlPALdaeYTVIGKVV 265 Methanocorpusculum labreanum Z
YP_001046395 212 SVDTarlplpagv------pedegrelaLYGGGDFELLFTAppd----ilPVPgveARVIGEVI 265 Methanoculleus marisnigri JR1
ZP_02014996  214 ELDPdrvpvhpavdav-addpaerfelaAHFGEDFELVCTLpddavepvsETCpggLTRVGRVV 276 Halorubrum lacusprofundi ATCC 4...
YP_656888    213 SLHWdaipthpdvkey-vddvstrreltTTVGEDFELVLTLpsselanarETTsvpLHVIGEVT 275 Haloquadratum walsbyi DSM 16790

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