1FSZ,1OFU,4B45,3ZID


Conserved Protein Domain Family
FtsZ_CetZ-like
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cd02191: FtsZ_CetZ-like 
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Subfamily of FitZ and Cell-structure-related euryarchaeota tubulin/FtsZ homolog-like
FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. CetZ-like proteins are related to tubulin and FtsZ and co-exists with FtsZ in many archaea. However, a recent study found that Cetz proteins (formerly annotated FtsZ type 2) are not required for cell division. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.
Links
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Statistics
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PSSM-Id: 276960
Aligned: 4 rows
Threshold Bit Score: 331.832
Created: 5-Feb-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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nucleotideSulA
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:1FSZ: Methanocaldococcus jannaschii FtsZ with bound GDP (defined using 4.0 A contacts)
  • Citation:PMID 9722999
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###  #                                                                  
1FSZ_A     38 AKITVVGCGGAGNNTITRLKMEGie---------------gAKTVAINTDAQQLIRTka---dkKILIGkkltrglgAGG 99  Methanocaldococcus...
1OFU_A     12 AVIKVIGVGGGGGNAVNHMAKNNve---------------gVEFICANTDAQALKNIaa---rtVLQLGpgvtkglgAGA 73  Pseudomonas aerugi...
4B45_A      1 MKTVLIGVGQAGGKLASALQSFDrqtg----------fgavLDAVAVNTAKADLQSLpv----eTVLIGqdrvnghgVGG 66  Haloferax volcanii
3ZID_A      2 LNVLMLGVGQCGNRILDAVNRQAfggsrlakyyskqrfpsrVETIAINTAINDLKELkftaakdRLHVPnl----hgVGA 77  Methanosaeta therm...

Feature 1                                        ## ####                          #   #   #   
1FSZ_A    100 NPKIGEEAAKeSAEEIKAAIqd-----sdMVFITCGLGGGTGTGSAPVVAEISKKIga--lTVAVVTLPFVMEgkvRMKN 172 Methanocaldococcus...
1OFU_A     74 NPEVGRQAALeDRERISEVLeg-----adMVFITTGMGGGTGTGAAPIIAEVAKEMgi--lTVAVVTRPFPFEgrkRMQI 146 Pseudomonas aerugi...
4B45_A     67 DNELGAAVMEsDQTEVMSALdgrvtaeaeSIFVVAGLGGGSGSGGAPVLAKALAGVyd-vpVYVLGILPGADEgalYQVN 145 Haloferax volcanii
3ZID_A     78 NRSKGKQGFWeNQEMILEEIekrg--dfdLIFVMTSVSGGTGSSFSPLMIHELKKRyknatIVPIAVLPFREEgtiYLQN 155 Methanosaeta therm...

Feature 1                                          #  ##  #                                   
1FSZ_A    173 AMEGLERLKqh-tDTLVVIPNEKLFeivpn-mplklAFKVADEVLINAVKGLVELItkd---glINVDFADVKAVMNNg- 246 Methanocaldococcus...
1OFU_A    147 ADEGIRALAes-vDSLITIPNEKLLtilgkdasllaAFAKADDVLAGAVRGISDIIkrp---gmINVDFADVKTVMSEm- 221 Pseudomonas aerugi...
4B45_A    146 AGRSLKTVAre-aDAVLLVDNDAFRsage---smseGYDAINEAIARRVGLLLAAGeategvgeSVVDTSEVINTLRSg- 220 Haloferax volcanii
3ZID_A    156 AAFCLREMIeveaDGMILVDNQYLKrfsg---diasAYDRINTMVAQRLLFLIEALdse---mlSVTDLGDFKTVMNGgl 229 Methanosaeta therm...

Feature 1                                                                                     
1FSZ_A    247 GLAMIGIGEsds-------ekrAKEAVSMALNSPLLDvd----idGATGALIHVMGPed-ltLEEAREVVATVSSRldpn 314 Methanocaldococcus...
1OFU_A    222 GMAMMGTGCasg-------pnrAREATEAAIRNPLLEdvn---lqGARGILVNITAGpd-lsLGEYSDVGNIIEQFaseh 290 Pseudomonas aerugi...
4B45_A    221 GIAALGYASaeaspnaedninaVMSTTRRAVLTGTSLpd----asDADAALVVIAGEpdtipRKGVERARRWVEDEtg-s 295 Haloferax volcanii
3ZID_A    230 RMGTLGYYQadkk------spsIRAAIKNSLREVGLLypanvdagEAGRAMIVIQGSreylnVDEITKEIESLTETi--- 300 Methanosaeta therm...

Feature 1                              
1FSZ_A    315 ATIIWGATIDENlentVRVLLVITG 339 Methanocaldococcus jannaschii
1OFU_A    291 ATVKVGTVIDADmrdeLHVTVVATG 315 Pseudomonas aeruginosa
4B45_A    296 MQVRGGDFPLESg--rLASLVLLGG 318 Haloferax volcanii
3ZID_A    301 GHVFKGIVIKKGe---PRVLSVLSL 322 Methanosaeta thermophila

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