Conserved Protein Domain Family
ECT

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cd02173: ECT 
CTP:phosphoethanolamine cytidylyltransferase (ECT)
CTP:phosphoethanolamine cytidylyltransferase (ECT) catalyzes the conversion of phosphoethanolamine to CDP-ethanolamine as part of the CDP-ethanolamine biosynthesis pathway. ECT expression in hepatocytes is localized predominantly to areas of the cytoplasm that are rich in rough endoplasmic reticulum. Several ECTs, including yeast and human ECT, have large repetitive sequences located within their N- and C-termini.
Statistics
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PSSM-Id: 173924
View PSSM: cd02173
Aligned: 17 rows
Threshold Bit Score: 208.267
Threshold Setting Gi: 46229809
Created: 19-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active(T/H)XGH motif
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on sequence similarity to homologous proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #####   #  #                    ##                                        
EAK90627  215 NPNVTYIDGSFDIFHIGHLRFLERVKKIf-GGVLIIGIYDDSTAQLIYGDGfPILKMMERALTLLSMRVVDDVIFGAPIK 293 Cryptosporidium pa...
CAH76551  178 HHKVVYVDGSFDMFHLGHLKMIENARKL--GDYLLVGVYSDETVRKLKGNHfPVTSVLERTLTVLAMKGVDDVVICAPWV 255 Plasmodium chabaud...
Q99447    212 GETVIYVAGAFDLFHIGHVDFLEKVHRLaeRPYIIAGLHFDQEVNHYKGKNyPIMNLHERTLSVLACRYVSEVVIGAPYA 291 human
NP_490931 202 TDKVVYVTGSFDLFHIGHLAFLEKAKEF--GDYLIVGILSDQTVNQYKGSNhPIMSIHERVLSVLAYKPVNEVVFGAPYE 279 nematode
AAM91207  253 DARIIYIDGAFDLFHAGHVEILRRAREL--GDFLLVGIHNDQTVSAKRGAHrPIMNLHERSLSVLACRYVDEVIIGAPWE 330 thale cress
AAO60076  274 GARIVYIDGAFDCFHPGHVKILQAAKAQ--GDFLLVGLHTDEDVQARRGPHlPIMNLHERSLSVLSCKYVDEVVIGSPCV 351 Chlamydomonas rein...
AAH74341  208 EDTIIYVAGAFDLFHIGHIDFLEKVYSLveKPYVIVGLHFDQEVNHYKRKNyPIMNIHERTLSVLACRYVAEVVIGAPYS 287 African clawed frog
AAH83378  219 GDTIIYVAGAFDLFHIGHVDFLETVHGQaeKPYVIVGLHFDQEVNRYKGKNyPIMNIHERILSVLACRYVSEVVIGAPYA 298 zebrafish
EAL44415  190 QDKVIYIDGSFDLLHAGHYELFRKAHEL--GTYLIVGVYEDHTINEYKGMNyPILNIGERVMSLLACRYIDNVIIGAPRG 267 Entamoeba histolyt...
EAL48799  195 DDTIVYLDGVFDLLHIGHYKLLKHAKEI--GSYVIVGVYDDVIANKKLGINyPICNIGERVMSLLACGYVDNVVIGAPEG 272 Entamoeba histolyt...
Feature 1                    ## #                                                    ####  #  
EAK90627  294 ITKKLIETYkiNNVVSCKIIenyvssehlkknnfdsensaeyaskleEFCYEIPKKMGIFCNTtilkKEEICTNRDIFSR 373 Cryptosporidium pa...
CAH76551  256 ITESFIKRFqiDTVVRGSIAdyny-------------------snfgPDPYTVPKKLNIFKEIp---SESDMTTYEIINR 313 Plasmodium chabaud...
Q99447    292 VTAELLSHFkvDLVCHGKTEiipd--------------------rdgSDPYQEPKRRGIFRQId---SGSNLTTDLIVQR 348 human
NP_490931 280 ITSDILDQFnvQAVINGFRDnnssvv---------------nsslasIDPFAEAKRRGIYHEVd---SGSDMTTDLIIDR 341 nematode
AAM91207  331 VSRDTITTFdiSLVVHGTVAesddf------------------rkeeDNPYSVPISMGIFQVLd---SPLDITTSTIIRR 389 thale cress
AAO60076  352 ITEDLMTTFniSVVVRGSMSetsml------------------gpveEERYEVPRRMGLFTELp---SPSDVSARNIIHR 410 Chlamydomonas rein...
AAH74341  288 VSADLLDHFkvDIVCHGKTDvlpd--------------------rdgSDPYAEPKQRGIFRAVd---SGNSLTTDDIVQR 344 African clawed frog
AAH83378  299 VEKDLLDHFkvDLVCHGKTNvfpd--------------------adgTDPYAEPKKRGIFRILd---SSNNLTTDDIVQR 355 zebrafish
EAL44415  268 VTSEMIEKMhiDVVVHGKCDng-----------------------vgKEYYNDAIEKKIYQEId---SGFTLTANEIIER 321 Entamoeba histolyt...
EAL48799  273 ITKEMIEKMhiNKVLHGKHEy-------------------------nELLYKDAIEMNIMDVYd---SGSTVTALDIINR 324 Entamoeba histolyt...
Feature 1                         
EAK90627  374 IMNRRdsilyVIKKRWAKEL 393 Cryptosporidium parvum
CAH76551  314 IEKNKqyllsIISARKKKEE 333 Plasmodium chabaudi chabaudi
Q99447    349 IITNRl----EYEARNQKKE 364 human
NP_490931 342 IIHHRl----EYETRNKKKE 357 nematode
AAM91207  390 IVANHe----AYQKRNAKKE 405 thale cress
AAO60076  411 IVDKRa----AFEARNAKKV 426 Chlamydomonas reinhardtii
AAH74341  345 IIKNRl----EYEARNQKKE 360 African clawed frog
AAH83378  356 IIENRl----QFEARNQKKE 371 zebrafish
EAL44415  322 VKEREk----LFEIRNSKKQ 337 Entamoeba histolytica HM-1:IMSS
EAL48799  325 IKAMHd----TYEERNSKKQ 340 Entamoeba histolytica HM-1:IMSS

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