Conserved Protein Domain Family
RfaE_N

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cd02172: RfaE_N 
N-terminal domain of RfaE
RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in Escherichia coli, and separate proteins in other organisms. Domain I is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (this family) adds ADP to yield ADP-D-glycero-D-manno-heptose .
Statistics
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PSSM-Id: 173923
View PSSM: cd02172
Aligned: 7 rows
Threshold Bit Score: 209.58
Threshold Setting Gi: 56752220
Created: 19-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active(T/H)XGH motif
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on sequence similarity to homologous proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #####   #  #                  ##                                        
ZP_00207812  32 EAGEQVVLCHGVFDLLHMGHVRHLEAARREGTKLCVTLTGDRFVNKGPg-------RPIFPEGLRAEMLAACQYVDWVAV 104 Magnetospirillum...
YP_172921    19 DRWRPLVLTNGCFDLLHAGHVRYLQAARNLGRSLVIGLNSDASVRGIKpqpegqppRPIVPEQERAEVLAALGAVDAVVL 98  Synechococcus el...
NP_819708    24 PREKTVVMCHGVFDVVHPGHLRHLLYAKSKADILVASLTSDRHIVKGHy-------RPHIPQDLRAANLAAFEMVDYVLI 96  Coxiella burneti...
ZP_00517972  24 QEGKRIVLCHGTFDLLHPGHLAHLQEAKALGDILVVSVTAASYVNRGPg-------RPIFSDDLRLYSLASLACIDYVLL 96  Crocosphaera wat...
YP_265963    17 TKNKKIVLAHGTFDFFHHGHLQHLKKSKSIADILIVSITSDRYIKKGPn-------RPLYNQKKRAILLSHLDFVDYVVV 89  Candidatus Pelag...
NP_772062    34 AEGRTVALCHGVFDLVHLGHVRHILAARNEADVVIVTVTADRFVNKGPg-------RPIFPENMRAEMLAALGTVDWVGI 106 Bradyrhizobium j...
BAC09145     32 QDWRPLVLTNGCFDLIHAGHVRYLGAARALGKRLVVGLNSDRSVAALKp------kRPIIPEGQRAEVLASLRSVDAVVL 105 Thermosynechococ...
Feature 1                          ## #                                  ####  #        
ZP_00207812 105 NHAPTAENVLDTVRPSVYVKGSDYenpeeditgkiRAEKDAVEKHGGKLVFT-KDITFSSSTLINRYLDVYD 175 Magnetospirillum magneto...
YP_172921    99 FNEPTATELIQALQPEIYAKGGDYri-------esLPEAPAVQSYGGAIQLIaVEVPSSTSALIARIRGESA 163 Synechococcus elongatus ...
NP_819708    97 DKYPTPLQTIQALQPDLFAKGFEYisggl--hpktAEEEELLKAYGGKMLFTpGDIIYSSSALINMNEPDVR 166 Coxiella burnetii RSA 493
ZP_00517972  97 APVTAALEVIDRIQPNIYCKGHEYadasqdvthniGREIERVRAYGGDIGYT-GEIVFSSTKLINNHLNALP 167 Crocosphaera watsonii WH...
YP_265963    90 VDNPTAIEIINELKPNFYSKGIEYknhdndytnaiSLEFKALKKNKGKIVYT-NEKVMSSSNIINSIFDEEN 160 Candidatus Pelagibacter ...
NP_772062   107 NQTSSAEPILDTVRPDIYVKGSDYenpeddvtgkiATEREAVERHGGRIVFT-RDVTFSSSSLMNRYFDIYD 177 Bradyrhizobium japonicum...
BAC09145    106 FSDRTATTLIEVLQPEIYVKGGDYql-------etLPEAAAVQRYGGRIEFI-QVEVPSSTTAIVQRILELH 169 Thermosynechococcus elon...

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