1N1D,3ELB,3GLV


Conserved Protein Domain Family
cytidylyltransferase
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cd02170: cytidylyltransferase 
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cytidylyltransferase
The cytidylyltransferase family includes cholinephosphate cytidylyltransferase (CCT), glycerol-3-phosphate cytidylyltransferase, RafE and phosphoethanolamine cytidylyltransferase (ECT). All enzymes catalyze the transfer of a cytidylyl group from CTP to various substrates.
Links
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Statistics
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PSSM-Id: 173921
Aligned: 17 rows
Threshold Bit Score: 140.119
Created: 6-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1N1D_A; Bacillus subtilis GCT binds CDP-glycerol, defined using 4.0 A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ####   # ##  #               #   #   #                           #      # 
1N1D_A        1 MKKVITYGTFDLLHWGHIKLLERAKQLgdYLVVAISTDEFNLQKQkk-ayHSYEHRKLILETIRYVDEVIPEknw-eqKK 78  Bacillus subtilis
3ELB_A        7 AVRVWCDGCYDXVHYGHSNQLRQARAXgdYLIVGVHTDEEIAKHKgp-pvFTQEERYKXVQAIKWVDEVVPAapy-vtTL 84  human
YP_099113    29 NKKIYVGMTADIMHPGLIHIIHEATKYg-DVIVGLLTDKAIAEHKrl-pyLTYDQRKEVVENIKGVCEVVPQedw-syVP 105 Bacteroides frag...
NP_972019     2 EKRVYLGLTADIIHPGIINIINEGAKHg-QLIIGLLTDSAIVSHKrl-pyLTYEQRKQVVENIKGVSKVVPQedw-syIP 78  Treponema dentic...
YP_099862     4 RKKVYVGMSADIIHPGHLNIIHEAQKLg-YVTVGVLTDAAISSYKrl-pyLNYEQRSLIVKNLKGVEEVIPQstl-dyVP 80  Bacteroides frag...
YP_002135    24 ESLVLCYGHFNVIHPGHIRFLQYAKSLgkKLKVAVLGDQSIAESQrs-kyFHQMERAEGVASLHFVDLVYVLdki-slED 101 Leptospira inter...
ZP_00207812  35 EQVVLCHGVFDLLHMGHVRHLEAARREgtKLCVTLTGDRFVNKGPgr-piFPEGLRAEMLAACQYVDWVAVNhap-taEN 112 Magnetospirillum...
AAK41228     81 SKKVFVAGTFDILHPGHIEFLKEASKYg-RVYVTVARDSNSERIKgrkpiNDEQTRLEIIKSIRYVFDAILGdqe-dfLK 158 Sulfolobus solfa...
EAL49613     23 PYEVMIAGTFDLIHPGHIHFIQEAAQFg-RVIVIIARDSVVKRIKqretvLDEKMRQSIVEGIKGVSEVVLGcengnwYE 101 Entamoeba histol...
NP_558768    84 VKRVMVAGTFEIIHPGHLEYLKKAWNMg-YVIAVVSSDENAERAKkrkiiIPQQQRAEVLASLYYVHDVVLGrpg-niFD 161 Pyrobaculum aero...

Feature 1                   ## #               #                     ##  #            
1N1D_A       79 QDIIDHniDVFVMGDDw-----------EGKFDFLKDQ-CEVVYLp-------RTEGISTTKIKEEIAGL 129 Bacillus subtilis
3ELB_A       85 ETLDKYncDFCVHGNDitlt-----vdgRDTYEEVKQA-GRYRECk-------RTQGVSTTDLVGRXLLV 141 human
YP_099113   106 NLEKLKp-DYIIHGDDwktgp--lrevrEQVFEVMNAQgGKVIEIp-------YTRGINSSSLDKDIKAI 165 Bacteroides fragilis YCH46
NP_972019    79 NLKKLKp-DFIIHGDDwksgs--lskirDEVIEVMKEWgGEVIEVp-------YTKGINSSALASNMHSI 138 Treponema denticola ATCC 3...
YP_099862    81 NLELLRp-DFVVHGDDwkegv--qketrQRVIDTISKWgGKVIDVp-------YTKGISSTQLNSKLKEI 140 Bacteroides fragilis YCH46
YP_002135   102 LSVHIKp-SVLVLGKElenth--redikAAVYSIEKQN-GKVIFHa------gEVHYASADLLHGSQQDL 161 Leptospira interrogans ser...
ZP_00207812 113 VLDTVRp-SVYVKGSDyenpeeditgkiRAEKDAVEKH-GGKLVFt-------KDITFSSSTLINRYLDV 173 Magnetospirillum magnetota...
AAK41228    159 SVERINp-DIIFLGPDqkv-------deAKLLEELKKR-GLSPQIirlnerirKWSHSSTTDIINEIKKR 219 Sulfolobus solfataricus P2
EAL49613    102 PILKRNp-HLFLMGFNqpg-------dlFRFEKVIHEK-GGRTIFrrsnsmekSYSLQSSSQIRRRVIEI 162 Entamoeba histolytica HM-1...
NP_558768   162 IFHSVKp-DIVLLGPNqgv-------seSVVREEAKKR-GVEVEVirle-nlkNCELCSTTKIIEKILST 221 Pyrobaculum aerophilum str...

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