Conserved Protein Domain Family
Citrate_lyase_ligase

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cd02169: Citrate_lyase_ligase 
Citrate lyase ligase
Citrate lyase ligase, also known as [Citrate (pro-3S)-lyase] ligase, is responsible for acetylation of the (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) prosthetic group of the gamma subunit of citrate lyase, converting the inactive thiol form of this enzyme to the active form. The acetylation of 1 molecule of deacetyl-citrate lyase to enzymatically active citrate lyase requires 6 molecules of ATP. The Adenylylyltranferase activity of the enzyme involves the formation of AMP and and pyrophosphate in the acetylation reaction.
Statistics
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PSSM-Id: 173920
View PSSM: cd02169
Aligned: 16 rows
Threshold Bit Score: 421.288
Threshold Setting Gi: 42527030
Created: 7-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active(T/H)XGH motif
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on sequence similarity to homologous proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
AAF93960     34 QLTVDDDVEHFvvaygtnqIIACGGIAGHVLKSIAVSPALQGTGFalkLMTELTNFAYEMGRFSLFLFTKPANIDLFRQC 113 Vibrio cholerae ...
P77390       29 DLSVDTTVEVFitvtrdekLIACGGIAGNIIKCVAISESVRGEGLaltLATELINLAYERHSTHLFIYTKTEYEALFRQC 108 Escherichia coli...
NP_562062    43 VKSINFTVCVFnn----keLIATGSLDEYILKCFAVRSDYRKKGIsekILRILTEKAFENGETHLFIYTKPKNSKLFESL 118 Clostridium perf...
YP_050665    32 QLGMDDDIDIVvvgklggrLIACAGLASNTIKCVAVDPEFRHLNLgvqVVNEVMQQAAQRGHFHLFLYTRPENVDIFRGC 111 Erwinia carotovo...
NP_816917    34 TEALDYTVGIYdd----taLIASGSLSGKTIKCVAVCKKYQSENLltqLVVHLLEKLREENQLHSFLYTKPKNEQIFQSL 109 Enterococcus fae...
ZP_00144939  29 DKNLDYTCAMFddd---mnIVATGSCFKNTLRCLAVDNSHQGEGLmneIVTHLIDYEFSRGLTHLFLYTKNKSMKFFKDL 105 Fusobacterium nu...
CAA56214     28 QLSLEADCEMAiiaeyqqrLVGCGAIAGNVLKCIAIDPSLQGEGLslkLLTELLTLAYELGRSELFLFTKPCNAALFSGA 107 Klebsiella pneum...
YP_130483    57 DLSVDNDVEFFvvaysgtsIIGCGGIASNILKSIAITPELQGSGFslkLMSELTNYAYEMGRFHLFLFTKPSNVKFFRQA 136 Photobacterium p...
NP_721405    33 DTNLDYICAMFddd---lnIIATGSCFGNTLRCLSVDHHYQGDGLlneIVTHLINIQFERGNTHLFLYTKPDTAKFFKDL 109 Streptococcus mu...
YP_282273    32 DAHLDYTCAIMnaq---ndVIATGSYFGNSLRCLCVSSAYQGEGLlnrIVSHLIDEEYALGNYHLFVYTKTSSAAFFKDL 108 Streptococcus py...
Feature 1                                                       #####   #  #                  ##
AAF93960    114 GFflvdkvepHIALLENSPNRLSVYCkqlqll-------kmsgrKIGSIVMNANPFTLGHQYLIEQACEQCDWVHLFVVK 186 Vibrio cholerae ...
P77390      109 GFstltsvpgVMVLMENSATRLKRYAeslkkf-------rhpgnKIGCIVMNANPFTNGHRYLIQQAAAQCDWLHLFLVK 181 Escherichia coli...
NP_562062   119 GYhqlinipnLVSLLENKSTGIRTYIlnlqkk------sylqgvKVASIVMNCNPFTNGHKYLIEKASKENDVVHLFILT 192 Clostridium perf...
YP_050665   112 GFyplacfqdSAVLMENTPIGIQQYCqsltafaqpealatrtekKIGAIVMNANPFTLGHRYLAEHAAQSCDWLHVFVVR 191 Erwinia carotovo...
NP_816917   110 GFqkvv-anqEVLFMEQGKPDFADYLgyltq--------hkkagPASSIVMNANPFTKGHQYLVEKAAQESPHVYVFVLS 180 Enterococcus fae...
ZP_00144939 106 GFfeivnienQIVFMENKRAGFSDYLdnlkkd-------lkdgkNIASLIMNANPFTLGHQYLVEKASSENDILHLFIVS 178 Fusobacterium nu...
CAA56214    108 GFwpiaqagdRAVLMENSRERLTRYCrqlamy-------rqpgrKIGAIVMNANPFTLGHRWLVEQAASQCDWLHLFVVK 180 Klebsiella pneum...
YP_130483   137 GFfkianagdKLSLLENSKNGLEKYCnklkkw-------kvpgdKIASIVMNANPFTFGHQFLAEKAASECDWLHLFVVK 209 Photobacterium p...
NP_721405   110 GFyeiaradkQIVFMENKKDGFSNYLknlekp-------dsecqTTAALVINANPFTLGHQYLVEKAAAENELLHLFMVS 182 Streptococcus mu...
YP_282273   109 GFteivhidnHISFLENKKTGFQDYLmtlnkp-------eqtpgKVAAIVINANPFTLGHQFLVEKAARENDWVHLFMVS 181 Streptococcus py...
Feature 1                                                                                      #
AAF93960    187 AENKDFSYADRMAMIKAGSKHLLNLTIHSGSDYIISRATFPSYFIKDqqvv--nqsHTALDLSIFRhsIAPALGITHRFV 264 Vibrio cholerae ...
P77390      182 EDSSRFPYEDRLDLVLKGTADIPRLTVHRGSEYIISRATFPCYFIKEqsvi--nhcYTEIDLKIFRqyLAPALGVTHRFV 259 Escherichia coli...
NP_562062   193 EDKSEFSTKDRINMVKLGTKHLKNVLIHEAGKYIISSATFPSYFIKEqkni--tkaHAYLDLTLFCeyISKALNIKYRYV 270 Clostridium perf...
YP_050665   192 EDVSFFPFSERLEMVQRGVEHIHNLTVHAGSNYMISKATFPAYFLKEekli--traHAALDLIIFRkyIAPALGITQRFV 269 Erwinia carotovo...
NP_816917   181 EDKSLFSKEARFAMVQKGVAHLPNVTVLSTEDYLVSSATFPTYFLKEkaplevaaiQATLDATLFKerIAPILEIQQRYV 260 Enterococcus fae...
ZP_00144939 179 DDSSLVPFEVRKKLVIEGTKHLKNICYHETGDYIISSATFPSYFQKDevav--iesQANLDIEIFTk-IAKILNINKRYV 255 Fusobacterium nu...
CAA56214    181 EDASCFSYHDRFKLIEQGITGIDKVTLHPGSAYLISRATFPGYFLKEqgvv--ddcHSQIDLQLFRerLAPALQITHRFV 258 Klebsiella pneum...
YP_130483   210 EEGSEFSYHDRFEMIRKGTQHIQNLTLHPGSKYIISRVTFPTYFIKDkgvi--dycHTAVDLQLFRdhIAPYLGITHRYI 287 Photobacterium p...
NP_721405   183 DDSSLIPFSVRKQLILAGTEHLSNICYHETGPYIISKSIFPSYFQKDqasv--iesQARIDLAIFIq-IAKYLGIKGRYV 259 Streptococcus mu...
YP_282273   182 EDRSLIPFSVRKRLIQEGLAHLDNVIYHETGPYLISQATFPAYFQKEdndv--iksQALLDTAIFLk-IAQTLQITKRYV 258 Streptococcus py...
Feature 1       # #                                            ####  #                       
AAF93960    265 GSEPICTVTRHYNQamrrwlee-ahdasapIQVVEIERSQqa--sqPISASRVRYLLKQFGFAAIADLVPKTTYSYL 338 Vibrio cholerae O1 ...
P77390      260 GTEPFCRVTAQYNQdmrywlet-ptisappIELVEIERLRyq--emPISASRVRQLLAKNDLTAIAPLVPAVTLHYL 333 Escherichia coli K-12
NP_562062   271 GEEPFSNLTNEYNQymkei------lpkhnIQVIEVKRLKed--gqAISASSVRSFLKEGNLEKVESLVPKTTFDYL 339 Clostridium perfrin...
YP_050665   270 GTEPFCPVTYQYNQdmhywlekdqtvsspaLNVVEIERKRqts-glAISASEVRKLLKLRQYSRIQDIVPASTFEHL 345 Erwinia carotovora ...
NP_816917   261 GEEPYSEVTAVYNQamqqv-------fgqtITLTIVPRLAsd--geLISATKVRKAMAEGDKETLKKFLPATSYQYL 328 Enterococcus faecal...
ZP_00144939 256 GEEPNSLVTNIYNQtmlkk------lpennIKCIVVPRKKys--dnIISASTVRQIIKNGNLEDLKNLVPETTYNYF 324 Fusobacterium nucle...
CAA56214    259 GTEPLCPLTRNYNQrmkslle--apgdappIEVVELARIEkn--ggPVSASRVRELYRQRNWQAVAALVPPGTLSFL 331 Klebsiella pneumoniae
YP_130483   288 GTEPQCVVTNNYNQqmqqwlis-pllespkIEVIEVPRITtn--nnPISASTVRGLLIRGDTEHLADYLPKTTIEHL 361 Photobacterium prof...
NP_721405   260 GEEPTSLVTGIYNQimlqe------lpkqaIDCIVVPRKTyk--dgPISASTVRKALKEGNEQILRELLPSTSLNYF 328 Streptococcus mutan...
YP_282273   259 GEEPTSRVTAIYNEimaeq------lqqagILLDILPRKAinqqqdPISASTARQALKDNDWDLLAKLLPKTSLDYF 329 Streptococcus pyoge...

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