2QJO,2QJT


Conserved Protein Domain Family
NMNAT_Nudix

?
cd02168: NMNAT_Nudix 
Click on image for an interactive view with Cn3D
Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain
N-terminal NMNAT (Nicotinamide/nicotinate mononucleotide adenylyltransferase) domain of a novel bifunctional enzyme endowed with NMN adenylyltransferase and Nudix hydrolase activities. This domain is highly homologous to the archeal NMN adenyltransferase that catalyzes NAD synthesis from NMN and ATP. NMNAT is an essential enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. The C-terminal domain of this enzyme shares homology with the archaeal ADP-ribose pyrophosphatase, a member of the 'Nudix' hydrolase family.
Statistics
?
PSSM-Id: 173919
View PSSM: cd02168
Aligned: 8 rows
Threshold Bit Score: 279.648
Threshold Setting Gi: 50085678
Created: 21-Jan-2005
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
active site(T/H)XGH motif
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2QJO_A; Synechocystis sp. Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase with bound NAD, contacts 4A
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1        #####   #  #                  ##                                        #   #
2QJO_A      9 YGIYIGRFQPFHLGHLRTLNLALEKAEQVIIILGSHRVAADTRNPWRSPERMAMIEACLspq--ilKRVHFLTVRDwlYS 86  Synechocystis sp.
2QJT_B      9 ISVFIGRFQPFHKGHLHNIIIALQNSKKVIINIGSCFNTPNIKNPFSFEQRKQMIESDLqvagidlDTVVIEPLADyfYQ 88  Francisella tulare...
NP_641026   7 YLVFIGRFEPFHNGHAAVARHALGKAKKLIVLIGSADTPRTIRNPWTVAERAVMIESALpg---etARLLVRPLRDhlYN 83  Xanthomonas axonop...
YP_047188   6 YLVFIGRFQPFHFAHLQTIQIALQQSREVIIALGSAQPERNIKNPFLAEERQKMILANFsae--dqARIHFVNIIDv-YN 82  Acinetobacter sp. ...
YP_172016   5 VAVYIGRFQPFHNGHLSVVQRSLEVAQHLLILTGSHLASPDTRNPWSSEEREEMIRAALpan--wqKRVSFIPIRDhlYS 82  Synechococcus elon...
NP_285596   9 GAVYVGRFQPPHAAHVASVLAALEAAPRVLVLLGSANLARSVKNPFTPAEREVMFRAALtdagadlRRVTFRPLPDr-FD 87  Deinococcus radiod...
BAC89601    7 YCIYIGRFQPFHLGHLQTVRIALEEASELIIVIGSHRTAPNIKNPWTSSQREQMIRLTLkdepnllERIHFAPVRDqlYS 86  Gloeobacter violac...
NP_296148  21 YGVYIGRFEPPHQAHLLVMLEALERVQTLIVVIGSARSARTTKNPWTAHERQDVIEAMLaeagadpQRLRFVHVRDflYD 100 Deinococcus radiod...
Feature 1     #  #                          ## #    ##                  ####  #               
2QJO_A     87 DNLWLAAVQQQVLKITgg-----snSVVVLGHRKDASSYYLNLFPQWDYLETghy-pdFSSTAIRGAYfeg-------ke 153 Synechocystis sp.
2QJT_B     89 EQKWQDELRKNVYKHAkn-----nnSIAIVGHIKDSSSYYIRSFPEWDYIGVdny-knFNATEFRQKFyngi----iskq 158 Francisella tulare...
NP_641026  84 ESLWIAEVQRQVAEAVhadggtldaNIGLIGMDKDASSYYLREFPQWPLEDVqht-atLSATELRRYLfeagdigfhggl 162 Xanthomonas axonop...
YP_047188  83 DQKWVEQVKQLVNAIIes-----rsHVGLIGHFKDESSYYLKLFPEWTMVELeslkesMSATPMREAYye---------g 148 Acinetobacter sp. ...
YP_172016  83 DNLWLTEIQQKVLEEAge-----eaRIVLVGHRKDRSSYYLDLFPQWDFLEVprl-eaVHSTAIRDAYfsg------see 150 Synechococcus elon...
NP_285596  88 ADLWAADVRAVAAEIFgp-----gaSVGLVGFEKDASSSYLRWFPGWQRVNVpet-pgLNATDIRTALfe---------g 152 Deinococcus radiod...
BAC89601   87 DNLWVADIQQKVLAIAgd-----esAIAIIGHRKDESSYYLDSFPQWSYIETgny-rdIHSTDIRAAYlsr------ape 154 Gloeobacter violac...
NP_296148 101 EAHWLADVRAGVEAHTgg-----srDVALVGHIKDESSYYLRSFPDWEFLPThvv-spLNATDVRRAYfed-------rl 167 Deinococcus radiod...
Feature 1                                        
2QJO_A    154 GDYLDKVPPAIADYLQTFqks-erYIALCDEYQFL 187 Synechocystis sp.
2QJT_B    159 YMCSNDPKLGTYNFLTKFmdt-qvYQDLVAENNYV 192 Francisella tularensis
NP_641026 163 LMLRGNVPAPVYDMLEAFrrnspsYAQLVAEYRFI 197 Xanthomonas axonopodis pv. citri str. 306
YP_047188 149 KIIESAFPEGTIQFLKTFqds-eiYKQLQQKYRAQ 182 Acinetobacter sp. ADP1
YP_172016 151 SNYAAALPAGVADYLTAYqqt-grYQWLRDEADYI 184 Synechococcus elongatus PCC 6301
NP_285596 153 APLPAGLPRPVSGALGRFaht-ptCARLRREWTAV 186 Deinococcus radiodurans R1
BAC89601  155 ATYYDKLPVGVQVSLSAFqse-arFGELCAEYDFI 188 Gloeobacter violaceus PCC 7421
NP_296148 168 SDVRGMVPPAVHAFLEGFqrt-peYAELQAEFLAL 201 Deinococcus radiodurans R1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap