1LW7


Conserved Protein Domain Family
NMNAT_NadR
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cd02167: NMNAT_NadR 
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Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins
NMNAT domain of NadR protein. The NadR protein (NadR) is a bifunctional enzyme possessing both NMN adenylytransferase (NMNAT) and ribosylnicotinamide kinase (RNK) activities. Its function is essential for the growth and survival of H. influenzae and thus may present a new highly specific anti-infectious drug target. The N-terminal domain that hosts the NMNAT activity is closely related to archaeal NMNAT. The bound NAD at the active site of the NMNAT domain reveals several critical interactions between NAD and the protein.The NMNAT domain of hiNadR defines yet another member of the pyridine nucleotide adenylyltransferase
Links
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Statistics
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PSSM-Id: 173918
Aligned: 6 rows
Threshold Bit Score: 212.349
Created: 21-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site(T/H)XGH motif
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1LW7_A; Haemophilus influenzae NadR bound to NAD, defined using 4.0 A contacts.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ####   #  #  #               #    #                                        #
1LW7_A      4 VGVIFGKFYPVHTGHINXIYEAFSKVDELHVIVCSDTVRdlklfydskxkrXPTVQDRLRWXQQIFkyqknqIFIHHLVE 83  Haemophilus influe...
P27278     66 IGVVFGKFYPLHTGHIYLIQRACSQVDELHIIMGFDDTRdralfedsamsqQPTVPDRLRWLLQTFkyq-knIRIHAFNE 144 Escherichia coli K-12
NP_214726   3 HGMVLGKFMPPHAGHVYLCEFARRWVDELTIVVGSTAAE------------PIPGAQRVAWMRELFpf---dRVVHLANE 67  Mycobacterium tube...
NP_268144  16 IGIYFGTFAPLHTGHQQQIYKCASLNDGVLLVVSGYDNDrga-------qiGLPLEKRFRYLREAFnde-enIKVSMLNE 87  Lactococcus lactis...
AAV60143   11 IGIVFGTFAPMHVGHVDLITKEKRANDNVLVIVSGSNTQkdrg-----trtGLSLNRRFRNVREIFydd-elIVVDKLDE 84  Streptococcus ther...
NP_756882  14 TGLVVGKFAPLHCGHEKLINTALAQCEELFIISYSVPEMp-----------DCEPEKRLTWLQVRFpq--atILVLTPEL 80  Escherichia coli C...

Feature 1             #### ###  #                     ###                               # #   
1LW7_A     84 ------DGIPSYPNGWQSWSEAVKTLFhekh--fepSIVFSSEPqdkapy----ekylgLEVSLVdpd---rtFFNVSAT 148 Haemophilus influe...
P27278    145 ------EGMEPYPHGWDVWSNGIKKFMaekg--iqpDLIYTSEEadapqy----mehlgIETVLVdpk---rtFMSISGA 209 Escherichia coli K-12
NP_214726  68 n----pQRPWEHPDFWDIWKASLQGVLat-----rpDFVFGAEPynadf-----aqvlgARFVAVdhg---rtVVPVTAT 130 Mycobacterium tube...
NP_268144  88 ------NDLPEMPNGWDEWANRLFELIhhntlerdlSVTFYVGEleyaaelkkrfpadgNQYAVEiad---rhDISLSAT 158 Lactococcus lactis...
AAV60143   85 ------ADMPPYPEGWVPWVNRVKDLItknt-dgpeKITFYVGEseyviel--nryypqAQVELIec-----sVINISAT 150 Streptococcus ther...
NP_756882  81 varynlPAIPHNDADADIHRHYVATLClqil-rcrpHAVFTAEDygdgfan--vlarrfAQPVEHvrmarpvgDEAPSGT 157 Escherichia coli C...

Feature 1                       
1LW7_A    149 KIRTTPFQYWKFIPKEAR 166 Haemophilus influenzae
P27278    210 QIRENPFRYWEYIPTEVK 227 Escherichia coli K-12
NP_214726 131 DIRADPLGHWQHIPRCVR 148 Mycobacterium tuberculosis H37Rv
NP_268144 159 QIRENPQEHWTHINRVFR 176 Lactococcus lactis subsp. lactis Il1403
AAV60143  151 EIRDNPIENWRFITKPFR 168 Streptococcus thermophilus LMG 18311
NP_756882 158 LIRSDVHRYRYMLANDVY 175 Escherichia coli CFT073

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