1EJ2,1F9A,1HYB


Conserved Protein Domain Family
NMNAT_Archaea

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cd02166: NMNAT_Archaea 
Click on image for an interactive view with Cn3D
Nicotinamide/nicotinate mononucleotide adenylyltransferase, archaeal
This family of archaeal proteins exhibits nicotinamide-nucleotide adenylyltransferase (NMNAT) activity utilizing the salvage pathway to synthesize NAD. In some cases, the enzyme was tested and found also to have the activity of nicotinate-nucleotide adenylyltransferase an enzyme of NAD de novo biosynthesis, although with a higher Km. In some archaeal species, a number of proteins which are uncharacterized with respect to activity, are also present.
Statistics
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PSSM-Id: 173917
View PSSM: cd02166
Aligned: 16 rows
Threshold Bit Score: 254.143
Threshold Setting Gi: 18313219
Created: 21-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1EJ2_A      5 RGLLVGRMQPFHRGHLQVIKSILEEvDELIICIGSAQLSHSIRDPFTAGERVMMLTKALsengipasRYYIIPVQDIecN 84  Methanothermobacte...
1F9A_A      2 RGFIIGRFQPFHKGHLEVIKKIAEEvDEIIIGIGSAQKSHTLENPFTAGERILMITQSLkdy---dlTYYPIPIKDIefN 78  Methanocaldococcus...
1HYB_A      5 RGLLVGRMQPFHRGALQVIKSILEEvDELIICIGSAQLSHSIRDPFTAGERVMMLTKALsengipasRYYIIPVQDIecN 84  Methanothermobacte...
P57084      3 RGLYPGRFQPFHLGHLNVIKWSLERvDELIILVGSSQESHTVTNPFTAGERVEMIRNSLkdvgmdlsRIYIIPMPDIlmN 82  Sulfolobus solfata...
Q8ZX62      3 RALFPGRFQPPHWGHVYAVREILKEvDEVIITVGSAQFNYILKDPFTAGERIWMLREALreggidlsRVVIIPVPNVenN 82  Pyrobaculum aeroph...
O28784      6 RALIFGRFQPFHLGHLKVTKWALEKfDELVLLVGMANESHTVLNPFTAGERIWMMREALkdegvdlsRIITATVPTMsvY 85  Archaeoglobus fulg...
Q974L1      6 RAVFPGRFQPFHLGHLAVIEWLLSKyDELIIVVGSGKDSHTIYNPFTAGERILMIKKGLkefnvdftRVIFFPIMDSftS 85  Sulfolobus tokodaii
Q9YER8      3 RLLVVGRFQPPHLGHLHTIKWALGRaEEVIVVVGSAQESYTLENPMTAGERVHALRLMLeelddwcrRLMIAPVPDIamN 82  Aeropyrum pernix
NP_142441   3 RGLFVGRFQPVHKGHIKALEFVFSQvDEVIIGIGSAQASHTLKNPFTTGERMEMLIRALeeag-fdkRYYLIPLPDInfN 81  Pyrococcus horikos...
Q9UXN8      3 RAFYIGRFQPFHLGHYSLIKDIARDaDEVVIGIGSAQKSHEPKNPFTAGERVMMIKHALeda---giKHYAIPLEDLqrN 79  Methanolobus tinda...
Feature 1                                               #                                     
1EJ2_A     85 ALWVGHIKMLTPPFDRVYSGNPLVQRLFSEDGYEVTAPPLFYRdrYSGTEVRRRml-ddGDWRSLLPESVVEVIDEINGV 163 Methanothermobacte...
1F9A_A     79 SIWVSYVESLTPPFDIVYSGNPLVRVLFEERGYEVKRPEMFNRkeYSGTEIRRRml-ngEKWEHLVPKAVVDVIKEIKGV 157 Methanocaldococcus...
1HYB_A     85 ALWVGHIKMLTPPFDRVYSGNPLVQRLFSEDGYEVTAPPLFYRdrYSGTEVRRRml-ddGDWRSLLPESVVEVIDEINGV 163 Methanothermobacte...
P57084     83 NIWAHYVSTYTPKFEVVFARNPLVVRIFKEAGYKVEIPPAFNRekYNSTYIRRLii-lnDNWSELVPKPVYKYILEIKGD 161 Sulfolobus solfata...
Q8ZX62     83 LEWLGRVKSLAPPFQIVYTGNPFVALLFKEAGYEVRQQPMFRReqLSSTRVRELilkgdPQWEELVPKSVAAIIKAIGGA 162 Pyrobaculum aeroph...
O28784     86 VGHAFYIINLVPKVDSIITRNPVIAQVFHDAGLEVIAPPEFDRnlYRGSYIRKLml-edGNWRELVPKKVAAIIDEIGGV 164 Archaeoglobus fulg...
Q974L1     86 GLWIRNLELYSPKFDVVVSGNPLVISDAREAGYIVDLPPMFNRemYNATKIRKLmlennESWSELVPKSVYSFIKEIKGD 165 Sulfolobus tokodaii
Q9YER8     83 KVWVQYLKMLLPPFDGVVSGNELVLMLFEDMGLAALRPPMFRRgeCSGTRIRRLmasgeSGWEDCLHPQVRRYVEEIGLP 162 Aeropyrum pernix
NP_142441  82 AIWVPYVESMVPRFHVVFTGNSLVAQLFKERGYKVVVQPMFKKdiLSATEIRRRmi-agEPWEDLVPKSVVEYIKEIKGV 160 Pyrococcus horikos...
Q9UXN8     80 AVWVSHIISMTPPFDVVYSNNPLVVRLFQESGILVEQPPMYQRegYSGSEIRKRml-rgEDWKSLVPAAVIDVIDEIDGV 158 Methanolobus tinda...
Feature 1         
1EJ2_A    164 ERIK 167 Methanothermobacter thermautotrophicus
1F9A_A    158 ERLR 161 Methanocaldococcus jannaschii
1HYB_A    164 ERIK 167 Methanothermobacter thermautotrophicus
P57084    162 QRLR 165 Sulfolobus solfataricus
Q8ZX62    163 ERLR 166 Pyrobaculum aerophilum
O28784    165 ERLK 168 Archaeoglobus fulgidus
Q974L1    166 ERLR 169 Sulfolobus tokodaii
Q9YER8    163 ERLR 166 Aeropyrum pernix
NP_142441 161 ERLR 164 Pyrococcus horikoshii OT3
Q9UXN8    159 NRLK 162 Methanolobus tindarius

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