1VLH,3L92,1B6T,1O6B,1OD6,1TFU,1VLH,3F3M,3IKZ


Conserved Protein Domain Family
PPAT
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cd02163: PPAT 
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Phosphopantetheine adenylyltransferase
Phosphopantetheine adenylyltransferase (PPAT). PPAT is an essential enzyme in bacteria, responsible for catalyzing the rate-limiting step in coenzyme A (CoA) biosynthesis. The dinucleotide-binding fold of PPAT is homologous to class I aminoacyl-tRNA synthetases. CoA has been shown to inhibit PPAT and competes with ATP, PhP, and dPCoA. PPAT is a homohexamer in E. coli.
Links
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Statistics
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PSSM-Id: 173914
Aligned: 68 rows
Threshold Bit Score: 204.236
Created: 6-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site(T/H)XGH motif
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3IKZ; Burkholderia pseudomallei PPAT bound to dephosphoCoA, defined using 4.0 A contacts.
  • Structure:3L92; Yersinia pestis Phosphopantetheine Adenylyltransferase with bound CoA; contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #####     ##  #               #    #                               ###       
1VLH_F     14 KAVYPGSFDPITLGHVDIIKRALSIFDELVVLVTENPRKk--cMFTLEERKKLIEEVlsdldGVKVDVhhGLLVDYLKKH 91  Thermotoga maritima
1OD6_A      2 HVVYPGSFDPLTNGHLDVIQRASRLFEKVTVAVLENPSKrgqyLFSAEERLAIIREAtahlaNVEAATfsGLLVDFVRRV 81  Thermus thermophilus
1TFU_A      3 GAVCPGSFDPVTLGHVDIFERAAAQFDEVVVAILVNPAKt--gMFDLDERIAMVKEStthlpNLRVQVghGLVVDFVRSC 80  Mycobacterium tube...
3IKZ_A      7 VAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRAKk--pFFSLEERLKIANEVlghypNVKVMGftGLLKDFVRAN 84  Burkholderia pseud...
Q9ZBR1      3 RAVCPGSFDPITNGHLDIIARASSLYDEVYVAVMINQAKk--gLFEIEERIDLIRRVtaeygNVRVESfhGLLVDFCKQR 80  Streptomyces coeli...
YP_075268   3 KAVCPGSFDPVTLGHLDIIERAARTFDEVVVAVLTNPRKe--pLFTVEERLEMLREAtkhipNVSVAAadGLLVDFARQQ 80  Symbiobacterium th...
Q9RWM4      2 NAVFPGSFDPVTSGHMDVLTRASHMFEQVTVTVMHNARKqgrhLFTLDERLEILREAtaglpNVRVDSfsGLLVDYVAQQ 81  Deinococcus radiod...
YP_175873   3 RAICSGSFDPVTNGHIDLFERAGALFDEIIIAILINNKKk--pLFPLAERERLLRESiahikNATIDSfdGLLVDYAREK 80  Bacillus clausii K...
NP_875344   2 KVLYPGSFDPLTLGHLDLIHRASVLYEEVIIAVLENSTKs--pTFSVSRRIEQIKEStkelsKIKILSykGLTVECAKSL 79  Prochlorococcus ma...
Q8FPP9      2 KAVCPGSFDPITLGHLDIITRAAAQFEEVTVLVTANPNKns-gLFTVEERMDLIRRStahlsNVKVDTwaTLLVDYTTAH 80  Corynebacterium ef...

Feature 1           ## #      ##  #   #             #   #  #                             
1VLH_F     92 GIKVLVRGLRAVTDYEYELQMALANKKlysdLETVFLIASEKFSFISSSLVKEVALYGGDVTEWVPPEVARALNE 166 Thermotoga maritima
1OD6_A     82 GAQAIVKGLRAVSDYEYELQMAHLNRQlypgLETLFILAATRYSFVSSTMVKEIARYGGDVSKLVPPATLRALKA 156 Thermus thermophilus
1TFU_A     81 GMTAIVKGLRTGTDFEYELQMAQMNKHia-gVDTFFVATAPRYSFVSSSLAKEVAMLGGDVSELLPEPVNRRLRD 154 Mycobacterium tuberculosis
3IKZ_A     85 DARVIVRGLRAVSDFEYEFQMAGMNRYllpdVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKWLTE 159 Burkholderia pseudomall...
Q9ZBR1     81 EIPAIVKGLRAVSDFDYELQMAQMNNGls-gVETLFIPTNPTYSFLSSSLVKEVATWGGDVAHLVPPLVLEALTE 154 Streptomyces coelicolor
YP_075268  81 GCRVIVKGLRPIQDFEYEWQMGAVNRQldgnIETCFLMSRIEYAHLSSSIVRELAYFGRPTEGLVPPFTARRLRE 155 Symbiobacterium thermop...
Q9RWM4     82 GRSVIVRGLRAVSDYEYELQIAHLNRQig-eVETVFIMAATHWSFVSSSMVKEIASYGGKIHEMVPPASEAALRR 155 Deinococcus radiodurans
YP_175873  81 EATAIVRGLRSNADFEYEKNIATMNKElapqLDTLFLMTDPNYSYVSSSIVKEVASYSQDVSKLVPQPVAHALKE 155 Bacillus clausii KSM-K16
NP_875344  80 DVDFILRGLRAMSDFEYELQIAHTNRSidksIETIFLATEARHSFLSSSVVKEVAMFGGNIDHMVPAIVAKDLYK 154 Prochlorococcus marinus...
Q8FPP9     81 GIGALVKGLRSSLDYEYELPMAQMNRRls-gVDTFFLLTDEKYGYVSSTLCKEVARYGGDVSGLLPEVVVDAVKQ 154 Corynebacterium efficiens

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