1E19,2CDQ,1GS5,2AKO,2BMU,2BNE,2BUF,2J0W


Conserved Protein Domain Family
AAK
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cd02115: AAK 
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Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that phosphorylate a variety of amino acid substrates. These kinases catalyze the formation of phosphoric anhydrides, generally with a carboxylate, and use ATP as the source of the phosphoryl group; are involved in amino acid biosynthesis. Some of these kinases control the process via allosteric feed-back inhibition.
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Statistics
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PSSM-Id: 239033
Aligned: 23 rows
Threshold Bit Score: 121.01
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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nucleotidesubstrate
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:1E19; Carbamate kinase from Pyrococcus furiosus bound to ADP
  • Structure:1GS5; Escherichia coli NAGK complexed with the inert nucleotide substrate analog AMPPNP.
  • Structure:2AKO; Campylobacter jejuni glutamate 5-kinase with bound ADP
  • Comment:defined by 3.5 Angstrom contacts
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       # ###                                                                         
1E19_A      6 VIALGGNalqqrgqkgs--yeemmdnvrKTARqiaeii-argyeVVITHGNGpqvgslllhmdag--------qatygip 74  Pyrococcus furiosus
NP_747286  24 VVMLPGDgveh-------------pnfgNIVHdlvllh-slgvrLVLVHGSRpqiesrladrgltp-----hyhrgmrit 84  Pseudomonas putida...
1GS5_A      6 IIKLGGVlldse------------ealeRLFSalvnyreshqrpLVIVHGGGcvvdelmkglnlpv-----kkknglrvt 68  Escherichia coli
2BMU_B      5 VFDIGGSvlvpenp--------didfikEIAYqltkv--sedheVAVVVGGGklarkyievae------------kfnss 62  Pyrococcus furiosus
2BNE_B     13 LLKLSGEalqgtegf-----gidasildRMAQeikelv-elgiqVGVVIGGGnlfrgaglak--------------agmn 72  Escherichia coli
2BUF_E     30 VIKYGGNamese------------elkaGFARdvvlmk-avginPVVVHGGGpqigdllkrlsies-----hfidgmrvt 91  Pseudomonas aerugi...
ABA56784    3 VIKIGGSlye----------------srCLPRwlhqlatleagkAIIVPGGGpfanq----------------------- 43  Nitrosococcus ocea...
BAA32493    7 AIKVGGSlfsrkdepgsldddavtpfarNFARlaet----yrgrMVLISGGGafghgairdhds----------thafsl 72  Streptomyces wedmo...
AAT44056    3 VIKIGGSlvs---------------eilKNNDiinn----fdlnGIIVHGGGnyinefskkfgmeqrfvtspqgirsryt 63  Picrophilus torrid...
XP_637813 103 LVKIGGGvies--------------disSLIGslnflk-kiglfPIVVHGGGpqlnaelaaagepa-----eyveglrvt 162 Dictyostelium disc...

Feature 1                                                                                     
1E19_A     75 aqpmdVAGAMSQ-GWIGYMIQQALknelrkrgmekkVVTiitqtivdkndpafqnptkpvgpfydeetakrlarekgwiv 153 Pyrococcus furiosus
NP_747286  85 daatlDCVIDAV-GALRLAIEARLsmd-------iaASPmqgsrlrvasgnlvtarpig--------------------- 135 Pseudomonas putida...
1GS5_A     69 padqiDIITGALaGTANKTLLAWAkkh------qiaAVGlflgdgdsvkvtqld-------------------------- 116 Escherichia coli
2BMU_B     63 etfkdFIGIQIT-RANAXLLIAALre---------kAYPvvve------------------------------------- 95  Pyrococcus furiosus
2BNE_B     73 rvvgdHMGMLAT-VMNGLAMRDALhra------yvnARLmsaiplng--------------------------------- 112 Escherichia coli
2BUF_E     92 daatmDVVEMVLgGQVNKDIVNLInrh------ggsAIGltgkdaelirakkltvtrqtpe------------------- 146 Pseudomonas aerugi...
ABA56784   44 vrhaqKCWGISD-ACAHTMALLAMeqf------gylLQGleptlr----------------------------------- 81  Nitrosococcus ocea...
BAA32493   73 aglteATFEVKK-RWAEKLRGIGVd-----------AFPlqlaamctlr------------------------------- 109 Streptomyces wedmo...
AAT44056   64 dketlEFFIMVM-AYINYKICHILenh------gikTVSisginnrmaeasrkerlviine------------------- 117 Picrophilus torrid...
XP_637813 163 ppsvlAIAQRVF-LRENLKIVEALessg----tkarPVTqgvyqatpldpkl---------------------------- 209 Dictyostelium disc...

Feature 1                                                                                     
1E19_A    154 kedsgrgwrrvvpspdpkghveaeTIKKLVEr-gVIVIAsggggvpviledgeikgveaviDKDLAGEKLAEEVNAd-iF 231 Pyrococcus furiosus
NP_747286 136 -----vlegvdyhhtgevrrvdrkGISRLLDe-rSIVLLsplgysp--------tgeifnlACEDVATRAAIELGAd-kL 200 Pseudomonas putida...
1GS5_A    117 ---------eelghvglaqpgspkLINSLLEn-gYLPVVssigvtd--------egqlmnvNADQAATALAATLGAd--L 176 Escherichia coli
2BMU_B     96 ---------------------dfwEAWKAVQl-kKIPVXggth---------------pghTTDAVAALLAEFLKAd-lL 137 Pyrococcus furiosus
2BNE_B    113 ----------------vcdsyswaEAISLLRn-nRVVILsagtg-------------npffTTDSAACLRGIEIEAn-vV 161 Escherichia coli
2BUF_E    147 ---mtkpeiidighvgevtgvnvgLLNMLVKg-dFIPVIapigvgs--------ngesyniNADLVAGKVAEALKAe-kL 213 Pseudomonas aerugi...
ABA56784   82 ------------------laaspkEIKEVVSqqqIPIWLpatelldqp-----eipknwevTSDSLAAWLSSKLKAs-rL 137 Nitrosococcus ocea...
BAA32493  110 ---------------ngipqlrseVLRDVLDh-gALPVLagdalfde-------hgklwafSSDRVPEVLLPMVEGrlrV 166 Streptomyces wedmo...
AAT44056  118 ---rnrkmvidggytgkinkinydFLKNLVDs-gYTPVVspvafsv---------esplnvDADKMAANIAAALHAe-rL 183 Picrophilus torrid...
XP_637813 210 -----------ygfvgnvtkihtdALASCITn-dYVPVIsslamtp--------egqvlniNADVAALELAKSINPl-kI 268 Dictyostelium disc...

Feature 1         ##  ##                                                                      
1E19_A    232 MILtDVNgAAlyygt--ekeqWLREVkv-eeLRKYyeeghfk--agsmgpkVLAAIRFIEwgg---erAIIAhlekave- 302 Pyrococcus furiosus
NP_747286 201 LLFgAEPgLLdad------grLVRELrp-qqVAPHlqrlg-------sdyqGELLDAAAEackggvarSHIVsyaedgal 266 Pseudomonas putida...
1GS5_A    177 ILLsDVSgILdgk------gqRIAEMta-akAEQLieqgiit---dgmivkVNAALDAARtlg---rpVDIAswrhaeql 243 Escherichia coli
2BMU_B    138 VVItNVDgVYtadpkkdptakKIKKXkp-eeLLEIvgkgieka-gsssvidPLAAKIIARsg----ikTIVIgkedakdl 211 Pyrococcus furiosus
2BNE_B    162 LKAtKVDgVFtadpakdptatMYEQLty-seVLEKelk----------vmdLAAFTLARDhk----lpIRVFnmnkpgal 226 Escherichia coli
2BUF_E    214 MLLtNIAgLMdkq------gqVLTGLst-eqVNELiadgtiy---ggmlpkIRCALEAVQggv---tsAHIIdgrvpnav 280 Pseudomonas aerugi...
ABA56784  138 VLIkKVRlSE-----------PVISVh----SLVTrg-------------iVDAAFPRFLhsi--tipCYCItadnypqi 187 Nitrosococcus ocea...
BAA32493  167 VTLtDVDgIVtdga----ggdTILPEvdarsPEQAyaalwgssewdatgamHTKLDALVTcarr-gaeCFIMrgdpgsdl 241 Streptomyces wedmo...
AAT44056  184 LIYtNVDgIYin-------geKLSKTd----IVSLksmkig----ngmiqkVMAADIAVSsgv---reVFIGnpgn---- 241 Picrophilus torrid...
XP_637813 269 LFInTTAgMKdgd------gkVMQHIkldeqYADLmkqpwvk---hgtklkLKEFKSCLDvlp---psTSITitspdllm 336 Dictyostelium disc...

Feature 1                        
1E19_A    303 ---------alegktGTQV 312 Pyrococcus furiosus
NP_747286 267 l-----telftrgggGTLV 280 Pseudomonas putida KT2440
1GS5_A    244 p------alfngmpmGTRI 256 Escherichia coli
2BMU_B    212 f------rvikgdhnGTTI 224 Pyrococcus furiosus
2BNE_B    227 r------rvvmgekeGTLI 239 Escherichia coli
2BUF_E    281 l-----leiftdsgvGTLI 294 Pseudomonas aeruginosa
ABA56784  188 -------alkgivnmGTRI 199 Nitrosococcus oceani ATCC 19707
BAA32493  242 efltapfsswpahvrSTRI 260 Streptomyces wedmorensis
AAT44056  242 ------------iyqGTVV 248 Picrophilus torridus DSM 9790
XP_637813 337 k------elfakdgsGTTV 349 Dictyostelium discoideum AX4

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