1CCW,1I9C


Conserved Protein Domain Family
Glm_B12_BD
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cd02072: Glm_B12_BD 
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B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'-desoxyadenosyl radical, which is generated by the homolytic cleavage of the organometallic bond of the cofactor B12. Glm is a heterotetrameric molecule consisting of two alpha and two epsilon polypeptide chains.
Links
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Statistics
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PSSM-Id: 239023
Aligned: 7 rows
Threshold Bit Score: 178.426
Created: 12-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:B12 binding site [chemical binding site]
Evidence:
  • Structure:1CCW; Clostridium glutamate mutase with bound B12
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #######  #                                    ### ###                   
1CCW_C      5 TIVLGVIGSDCHAVGNKILDHAFTNAGFNVVNIGVLSPQELFIKAAIETKADAILVSSLYGQGEIDCKGLRQKCDEAGle 84  Clostridium cochle...
20138734    7 TVVLGTIGSDAHAVGITLLDHALREAGFTVHNLGAQTAKTEFATAAADHDADAVLVSSLYGHAQQDCAGLHDQLAAAGv- 85  Halobacterium sp. ...
1I9C_C      5 TIVLGVIGSDCHAVGNKILDHAFTNAGFNVVNIGVLSPQENFIKAAIETKADAILVSSLYGQGEIDCKGLRQKCDEAGle 84  Clostridium cochle...
NP_971631   6 KLVLGVIGSDCHAVGNKILDYSLTEAGFEVTNIGVLSPQEDFINAALETNADAILVSSLYGQGELDCKGLREKCDEAGlk 85  Treponema denticola
NP_602653   5 KIVIGVIGSDCHTVGNKIIHNKLEESGFDVVNIGALSPQIDFINAALETNSDAIIVSSIYGYGELDCQGIREKCNEYGlk 84  Fusobacterium nucl...
YP_135658   3 TVILGVIGSDAHVVGITILERAFEAAGFNVVNLGVQSSQSEFIDAADEHDAEAILVSSLYGHAEQDCQGFQQQINEAGl- 81  Haloarcula marismo...
AAG55064   26 TLVIGVIGADCHAVGNKVLDRVFSNHDFRVINLGVMVSQDEYIDAAIETGADAIVVSSIYGHGDIDCLGMRERCIERGlg 105 Escherichia coli

Feature 1             #                       #  #     #      
1CCW_C     85 gILLYVGGNIVVGKQHWPDVEKRFKDMGYDRVYAPGtppevGIADLKK 132 Clostridium cochlearium
20138734   86 dATTVVGGNLAVGQTDFETVKQRFEEMGFDRVFSAQtg-feAVVDAVK 132 Halobacterium sp. NRC-1
1I9C_C     85 gILLYVGGNIVVGKQHWPDVEKRFKDMGYDRVYAPGtppevGIADLKK 132 Clostridium cochlearium
NP_971631  86 gIKLFVGGNIVVGKQNFDEVHKRFTAMGFDHVYPPGtpvetTIKDLHA 133 Treponema denticola
NP_602653  85 dILLYIGGNIGSSNEKWENTEKRFKEMGFDRIYKPGtpieeTIIDLKK 132 Fusobacterium nucleatum subsp. nucleatum
YP_135658  82 dVTTYIGGNLAVGQDSFEETRETFKALGFDRVFNSEtdpeeAIEALKA 129 Haloarcula marismortui ATCC 43049
AAG55064  106 dILLYVGGNLVVGKHDFADVETKFKEMGFDRVFAPShd-leDVCQLMA 152 Escherichia coli

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