1VLH,1EJ2,1LW7,1MRZ,1N1D,2QJO,3DO8,1KAQ,1NUP,1JEE,1IHO


Conserved Protein Domain Family
cytidylyltransferase_like

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cd02039: cytidylyltransferase_like 
Click on image for an interactive view with Cn3D
Cytidylyltransferase-like domain
Cytidylyltransferase-like domain. Many of these proteins are known to use CTP or ATP and release pyrophosphate. Protein families that contain at least one copy of this domain include citrate lyase ligase, pantoate-beta-alanine ligase, glycerol-3-phosphate cytidyltransferase, ADP-heptose synthase, phosphocholine cytidylyltransferase, lipopolysaccharide core biosynthesis protein KdtB, the bifunctional protein NadR, and a number whose function is unknown.
Statistics
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PSSM-Id: 185678
Aligned: 17 rows
Threshold Bit Score: 83.2585
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site(T/H)XGH motif
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1EJ2_A; Methanobacterium Thermoautotrophicum NMNAT binds NAD and Na, defined using 4.0 A contacts
  • Structure:1VLH_F, PPAT bounds to substrate PHOSPHOPANTETHEINE

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ######  # ##  #                   ##                                         
1VLH_F     14 KAVYPGSFDPiTLGHVDIIKRALSif----dELVVLVTENprkk----------cmfTLEERKKLIEEVlsd----ldgV 75  Thermotoga maritima
1EJ2_A      5 RGLLVGRMQPfHRGHLQVIKSILEev----dELIICIGSAqlshs-------irdpfTAGERVMMLTKAlsengipasrY 73  Methanothermobacte...
1LW7_A      4 VGVIFGKFYPvHTGHINXIYEAFSkv----dELHVIVCSDtvrdlklfydskxkrxpTVQDRLRWXQQIfkyq---knqI 76  Haemophilus influe...
1MRZ_B      1 MVVSIGVFDGvHIGHQKVLRTMKEiaffrkdDSLIYTISYppeyflp---dfpgllmTVESRVEMLSRY----------A 67  Thermotoga maritima
1N1D_A      3 KVITYGTFDLlHWGHIKLLERAKQlg----dYLVVAISTDefnlqk-----qkkayhSYEHRKLILETIry-------vD 66  Bacillus subtilis
3DO8_A      2 KVALGGTFEPlHEGHKKLIDVAIKlg---grDITIGVTSDrmarar------irsvlPFAIRAENVKRYvmrk--ygfeP 70  Archaeoglobus fulg...
1IHO_A     24 VALVPTMGNL-HDGHMKLVDEAKAra----dVVVVSIFVNpmqfdr------pedlaRYPRTLQEDCEKln-------kR 85  Escherichia coli
AAF93960  152 IGSIVMNANPfTLGHQYLIEQACEqc----dWVHLFVVKAenk------------dfSYADRMAMIKAGsk------hlL 209 Vibrio cholerae O1...
YP_115616  17 PVFVLGGFEAfHLGHLKLLKIAAEin---deIVFMVIKDPsklpkn-----tkenfsDLNARIQMMANSg--------vK 80  Mycoplasma hyopneu...
NP_326379  16 ICFIIGAFESfHIGHKKLFEKALEysekdfeLVFVIVKNPadlpkn-----kaknflSFNSRIQSLVDFn--------lK 82  Mycoplasma pulmoni...
Feature 1                                                                   ###               
1VLH_F     76 KVDVhhgllvd----------------------------------------ylkkhgiKVLVRGLRavtdyeyelqm--- 112 Thermotoga maritima
1EJ2_A     74 YIIPvqdiecnalwv---------------------------------ghikmltppfDRVYSGNPlvqrl--------- 111 Methanothermobacte...
1LW7_A     77 FIHHlvedgipsypngwqsw-----------------------seavktlfhekhfepSIVFSSEPqdkapy-------- 125 Haemophilus influe...
1MRZ_B     68 RTVVldffrikdltp--------------------------------egfverylsgvSAVVVGRDfrfgknasg----- 110 Thermotoga maritima
1N1D_A     67 EVIPeknweqkk--------------------------------------qdiidhniDVFVMGDDwegkfd-------- 100 Bacillus subtilis
3DO8_A     71 EIVKitnpygk-----------------------------------------tldvdfEYLVVSPEtyemalkinq---- 105 Archaeoglobus fulg...
1IHO_A     86 KVDLvfapsvkeiypngtethtyvdvpglstmlegasrpghfrgvstivsklfnlvqpDIACFGEKdfqqlalir----- 160 Escherichia coli
AAF93960  210 NLTIhsgsdyiisratfpsyfikdqqv--------vnqshtaldlsifrhsiapalgiTHRFVGSEpictvtrhynqamr 281 Vibrio cholerae O1...
YP_115616  81 NIILfdfnaelqqlsg------------------------------ekfveiflklqvDFFVVGKNfafgknaswn---- 126 Mycoplasma hyopneu...
NP_326379  83 KLVVwdfnevssldgf------------------------------dfikklvektsdFSIIVGEDfklgkrasvn---- 128 Mycoplasma pulmoni...
Feature 1                                    #        
1VLH_F    113 -----alankklysdLETVFLiase--kfsfISSSLVKEV 145 Thermotoga maritima
1EJ2_A    112 ----------fsedgYEVTAPplfy---rdrYSGTEVRRR 138 Methanothermobacter thermautotrophicus
1LW7_A    126 ----------ekylgLEVSLVdpdr--tffnVSATKIRTT 153 Haemophilus influenzae
1MRZ_B    111 ------nasflrkkgVEVYEIedvvv-qgkrVSSSLIRNL 143 Thermotoga maritima
1N1D_A    101 ----------flkdqCEVVYLprt-----egISTTKIKEE 125 Bacillus subtilis
3DO8_A    106 ------kreelgkrkITIVKVdwmmaedgkpISSTRIKRG 139 Archaeoglobus fulgidus
1IHO_A    161 ------kmvadmgfdIEIVGVpimrakdglaLSSRNGYLT 194 Escherichia coli
AAF93960  282 rwleeahdasapiqvVEIERSqqa----sqpISASRVRYL 317 Vibrio cholerae O1 biovar eltor str. N16961
YP_115616 127 -----peqlqeffprTKIIEHlkdg---qkkISTKNLKLF 158 Mycoplasma hyopneumoniae 232
NP_326379 129 -----asdlkkhfqkVEIVEIetin---srkIATSLLKEQ 160 Mycoplasma pulmonis UAB CTIP

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