Conserved Protein Domain Family
TPP_E1_OGDC_like
?
cd02016: TPP_E1_OGDC_like 
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Links
?
Statistics
?
PSSM-Id: 238974
Aligned: 49 rows
Threshold Bit Score: 390.736
Created: 1-Dec-2004
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
TPP-binding
Feature 1:TPP-binding site [chemical binding site]
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Comment:Based on known TPP and divalent metal ion binding sites of other family members.
  • Citation:PMID 9665697
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
P20967     258 FESFLSTKFPNDKRFGLEGLESVVPgiKTLVDRSVelGVEDIVLGMAHRGRLNVLSNVVRKPNESIFSEFKGssar---- 333  baker's yeast
CAB01590   166 FDKFLSTKFPTLKRYGAEGAESMFAffSELFEGAAekQVEEIIIGIAHRGRLNLLTQLMDFPPVHMFRKIKGraef---p 242  nematode
AAH64683   184 FDHFLATKFSTVKRYGGEGAESMMGffHEMLKMCSfgGVTDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGlsef---p 260  African clawed frog
AAH02477   176 FDHFLATKFSTVKRYGGEGAESMMGffHELLKMSAysGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGlsef---p 252  human
AAN71328   178 WDNFMALKFPTVKRYGGEGAESMLAffWQLLRDSVqaNIEHVVLAMPHRGRTPLQAALLNMRPAKVFRKLGGasef---s 254  fruit fly
AAS21418   166 FDEFLALRFPDVKRYGLEGSETIMLwfDTILNEVD--KDNHVTIGMTHRGRNNLLVCLLGLRADIMFGKMSGkpefpfdp 243  Oikopleura dioica
AAH86742   182 FDHFLATKFATVKRYGGEGAESMMGffYELFRSSVysGVTDVVMGMPHRGRLNLLTGLLQFPPELMFRKMRGlsef---p 258  zebrafish
XP_424588  167 FDRFLATKFATVKRYGGEGAESMMGffHELFKMCAysGVTDIILGMPHRGRLNLLTGLLQLPPELMFRKMRGlsef---p 243  chicken
XP_396024  134 FDQFLAIKFASFKRYSGEGAESMLAfyHEFFKLCAndDLEYIVLCMPHRGRLNFLTGMLNFPLEKLFRKLQGhsef---p 210  honey bee
XP_786343    7 FDQFMTTKFATVKRYGGEGAESMMVffHQLFTQAAsdGVEDIILAMPHRGRLNLLMGPLGYSPMVMLKKLRGnpef---p 83   purple urchin

Feature 1                                           #                                          
P20967     334 ddiEGSGDVKYHLGMNYQRpttsgkyVNLSLVANPSHLESQDPVVLGRTRALLHAkndl----------kektKALGVLL 403  baker's yeast
CAB01590   243 esaDAAGDVLSHLVSSFDYkgs-egnVHVTMLPNPSHLEAVNPVAMGKARARAWSmnkgdyspd-ersaragdSVLNVLV 320  nematode
AAH64683   261 ensPSIGDVLSHLTSSVDLdfgshrpLHVTMLPNPSHLEAINPVAVGKTRARQQSlsdgdyst--essaqpgdKVVCLQV 338  African clawed frog
AAH02477   253 enfSATGDVLSHLTSSVDLdfgahhpLHVTMLPNPSHLEAVNPVAVGKTRGRQQSlqdgdysp--dnsaqpgdRVICLQV 330  human
AAN71328   255 ediEAMSDVISHFHVSEQLkil-gkkLSFSMVRNPSHLEAANPVAMGKTRSKQQArgegafgd---gsqpfgeHVLNVIL 330  fruit fly
AAS21418   244 eheKIIGDVLSHLQISSTLds----gVSVSLLPNPSHLDAINPAAMGKARSKMDHg----------------gKALCIQC 303  Oikopleura dioica
AAH86742   259 ehsPSIGDVLSHLTSTVELdfgaghpLHVTMLPNPSHLEAINPVTQGKTRGRQQVkqdgdyst--dphsrpgdKVICLQV 336  zebrafish
XP_424588  244 ensAAIGDVLSHLTSSVDLdfgshrpVHVTLLPNPSHLEAINPVAVGKTRGRQQSlldgdysp--essaqpgdKVICLQV 321  chicken
XP_396024  211 ddvATTGDVISHFVSSTNLnig-qkkLHVTMLRNPSHLEAVNPVSMGKTRGIMQAvkdgayne--dintrwsdKVLNIQI 287  honey bee
XP_786343   84 phlLCVGDIPTHLWTTVDLdvd-gkaVHLSLIPNPSHLEANIPVGIGKARGRQMSkqegdytldpsfdgchgdKVINVLL 162  purple urchin

Feature 1       ####                              # #                                          
P20967     404 HGDAAFAGQGVVYETMGFLTLPEYSTGGTIHVITNNQIGFTTDPRFARSTPYPSDLAKAIDAPIFHVNANDVEAVTFIFN 483  baker's yeast
CAB01590   321 HGDGAFTGQGVVWESIALSQAPHFRLGGTVHLVTNNQIAFTAESSVGRSSTHCTDIAKAFEYPVIHVNGDHPEEVVKATR 400  nematode
AAH64683   339 HGDASISGQGIVTETFTLSNLPHYRIGGSIHLIVNNQLGYTTPAERGRSSLYSSDVGKIVGCAVIHVNGDDPEEVLRATR 418  African clawed frog
AAH02477   331 HGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATR 410  human
AAN71328   331 HGDAAFAGQGINQECLNMAYVPHFEVGGSLHLIVNNQVGFTTPGDRGRSTAYTSDLAKSIQAPVFHVNGDDPEALARVTS 410  fruit fly
AAS21418   304 HGDGSLIGQGHNHEILNMQNIPGYDVGGSLHFCCDNQVAFTASGNLSRSCARPGDCALPYGSPVISVSASHPDQVIAAAK 383  Oikopleura dioica
AAH86742   337 HGDASFSGQGIVPETFTLSNLPHYRVGGSIHLIVNNQVGYTTPSERGRSSLYCSDVGKMVGCAIIHVNGDDAEEVLRATR 416  zebrafish
XP_424588  322 HGDGAFSGQGIVPETLTLSNLPHFRVGGSIHLIVNNQLGYTTPPERGRSSLYCSDIGKIVGCAVIHVNGDDPEEVVRATR 401  chicken
XP_396024  288 HGDAAYAAQGVDQECLALSATPHFEIGGTVHLIINNQLGFTTPTSRGRSSRYCTDLAKMISAPVIHVNGDDPEMVVRAAK 367  honey bee
XP_786343  163 HGDAAFVAQGVIAECFAMANLPHYAVGGSIHLIVNNQIGFTTPSERGRSSPYSSDIAKMNGNPVIHVNGEDPEAVLSACR 242  purple urchin

Feature 1                                             
P20967     484 LAAEWRHKFHTDAIIDVVGWRKHGHNETDQPSFTQPLMY 522  baker's yeast
CAB01590   401 LALAYRERFRKDVFINLVCFRRWGHNELDDPTFTSPVMY 439  nematode
AAH64683   419 LAVEYQRCFRKDVIIDLLCYRQWGHNELDEPFFTNPSMY 457  African clawed frog
AAH02477   411 LAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMY 449  human
AAN71328   411 LAFRYQREFRKDIFIDLNCFRRWGHNELDDPTFTNPLVY 449  fruit fly
AAS21418   384 LALRFRNKFGKDVMTELVGWRKHGHNELDDPKMTNPILY 422  Oikopleura dioica
AAH86742   417 LAVEYQRRFRKDVIVDLLCYRQWGHNELDEPFFTNPAMY 455  zebrafish
XP_424588  402 LAVEYQRHFRRDVIVDLLCYRQWGHNELDEPFFTNPSMY 440  chicken
XP_396024  368 IAFKYQRKFRKDVFVDLNCFRRWGHNELDDPVFTNPVIY 406  honey bee
XP_786343  243 LAVSYRQKFRKDVVVDLLCFRRWGHNEIDDPSFTQPIMY 281  purple urchin

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap