1POW,1V5G


Conserved Protein Domain Family
TPP_POX
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cd02014: TPP_POX 
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Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. It requires FAD in addition to TPP and a divalent cation as cofactors.
Links
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Statistics
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PSSM-Id: 238972
Aligned: 41 rows
Threshold Bit Score: 215.858
Created: 10-Nov-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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TPP-binding
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:TPP-binding site [chemical binding site]
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Structure:1POW; Lactobacillus plantarum pyruvate oxidase binds TPP and divalent metal ion; contacts at 3.5A
  • Structure:1V5G; Aerococcus viridans pyruvate oxidase binds TPP and divalent metal ion, contacts at 3.5A
  • Citation:PMID 8438155
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #                       # #                        ###
1POW_A      362 PLQAYQVLRAVNKIaePDAIYSIDVGDINLNANRHLKLTPSNRHITSNlfATMGVGIPGAIAAKLNYperQVFNLAGDGG 441 Lactobacillus pl...
NP_250798   365 PINPQRVFRSLSEQlpDDAILCGDSGSHTNWYARDIRMRPGMLGSLSGklATMGSGVPYAIAAKLAYpqrPVVAMVGDGA 444 Pseudomonas aeru...
NP_436635   364 PLKPQAAVAAFGRRiaKKGIVVTDSGQNTELAARHLDLGADHMFAVSGalASMASGLPYAIAAGIAMpdrPVYAVVGDGG 443 Sinorhizobium me...
NP_631461   365 TINPQAVAAELSARlpDDVILTADSGSGTNWWARHLLLRDGMQASLSGtlATMGPGTPYAIAARFAYperPVIAFIGDGA 444 Streptomyces coe...
NP_737734   380 PLNPDLVARAVNTRlwENTQLAIDVGSSVYHYVRHITVPRGANAHLCStlASMGCGIPYGFAAKEVTpdrPVVVMAGDGA 459 Corynebacterium ...
NP_889392   365 PVNPQRVFWELSQRlpDRSIVTADSGSAANWYARDVKLREGMMASLSGglATMGCAVPYALAAKLAYperPVVALAGDGA 444 Bordetella bronc...
NP_962189   366 PINPLRLFSELSPLlpDNAIVTADSGSSANWYARNLRFRGNMRGSLSGtlATMGPGVPYGIGAKFGQpdrPVIVFSGDGA 445 Mycobacterium av...
ZP_00169346 369 PINPQRVFVELSERlpDGCILTCDSGSAANWYARDLKIRRGMMASLSGglATMGPAVPYAIAARYAHpdrPVIAMVGDGA 448 Ralstonia eutrop...
YP_116357   366 PVNPMRVVWELSRVlpENAVVTADSGSSTNWYARCLRMRGQMRGSLSGtlATMGCGVPYALGAKFAHpdrPVVALVGDGA 445 Nocardia farcini...
ZP_00870239 415 PIRPPFIMDVLSRVipPDAIISIDVGENGWWFGRNFRTRGQKFVMSGYl-ATMGFGFPGAIAGKIAYpekPVFCITGDGG 493 Methanospirillum...

Feature 1                                      # # ##                                           
1POW_A      442 ASMt-MQDLATQVQ------YHLPVINVVFTNCQYGFIKDEQEDTnqNDFIGVEFNDI--DFSKIADGVHMQAFRVNKIE 512 Lactobacillus pl...
NP_250798   445 MQMngNAELVTVQQywq-rwDSPTFIVLVLNNGDLNQVTWEQRALagDPEFSPAQEVIdfPYARYADMLGFKGIRVDRPE 523 Pseudomonas aeru...
NP_436635   444 FAMq-LGEFATAVG------YRLPLKLLVIRNDMLNQIAWEQMMFlgNPQFACELPPI--DFAAAAEAMGGRGFTVRSFG 514 Sinorhizobium me...
NP_631461   445 FQMngMNEMITVKRyldrlsGSAPLIFCVFNNQDLNQVTWEQRAMagDPKYPGSQDIPdvPYAAYAELLGLKGIVCDDPK 524 Streptomyces coe...
NP_737734   460 MTMlgINELITVADrwk-qwEDPRFVIVVLANKDLSEVSWEQRETegEPRFEASQRVPafDFVAYAEQLGLRGIHLHDSD 538 Corynebacterium ...
NP_889392   445 MQMngINELITIADrwr-awADPTLVVLVLNNGDLNLVTWEQRVMggDPRFEDSQRLPpfAYADYARMLGLHGLRVERAQ 523 Bordetella bronc...
NP_962189   446 MQMngMAELITVKRywn-ewKDPRLIIAVLHNNDLNQVTWEMRAMagAPKFAESQNLPdvDFAAFAAGLGLNAMAIKDPD 524 Mycobacterium av...
ZP_00169346 449 MQMngINALITISRdwk-rwSGGSLTIIVLNNGDLNQVTWEQRVMegDPKFAVSQDLPvfGYAAFAQLLGLQGVRVDRPE 527 Ralstonia eutrop...
YP_116357   446 MQMngQAELLTIARyre-lwSDPRLVVCVFHNNDLNQVTWELRAMggSPKFEESQALPdvSYAELARVMGLQAVEIRDPA 524 Nocardia farcini...
ZP_00870239 494 FAMa-MGDFVTAVK------NNLPMVVIVLNNHELGMIRVEQQLEq-YPNFATSLHNP--DFVMYARSCGGDGIRVEQPD 563 Methanospirillum...

Feature 1                                     
1POW_A      513 QLPDVFEQAKAIAqhePVLIDAVITGDRPL 542 Lactobacillus plantarum
NP_250798   524 DIDAAWAEAFAADr--PVLLEVVTDPNVPP 551 Pseudomonas aeruginosa PAO1
NP_436635   515 ELDGIMDQAFAVDg--PVVIQALVDRYEPL 542 Sinorhizobium meliloti 1021
NP_631461   525 KVGAAWDEALSAGr--PVVLEFKVDAEIAP 552 Streptomyces coelicolor A3(2)
NP_737734   539 TIDQVLAEAFESDr--PVVVEAHTDADIPL 566 Corynebacterium efficiens YS-314
NP_889392   524 DLGAAWGEALTAGr--PAVLEVMTDPEMPP 551 Bordetella bronchiseptica RB50
NP_962189   525 ELSDAWRSALSADr--PTVLDVYTDPDMPP 552 Mycobacterium avium subsp. paratuberculosis str. k10
ZP_00169346 528 GIGPALDQALAARi--PTVLEMVTDPDVPP 555 Ralstonia eutropha JMP134
YP_116357   525 ELAPAWERALTADg--PVLLDVHCDPEVPP 552 Nocardia farcinica IFM 10152
ZP_00870239 564 VLEPAVKWAMNQQc--PVIVDVITDPRRFP 591 Methanospirillum hungatei JF-1

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