1QGD,1ITZ,1AY0,1R9J


Conserved Protein Domain Family
TPP_TK
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cd02012: TPP_TK 
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Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
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Statistics
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PSSM-Id: 238970
Aligned: 95 rows
Threshold Bit Score: 265.137
Created: 10-Nov-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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TPP-bindingdimer interface
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:TPP-binding site [chemical binding site]
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Structure:1QGD; Escherichia coli transketolase binds TPP and divalent metal ion; contacts at 3.5A
  • Structure:1AYO; Saccharomyces cerevisiae transketolase binds TPP and divalent metal ion; contacts at 3.5A
  • Structure:1ITZ; Maize transketolase binds TPP and divalent metal ion; contacts at 3.5A
  • Citation:PMID 9398292
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                              #                      
1QGD_B      8 NAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWrdflkhnpqnpsWADRDRFVLSNGHGSMLIYSLLHLTGYDlp-meEL 86  Escherichia coli
P06834     21 KYGRALVLDIVEQYGGGHPGSAMGAMAIGIALWkytlkyapndpnYFNRDRFVLSNGHVCLFQYIFQHLYGLKsmtmaQL 100 Pichia angusta
P47312      5 YATQHLTLNAIKHAKGGHVGMAIGASPILFSLFtkhfhfdpdqpkWINRDRFVLSAGHGSMALYSIFHFAGLIsk--qEI 82  Mycoplasma genitalium
NP_695899  15 KMAKVLSADAVEKAGSGHPGSPISLAPVAYTLYqhfikhdpndpnWEGRDRFILSGGHASLTQYVQLYFSGYGvt-ldDL 93  Bifidobacterium lo...
EAA64069   46 NVFRAFIADLVQQYGDGHPGAPMGMAAIGIALWkyvmkysptncnYFNRDRFVLSNGHACLWQYLFMHLVGVKsmtleQL 125 Aspergillus nidula...
YP_016250  12 NTLKVNGIAQILKANSGHPGIVLGAAKIMHNLFsnhinfnvenpnWINRDRFILSSGHGSALLYAQLRAIGLLdv--kEL 89  Mycoplasma mobile ...
EAL20938   34 NTIRCLAADLCQQYKGGHPGTVMGASAIGIALWryemrynplnpdWFNRDRFVLSAGHACLFQYIFLHLSGYEawtldQI 113 Cryptococcus neofo...
YP_115941  12 NSLKMHGVAAVNKANSGHPGVILSAAKMVYALYrdhmnfdvenlnWINRDRFILSAGHASGLLYSLLYNLGILeq--kDL 89  Mycoplasma hyopneu...
AAQ66751   12 DNIRVLAAAMVEKAKSGHPGGAMGGADFVNVLFseylifdpknpqWAGRDRFFLDPGHMSPMLYAQLALTGKYsm--dDL 89  Porphyromonas ging...
BAC43867   22 DTLRVLSCEMIAEAKSGHPGIALGAAPILYTLFknhlva-dptksFLNRDRFVMSAGHGSALLYAVMHLSGYDis-lnDL 99  Mycoplasma penetra...

Feature 1                                  # #                                         ##   # 
1QGD_B     87 KNFRQLh---SKTPGHPEVGKtagVETTTGPLGQGIANAVGMAIAektlaaqfn---rpghdivdhYTYAFMGDGCMMEG 160 Escherichia coli
P06834    101 KSYHSNdf-hSLCPGHPEIEHd-aVEVTTGPLGQGISNSVGLAIAtknlaatyn---kpgfdiitnKVYCMVGDACLQEG 175 Pichia angusta
P47312     83 LQHKHGq---INTSSHPEYAPnnfIDASTGPLGQGFGMAVGMVLAqkllanefk---elsdklfdhYTYVVVGDGDLQEG 156 Mycoplasma genitalium
NP_695899  94 KNFRGGa--aTRTPGHPEYGLtpgIEMTTGPLGQGFASAIGFAYGerfqrglldpetpkedspfyhKIWAICGEGDIEEG 171 Bifidobacterium lo...
EAA64069  126 KSYHSTds-sSLCPGHPEIENe-gVEVTTGPLGQGVANAVGLAMAtknlaatyn---kpgyevvnnMTWCMVGDACLQEG 200 Aspergillus nidula...
YP_016250  90 HNFRQVd---SKTPGHPEYLHtlgVEATTGPLGQGVAIAVGIALAeanlnar--------fneishFTYVLLGDGDLQEG 158 Mycoplasma mobile ...
EAL20938  114 KMYHSPatsgSMAAGHPEIEYp-gIEVTTGPLGQGISNAVGMAIAskqlaatyn---regldivdnKIWCFTGDGCLQEG 189 Cryptococcus neofo...
YP_115941  90 ENFRQMg---SKTPGHPEYGHtlgVEATTGPLGQGIAMGVGLAMAqahlhsk--------fpeinhYTYILCGDGDLQEG 158 Mycoplasma hyopneu...
AAQ66751   90 KAFRQWg---SITPGHPEVDVmhgVENTSGPLGQGHTYAVGAAIAakflahr-------fgwmmsqTIYAYISDGGIQEE 159 Porphyromonas ging...
BAC43867  100 KNFRKIn---SKTAGHPENILidgVDISTGPLGQGVGAAVGMAIAetkmnqyf-----kkynlvnyYTYCLLGDGCFQEG 171 Mycoplasma penetra...

Feature 1                            # # #                                                    
1QGD_B    161 ISHEVCSLAGTLKLGKLIAFYDDNGISIDGHveGWFTDDTAMRFEAYGWHVIRdidg-------hdaASIKRAVEEARav 233 Escherichia coli
P06834    176 PALESISLAGHMGLDNLIVLYDNNQVCCDGSvdIANTEDISAKFKACNWNVIEvena------sedvATIVKALEYAQae 249 Pichia angusta
P47312    157 VSYEVSQIAGLYKLNKLIVLHDSNRVQMDSEvkKVANENLKVRFENVGWNYIHtdd---------qlENIDQAIIKAKqs 227 Mycoplasma genitalium
NP_695899 172 ISGEAASLAANQKLGNLTVIFDANRIQIEGDtnLVLAEDVLKRFQAYGWYTDEfsfiqpdgsykediEGLADVIAKAEka 251 Bifidobacterium lo...
EAA64069  201 VGLEALSLAGHWRLNNLCVIFDNNNVTCDGTadVANTEDINTKMRATGFKVIDvydg------dsdvVAITNALLAARss 274 Aspergillus nidula...
YP_016250 159 VANEAMQFAGTNQLNKLILIHDSNRIQLDTPveNVSKVDIKKMVESFGFQHISat-----------nENFNEAVEIAKkn 227 Mycoplasma mobile ...
EAL20938  190 VGQEAISLAGHLGLDNLILVYDNNAVTVDGRidNCFTENTSKKLQAQGWNVIDvydg------sndlAAILEGFDKAKqf 263 Cryptococcus neofo...
YP_115941 159 ISYESLSLAGHLKLENLIILYDSNDIQLDSAldVVFSENVRQRIESQGLFYQLvek--------ndvNLISEAIAKAKks 230 Mycoplasma hyopneu...
AAQ66751  160 VSQGAGRIAGHLGLNNLIMFYDSNDVQLSTTvkEVASEDVAMKYRAWGWKVIEiag--------ndaDEIRKALTEAKge 231 Porphyromonas ging...
BAC43867  172 VSFEALSIAAKYKLNKLIFLYDSNDVQLEGRvaDSTVIDTKKYFESIGLNYIKvang-------ndyNEINEAILLAKks 244 Mycoplasma penetra...

Feature 1                                     #                   
1QGD_B    234 t-dkPSLLMCKTIIGFGSp-----nKAGTHDSHGAPl------GDAEIALTR 273 Escherichia coli
P06834    250 k-hrPTLINCRTVIGSGAa------FENHCAAHGNAl------GEDGVRELK 288 Pichia angusta
P47312    228 --dkPTFIEVRTTIAKNTh------LEDQYGGHWFIp------NEVDFQLFE 265 Mycoplasma genitalium
NP_695899 252 apdqPKLIKVHSLIAWPTp-----gKTNDPSSHGSKl------GTEAVAGLK 292 Bifidobacterium longum NCC2705
EAA64069  275 --tkPTFINIRTTIGVGSk------QAGTADAHGAAl------GVDEVAKIK 312 Aspergillus nidulans FGSC A4
YP_016250 228 --skPSFIEVRTIIGEDSi------EAGTTKVHGTPl------TKEDFSNLK 265 Mycoplasma mobile 163K
EAL20938  264 k-gkPSLVNIRTVIGYSSr------KANTGPAHGQAl------GDDEVAYVK 302 Cryptococcus neoformans var. neoformans B-3501A
YP_115941 231 --kkPSFIEIKTIIGEGTs------KEKTSDVHGAPl------GNDILTLKK 268 Mycoplasma hyopneumoniae 232
AAQ66751  232 g-erPTLIIGHTLMGKGAvgedgssYENMVSTHGQPlsaagasFAETVKNLG 282 Porphyromonas gingivalis W83
BAC43867  245 e-ekPTIIEIKTKIGFGSv------HEDSPKSHGAPl------SEEEIDLLK 283 Mycoplasma penetrans HF-2

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