Conserved Protein Domain Family
TPP_PK
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cd02011: TPP_PK 
Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent magnesium ions and TPP for activity.
Links
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Statistics
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PSSM-Id: 238969
Aligned: 17 rows
Threshold Bit Score: 425.595
Created: 10-Nov-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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TPP-binding
Feature 1:TPP-binding site
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Comment:Based on known TPP and divalent metal ion binding sites of other family members.
  • Citation:PMID 9665697
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                     #               
NP_822448  89 GPGHGGPAVLANSWLEGSYSETYPDISRDaAGMGKLFRQFSFPGG-VPSHVAPETPGSIHEGGELGYSLAHAYGAAFDNP 167 Streptomyces averm...
O74770    128 GPGHGAPAILSALFLEDSLGPFYPRYQFTkEGLNNLINTFSLPGG-FPSHVNAEVPGAIHEGGELGYALSVSYGAVLDRP 206 fission yeast
Q97JE3     91 GPGHGGQVMVSNSYLDGTYSEVYPNVSRDlNGLKKLCKQFSFPGG-ISSHMAPETPGSINEGGELGYSLAHSFGAVFDNP 169 Clostridium acetob...
Q8YWW1     98 GPGHGAPGILGPTYLEGTYSEVYPDKSEDeEGMLKFFKQFSFPGG-IGSHCTPETPGSIHEGGELGYSLSHAYGAAFDNP 176 Nostoc sp. PCC 7120
Q937F6     83 GPGHGGQVMVSNSYLDGTYTDIYPEITQDvEGMQKLFKQFSFPGG-VASHAAPETPGSIHEGGELGYSISHGVGAILDNP 161 Lactobacillus pent...
XP_325978 104 GPGHGAPAVLSQAYLEGTYSEVYPEISEDeEGMQKFFKHFSFPGG-IGSHATPETPGSIHEGGELGYSISHAFGAVFDHP 182 Neurospora crassa
EAK84552  124 GPGHGAPAILSCLYLEGSISKFYPEESVShQGLHAFVRNFSWPNTvRPSHVTATTPGAIHEGGELGYALSVAHGAVMDKP 203 Ustilago maydis 521
YP_007004  92 GPGHGGPGIVANTYLEGTYSEYYPHISQDaEGMQKLFKQFSFPGG-IPSHVAPETPGSINEGGELGYSLSHAFGAAFNNP 170 Parachlamydia sp. ...
YP_114037 106 GPGHGAPGVLGPLYLEGSYSEIYPDKDLSeEGLLNFFKQFSFPGG-IGSHCTPETPGSIHEGGELGYVLSHACGAAFDNP 184 Methylococcus caps...
AAW46259  100 GPGHGAPAVLSQSYLEGVYTEVYPNITEDvEGMRRFFKQFSFPGG-VGSHATPETPGSLHEGGELGYSISHAFGTVFDNP 178 Cryptococcus neofo...

Feature 1             ####                              # #                                   
NP_822448 168 DLLVACVIGDGEAETGPLAASWHSNKFLDPVHDGAVLPILHLNGYKIANPTVLSRIPEPELDELLRGYGHEPLHVTGddp 247 Streptomyces averm...
O74770    207 DLIVTCVVGDGEAETGPTATSWHAHKFLDPAESGAVIPVLELNGYKISERTIYGCMDDSELLSLFSGFGYEVAIVNDtp- 285 fission yeast
Q97JE3    170 DLITACVVGDGEAETGPLATSWQANKFLNPVTDGAVLPILHLNGYKISNPTVLSRIPKDELEKFFEGNGWKPYFVEGedp 249 Clostridium acetob...
Q8YWW1    177 DLIVTAVIGDGEAETGPLATAWHSNKFINPIRDGAVLPILHLNGYKIANPTILARISHEELEDLFKGYGYTPYFVEGhdp 256 Nostoc sp. PCC 7120
Q937F6    162 DEIAAVVVGDGESETGPLATSWQSTKFINPINDGAVLPILNLNGFKISNPTIFGRTSDEKIKQYFESMNWEPIFVEGddp 241 Lactobacillus pent...
XP_325978 183 NLIALTMVGDGEAETGPLATSWHSTKFLNPITDGAVLPVLHLNGYKINNPTILARISHKELENLFRGYGYEPYFVEGddv 262 Neurospora crassa
EAK84552  204 DLIAFAVIGDGEAETGPTATAWHSHKFIDPCESGAVLPILHLNRFKISEKTIFGTMDRTELLALFVGYGYQVRFVDYyqh 283 Ustilago maydis 521
YP_007004 171 DLIVGCVIGDGEAETGPLATAWHSNKFLNPAIDGAVLPILHLNGYKIANPTILARISQEELKSLFVGYGYKPYFVEGsdp 250 Parachlamydia sp. ...
YP_114037 185 DLIVAAVVGDGEAETGPLATSWHINKFLNPIRDGAVLPILNLNGYKINNPTLLARISHEELENLLRGYGYTPYFVEGsep 264 Methylococcus caps...
AAW46259  179 NLITLTMVGDGESETGPLAASWHSTKFLNPITDGAVLPVLHLNGYKINNPTVLARISHEEIEALFIGYGWKPYFVEGsdl 258 Cryptococcus neofo...

Feature 1                                                                                     
NP_822448 248 -------------hqVHRALAEAFDRALDrVALMQRTAREEGatERIRWPMIVLRTPKGWTGPAEVDGRPVEGTWRAHQV 314 Streptomyces averm...
O74770    286 --------------dQNRVMAATMDWAVErIHDIQHRARVNReeIKPRWPMIILRTPKGKGCPKYLNGKFLEGTFRAHQV 351 fission yeast
Q97JE3    250 -------------etMHKLMAETLDIVTEeILNIQKNARENNdcSRPKWPMIVLRTPKGWTGPKFVDGVPNEGSFRAHQV 316 Clostridium acetob...
Q8YWW1    257 -------------aqVHQLMAATLETVILeIKKIQTEARTSGvaKRPRWPMIVLRTPKGWTAPAEIDGHKLEGFWRSHQV 323 Nostoc sp. PCC 7120
Q937F6    242 -------------ekVHPALAKAMDEAVEkIKAIQKNARENDdaTLPVWPMIVFRAPKGWTGPKSWDGDKIEGSFRAHQI 308 Lactobacillus pent...
XP_325978 263 -------------dtMHQAMAATLEHCVLeIRKFQQKARESGkaFRPRWPVIILRSPKGWTGPRKIDDKFLEGFWRAHQV 329 Neurospora crassa
EAK84552  284 lgtkhtipgdheataFDVDMAASLDWALSeIDNIQKAARQAEaqKKPRWPMIILTSPKGWGAPVQVDGQQIEGSFRSHQV 363 Ustilago maydis 521
YP_007004 251 -------------qlMHRLMAETLDMIIKeIQEIQTNARKNGivKRPIWPMIILRTPKGWTGPKEVDGKKTENYWRSHQV 317 Parachlamydia sp. ...
YP_114037 265 -------------esMHQAMAATVDRSIEdIRAAQTEARASGiaRRPRWPMIVLRSPKGWTAPRQIDGHNVEGFWRAHQV 331 Methylococcus caps...
AAW46259  259 -------------tsMHQAMAATLEKAVLeIKAYQKQARDSGkaFRPRWPMIILRSPKGWTAPRNVSGHHLEGYWRAHQI 325 Cryptococcus neofo...

Feature 1      
NP_822448 315 P 315 Streptomyces avermitilis MA-4680
O74770    352 P 352 fission yeast
Q97JE3    317 P 317 Clostridium acetobutylicum
Q8YWW1    324 P 324 Nostoc sp. PCC 7120
Q937F6    309 P 309 Lactobacillus pentosus
XP_325978 330 P 330 Neurospora crassa
EAK84552  364 P 364 Ustilago maydis 521
YP_007004 318 P 318 Parachlamydia sp. UWE25
YP_114037 332 P 332 Methylococcus capsulatus str. Bath
AAW46259  326 P 326 Cryptococcus neoformans var. neoformans JEC21

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