1OZH


Conserved Protein Domain Family
TPP_ALS
?
cd02010: TPP_ALS 
Click on image for an interactive view with Cn3D
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2 molecules of pyruvate to acetolactate and carbon dioxide. ALS does not contain FAD, and requires TPP and a divalent metal cation for activity.
Links
?
Statistics
?
PSSM-Id: 238968
Aligned: 16 rows
Threshold Bit Score: 294.196
Created: 9-Nov-2004
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
TPP-bindingdimer interface
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:TPP-binding site [chemical binding site]
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Structure:IOZH; Klebsiella pneumoniae acetolactate synthase binds thiamine-diphosphate and divalent metal ion; contacts at 3.5A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                            ####                      # #                        ###   
1OZH_D      373 PLRIVRAMQDIVNSDVTLTVDMGSFHIWIARYLYTFRARQVMISNGQQTMGVALPWAIGAWLVNPERKVVSVSGDGGFLQ 452 Klebsiella pneum...
NP_252869   359 PQRLVADVRRALPSQGIVALDNGMYKIWFARNYKAHMPNTVLLDNALATMGAGLPSAMAAHLVYPDRPIVAVCGDGGFMM 438 Pseudomonas aeru...
NP_487595   358 PQKLIYDLRQVMGPDDIVISDVGAHKMWIARHYHCHSPNTCIISNGFAAMGIAIPGALAAKLVYPNRKVVAATGDGGFMM 437 Nostoc sp. PCC 7120
ZP_00280676 362 PVRIVNDVYETTPVDGIVCLDNGMYKIWFARYYRAHEPNSLLLDNALASMGAGLPSAIATKIVHPDRKVMAVCGDGGFMM 441 Burkholderia fun...
Q04789      377 PLEIVKELRNAVDDHVTVTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGDGGFLF 456 Bacillus subtilis
NP_350234   379 PQKVLYDLRRVMGEDDIVISDVGAHKMWIARNYHCYKPNTCIISNGFASMGIAIPGALAAKLVNPDKKVVAVTGDGGFMM 458 Clostridium acet...
ABB40648    358 PQKIIWDLRTAMNREDIAICDVGAHKMWMARFFRSELPNTCIISNGFASMGIAVPGAIGAKLAFPEKAIVAVTGDAGFMM 437 Thiomicrospira c...
AAM04770    360 PQEIVQSVRKVLGREDIISLDNGIYKLWFSRLYKAYAPNTVLLDNALATMGAGFSAGLVAKLLHPERRVLAVCGDGGFMM 439 Methanosarcina a...
BAB53323    357 PQRIVHDVRAVMPADGILALDNGMYKIWFARNYRTRMANTLLLDNALATMGAGLPSAMMASLLFPTRRVMAICGDGGFMM 436 Mesorhizobium lo...
ZP_00379093 350 PQRIVAEVREVMPVDGIVALDNGMYKIWFARNYRTTRANTLLLDNALATMGAGLPSAMAAKLTYPERRVMAVVGDGGFMM 429 Brevibacterium l...

Feature 1                            # # ##                                                     
1OZH_D      453 SSMELETAVRLKANVLHLIWVDNGYNMVAIQEEKKy--QRLSGVEFGPMDFKAYAESFGAKGFAVESAEALEPTLRAAMD 530 Klebsiella pneum...
NP_252869   439 NSQELETAVRLKMNLTVIILRDNGYGMIRWKQSNMg--FADFGLDYGNPDFVHYAEAYGAHGHRVDSAEGFLPLLERCLG 516 Pseudomonas aeru...
NP_487595   438 NCQELETALRVGTPFVTLIFNDGGYGLIEWKQENQfgkGQSSFVHFGNPDFVKLAESMGLKGYRVESALDLIPVLKEALA 517 Nostoc sp. PCC 7120
ZP_00280676 442 NSQELETAVRLRLDLVILILRDDAFGMIRWKQENMn--FPDYGMTLSNPDFVAYAQSYGAKGHRIETAAEFAPLLRECFA 519 Burkholderia fun...
Q04789      457 SAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKy--NRTSAVDFGNIDIVKYAESFGATGLRVESPDQLADVLRQGMN 534 Bacillus subtilis
NP_350234   459 NSQELETALRIGTPFVTLIFNDSNYGLIKWKQEERy--GESAYINFTNPDFKMYAESMGLKGYRITKAEELIPTLEEAFS 536 Clostridium acet...
ABB40648    438 NSQEIETALRCNTPIVILIWNDNQYGLINWKQKRRy--GRSAYIDFQNPDFVKYAESFGATGVRINSANELLPALKTALK 515 Thiomicrospira c...
AAM04770    440 NCQELETAIRYKIPLVVLILNDNAFGFIKWKQKKLh--FEDFALDCGNPDFVRFAESFGATGLKVEEGDDLSEVLEKAFF 517 Methanosarcina a...
BAB53323    437 NSQELETAVRLKLNLVILLLEDHAYGMIRWKQAVDe--FPDFGMTFGNPDFVKYAEAYGAKGTRVTEIADLRPALERAFT 514 Mesorhizobium lo...
ZP_00379093 430 NSQEMETAVRLGLDLVVLVLEDSSYGMIRWKQAVDg--MPDYGLTFGNPEFVAYAESYGATGHRLENVDDMHDVLESAFA 507 Brevibacterium l...

Feature 1                   #      
1OZH_D      531 VDGPAVVAIPVDYRDNPLL 549 Klebsiella pneumoniae
NP_252869   517 TPGVHVIDCPVDYSENDRI 535 Pseudomonas aeruginosa PAO1
NP_487595   518 QDVPAVIDCPVDYRENRRF 536 Nostoc sp. PCC 7120
ZP_00280676 520 TPGVHVIDLPIDYSDNERV 538 Burkholderia fungorum LB400
Q04789      535 AEGPVIIDVPVDYSDNINL 553 Bacillus subtilis
NP_350234   537 QKVPSVIDCAVDYSENLKL 555 Clostridium acetobutylicum ATCC 824
ABB40648    516 ANTVTIIDCPVDYSENDRL 534 Thiomicrospira crunogena XCL-2
AAM04770    518 LNKLVAIECPIDYSVNYET 536 Methanosarcina acetivorans C2A
BAB53323    515 GGGVHLVVVPIDYSENTRV 533 Mesorhizobium loti MAFF303099
ZP_00379093 508 AGGVHLVVVPVDYSENERV 526 Brevibacterium linens BL2

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap