Conserved Protein Domain Family
TPP_SHCHC_synthase
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cd02009: TPP_SHCHC_synthase 
Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting isochorismate and 2-oxoglutarate to SHCHC, pyruvate and carbon dioxide. The enzyme requires TPP and a divalent metal cation for activity.
Links
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Statistics
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PSSM-Id: 238967
Aligned: 47 rows
Threshold Bit Score: 155.446
Created: 9-Nov-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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TPP-binding
Feature 1:TPP-binding site
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Comment:Based on known TPP and divalent metal ion binding sites of other family members.
  • Citation:PMID 9665697
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  #                    
NP_280000   394 EIAATVAAGAPDp------aTVFVSNSMPIRDFdrfaap-----rgadlaVLGNRGASGIDGVVSSALGAGSAtaDPVVG 462 Halobacterium sa...
BAC76188    372 LSEPGVLRMCFQya----kpLIFVGNSMPIRDAnhfvech---hlhdpvhVFANRGVSGIDGNLATSMGVSYAlqEPLMC 444 Cyanidioschyzon ...
YP_098600   368 SAIGSLIQALPAs------cALHLANSSAVRYAqlysl-------pdtveVCCNRGTSGIEGSLSTAIGYAAAskKLNFV 434 Bacteroides frag...
NP_970217   347 DSEQGMIYAISKrmk---gsSVYLGNSLPIREWdssssh-----dfpparVAANRGANGIDGQISTFLGWAHPe-LENWC 417 Bdellovibrio bac...
YP_008067   345 LAELSLFHLLSKkip--eesKIYVGNSLPIREWdqaadw-----tnkhfqVFANRGANGIEGQLSTFLGLASPe-QNNWA 416 Parachlamydia sp...
NP_905665   384 KAFEVILRHIPHd------aALHAANSTPVRYLqlfeha------hyaggEWSNRGTNGIEGATSTAMGFSEVysGTTLL 451 Porphyromonas gi...
NP_695441   358 FSNVAIAQYMSSrvparstvQLAILNSLRVWDLfnye---------dsisFFSNVGAFGIDGGMSTLIGQSFAtdDLCLM 428 Bifidobacterium ...
AAF12986    388 LSEPAVVRSLLQhwp--enyVGYLGPSMPIRDSdifcegntqdstnstinLYSNRGASGIDGNIGTSLGISVGtkQKVLS 465 Cyanidium caldarium
ZP_00310506 369 TAVFDVLNHLPAf------aKLHLANSMSVRYAntlgis------qrnaeVFANRGTSGIDGVISTAYGYALKtsQLVTI 436 Cytophaga hutchi...
ZP_00950874 392 SAYKCLLEKLPNn------sLVHLSNSSTIRYAqlfql-------nktidVFCNRGTSGIDGSTSTAIGASLVskKQTIL 458 Croceibacter atl...

Feature 1         ####                         # #                                              
NP_280000   463 LVGDLAYFHDSNGLLALERc-gVDATIVLVNNDGGSIFHMLPie-----qFDPPFTGQFktp-hglDFAPTADTy---AL 532 Halobacterium sa...
BAC76188    445 ILGDLAFLHDLTSLHLLRQl-tKHIWVIVINNQGGGIFELIPn------vFNHYFHHHD-------HFEHVAKQf---DF 507 Cyanidioschyzon ...
YP_098600   435 VIGDLSFFYDMNALWNNHFg--SNLRILLLNNGGGEIFHTLPglemsgtsHRFVTAVHKt------SAKGWAEEr---GF 503 Bacteroides frag...
NP_970217   418 LVGDLTALYDLSSLWVTSQldaKKFRVVVINNGGGQIFHRMFk-------KEIFINKHQi------SFESWAKMw---NW 481 Bdellovibrio bac...
YP_008067   417 ILGDLTTLYDMIAPWVIHQiqpLKVNVVVVNNSGGQIFAPKFa-------HLSFLNSHQl------NFKAFADFw---GW 480 Parachlamydia sp...
NP_905665   452 ITGDLSFMYDSNALWMPYVn--GRIRVIVMRNGGGGIFRFIPgp-----dSLKELETCFetp-levPVREMAGAy---GW 520 Porphyromonas gi...
NP_695441   429 VTGDLAFLYDINSLSIRGIk--NNVRVLLINNNGGFEFKLGVg-------HDKDVDRYIaa---sgHFKTASGWvcdcGF 496 Bifidobacterium ...
AAF12986    466 LLGDLSFLHDINSLKVVDKl-pDKPILVIYNNNGGAIFSFLQin----niHKDVLTKFFyaphnlsTFEHIAYQf---SL 537 Cyanidium caldarium
ZP_00310506 437 ITGDLAFFYDRNAFWNNYKp--SNLRVVLLNNHGGGIFRMIDgp-----sALPELDELFetk-qtlSARYLATEh---GL 505 Cytophaga hutchi...
ZP_00950874 459 ITGDLSFFYDSNALWNTYIp--NSFRIILINNNGGGIFRILPgh-----eETETFNTYFett-hnlTAKQLCKMy---NF 527 Croceibacter atl...

Feature 1                                              
NP_280000   533 SFARtdtvGEFRAAYRAalg-------daGTHVIEVSTD 564 Halobacterium salinarum NRC-1
BAC76188    508 HYYAvnnwYELALHLQNt----------kGANLIEIQTN 536 Cyanidioschyzon merolae strain 10D
YP_098600   504 LYQE----VQDEKQLDEamktftqpelltQPVIMEVFTN 538 Bacteroides fragilis YCH46
NP_970217   482 SYDKwhtiPEDNKELNLa-----------DHQIIELSPN 509 Bdellovibrio bacteriovorus HD100
YP_008067   481 EYDCw---HEIPTTILGs----------qTSRLIELVPD 506 Parachlamydia sp. UWE25
NP_905665   521 RYMKavsaEELETVLPSffa------sgdRAVLLEVETP 553 Porphyromonas gingivalis W83
NP_695441   497 RYMSassmDEFKQQCEEfla------dsaEPIVMEVFVS 529 Bifidobacterium longum NCC2705
AAF12986    538 NYKKiqniYALVKLLNLygn-------knEAIILEIESS 569 Cyanidium caldarium
ZP_00310506 506 EYTLcknlNGLNQALESffq------psmFGKILEIETD 538 Cytophaga hutchinsonii
ZP_00950874 528 KYENatstEEIQHSLETffd------eadAPKLLEIFTP 560 Croceibacter atlanticus HTCC2559

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