Conserved Protein Domain Family
TPP_Gcl
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cd02006: TPP_Gcl 
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the condensation of two molecules of glyoxylate to give tartronic semialdehyde and carbon dioxide. This enzyme requires TPP, magnesium ion and FAD as cofactors.
Links
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Statistics
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PSSM-Id: 238964
Aligned: 3 rows
Threshold Bit Score: 438.638
Created: 9-Nov-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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TPP-binding
Feature 1:TPP-binding site [chemical binding site]
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Comment:Based on known TPP and divalent metal ion binding sites of other family members.
  • Citation:PMID 9665697
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #                     
P30146    363 THFDNVPVKPQRVYEEMNKAFGRDVCYVTTIGLSQIAAAQMLHVFKDRHWINCGQAGPLGWTIPAALGVCAADPKRNVVA 442 Escherichia coli O...
NP_630304 363 THFDDIPIKPQRVYEEMNKAFGPETRYVSTIGLSQIAGAQMLHVYRPRHWINCGQAGPLGWTVPAALGVAKADPDAQVVA 442 Streptomyces coeli...
BAB47877  363 THFDQVPLKPQRVYEEMNKAFGRDVTYVTTIGLSQIAGAQFLHVYKPRNWINCGQAGPLGWTLPAALGVRAADPERTIVA 442 Mesorhizobium loti...

Feature 1       ####                        # #                                               
P30146    443 ISGDFDFQFLIEELAVGAQFNIPYIHVLVNNAYLGLIRQSQRAFDMDYCVQLAFENINsse--vngYGVDHVKVAEGLGC 520 Escherichia coli O...
NP_630304 443 LSGDYDFQFMLEELAVGAQHRIPYVHVLVNNSYLGLIRQAQRAFDIDFQVNLEFENINspe--lgvYGVDHVKVAEGLGC 520 Streptomyces coeli...
BAB47877  443 LSGDYDFQFMIEELAVGAQHKLPYIHVVVNNAYLGLIRQAQRGFSMDYEVSLAFENINrsgdpeagYGVDHVAVAEAMGC 522 Mesorhizobium loti...

Feature 1                                                 
P30146    521 KAIRVFKPEDIAPAFEQAKALMAQYRVPVVVEVILERVTNISMG 564 Escherichia coli O157:H7
NP_630304 521 KAIRVTDPNELGAALEQAKKLAAEHRVPVVVEAILERVTNISMS 564 Streptomyces coelicolor A3(2)
BAB47877  523 KAVRVRKPEEFAGAFREAQRLMKEHRVPVVLEFILERVTNISMG 566 Mesorhizobium loti MAFF303099

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