1BFD,1MCZ


Conserved Protein Domain Family
TPP_BFDC
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cd02002: TPP_BFDC 
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Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This enzyme is dependent on TPP and a divalent metal cation as cofactors.
Links
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Statistics
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PSSM-Id: 238960
Aligned: 51 rows
Threshold Bit Score: 118.467
Created: 4-Nov-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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TPP-bindingdimer interface
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:TPP-binding site [chemical binding site]
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Structure:1BFD; Pseudomonas putida benzoylformate decarboxylase binds TPP and divalent metal ion; contacts at 3.5A
  • Structure:1MCZ; Pseudomonas putida benzoylformate decarboxylase binds TPP and divalent metal ion; contacts at 3.5A
  • Citation:PMID 9665697
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                ##                       # #                           
1BFD        353 LHPETVFDTLNDMAPEn-AIYLNESTSTTAQMWQrlnmrnpgSYYFCAA-GGLGFALPAAIGVQLAep------------ 418 Pseudomonas putida
CAD70458    408 YGTGHLCRRLRALCPEd-TIWAIEAVTNTLFVHDniqptlpgSWINCGG-GGLGWSGGGALGIKLAteveak-------- 477 Neurospora crassa
NP_961934   384 DAPDAMLAALGGALPDd-AVVVQEAVTNRPAVARqvr--rppGQLFDTGaPALGWALGGAFGIKLArp------------ 448 Mycobacterium av...
NP_344516   360 IHPKYLSYEIGIVASEynLVIFNEYQFNPRYARLne----fgSYFADLSvGYLGFALGAGVGYKIAt------------- 422 Sulfolobus solfa...
ZP_01013483 387 MTKDWVSLCLGRALKGrrASVFHELGCPLQPLDLdq----pdSYFQEPFsGGLGWGMPAAIGAKMAdp------------ 450 Rhodobacterales ...
ZP_00861305 421 INPAYLFARLQALLSEd-DIVVNEAVRNAPVLQQqlrrtkpmTYVGLAG-GGLGFSGGMALGLKLAnp------------ 486 Bradyrhizobium s...
BAE54630    397 CTVDYLCSRIRASVPQd-TIYITDSVTNQVPMTEqlqltrpgSHLTKGG-SGLGWSGGAAIGASLAtarydisdrpnlhl 474 Aspergillus oryzae
EAL89013    381 VTVPYLSSRLRQHLPDd-TVIVIEAVTNAIPIIHhlnltkpgSLYGSGA-GGLGWGGGAALGVKMAkr------------ 446 Aspergillus fumi...
ZP_01000282 385 FTAEAASAVLAERLPRe-SVIVNEYSFRTDLAKFdg----egQFYGFTPaGGLGFGMGAALGIAAAdare---------- 449 Oceanicola batse...
CAI09357    384 MSAAYVAAQLNEVIAEg-DIVVHEAITNVLPVLTqikrnrpgTLFGNGG-GGLGFGGGAALGAKLAcp------------ 449 Azoarcus sp. EbN1

Feature 1                    ####  #                       # # ##                               
1BFD        419 -----eRQVIAVIGDGSANYSISALWTAAQy--nIPTIFVIMNNGTYGALRWfagvl------------eaenvPGLDVP 479 Pseudomonas putida
CAD70458    478 akrgkgKFVVQIVGDGTFLFSVPGSVYWISkrygIPVLTIVLNNKGWNAPRRslllvhpdgl---gskasnadiNIEFSP 554 Neurospora crassa
NP_961934   449 -----hAPVVAICGDGSFNFGVPTAALWSAhrygAPFVTVVLNNHSYLASKTpvtelypqg----isvrdndfpETRLTP 519 Mycobacterium av...
NP_344516   423 -----nKDVLITTGDGSFIFGVPEAFYYVAs--kYPTMVVIYDNGGWLASAEavdevfpeg----lakskkyypGADFDR 491 Sulfolobus solfa...
ZP_01013483 451 -----dRLVVATVGDGSYMFANPTACHFVAeaqnVPVIVLVLNNEEWAAVRYsvqglypeg----esktanevpLTSLRP 521 Rhodobacterales ...
ZP_00861305 487 -----sHRVVQIVGDGAFHFAAPDSVYAVSqqyrLPIFSVILDNKGWQAVKAsvqrvypdgvaqqtdsflsrlaTGRQDE 561 Bradyrhizobium s...
BAE54630    475 nettktPFICNIIGDGSFVFSVPTAVYWAAhryqTPFLTVILNNGGWNATRQcladvhpsgv--aaglsnrdlgISLVED 552 Aspergillus oryzae
EAL89013    447 -----dSFICAIVGDGTYLFSQMESVYWIArrydVPFLLVVLNNSGWNAPKVstllvhsdgl---asksnrgdmNLSFEP 518 Aspergillus fumi...
ZP_01000282 450 --gvrdRPVVAMLGDGAYMFNNPVACHWASaahqLPMLSVIFNNRRWGAVRNstlamypqg----aaaasdgmfLADLSP 523 Oceanicola batse...
CAI09357    450 -----eRTVFHITGDASFCFSAPTPVYMVAkqckLPIFTIVLDNAGWGAVKGatlrvypdg-----aaraagayQALVGE 519 Azoarcus sp. EbN1

Feature 1                                                          
1BFD        480 GIDFRALAKGYGVQALKAdn---leQLKGSLQEAls----akGPVLIEVST 523 Pseudomonas putida
CAD70458    555 SPDYAGIAKAAAGGDLFAaridntaDLDRVLKEAiaav-eggQSAVLDCKV 604 Neurospora crassa
NP_961934   520 ETDYAALARACGGSGRDVht---paQMREAIGWAldea-gqgRCAVLDVRL 566 Mycobacterium avium subsp. paratuberculosis s...
NP_344516   492 RFEIGKTVETFHGYYELVed---pwEIKPALIRGlekmrrenKIAVIQVIV 539 Sulfolobus solfataricus P2
ZP_01013483 522 SPDFAKVAEASRAYTETVtd---grDLPAALERAirvaekeqRQVLLNIAI 569 Rhodobacterales bacterium HTCC2654
ZP_00861305 562 QRRLVDIARAFGAHGERVdd---pdELDAAIRSClaal-ddgRAAVLHVNI 608 Bradyrhizobium sp. BTAi1
BAE54630    553 GPDYGEVAKAAANGNLWTkrvrsvgELDVVLREGirvvveerKSVVLDIVI 603 Aspergillus oryzae
EAL89013    519 SPDYPGIAAAAGNAWGATvtk--tdQVDSTLKKAvet---vqGGRCAVVEV 564 Aspergillus fumigatus Af293
ZP_01000282 524 APDYAAICRAHGGSGETVns---arDLPGAIDRAltam-aggQQALIDLVI 570 Oceanicola batsensis HTCC2597
CAI09357    520 DIRYEKVGEAAGAYGEWVde---paELPGAIGRCmrel-adgRSAILVARI 566 Azoarcus sp. EbN1

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