1FX5,1RIT,1QOT,2E6V


Conserved Protein Domain Family
lectin_L-type

?
cd01951: lectin_L-type 
Click on image for an interactive view with Cn3D
legume lectins
The L-type (legume-type) lectins are a highly diverse family of carbohydrate binding proteins that generally display no enzymatic activity toward the sugars they bind. This family includes arcelin, concanavalinA, the lectin-like receptor kinases, the ERGIC-53/VIP36/EMP46 type1 transmembrane proteins, and an alpha-amylase inhibitor. L-type lectins have a dome-shaped beta-barrel carbohydrate recognition domain with a curved seven-stranded beta-sheet referred to as the "front face" and a flat six-stranded beta-sheet referred to as the "back face". This domain homodimerizes so that adjacent back sheets form a contiguous 12-stranded sheet and homotetramers occur by a back-to-back association of these homodimers. Though L-type lectins exhibit both sequence and structural similarity to one another, their carbohydrate binding specificities differ widely.
Statistics
?
PSSM-Id: 173886
View PSSM: cd01951
Aligned: 45 rows
Threshold Bit Score: 85.9438
Threshold Setting Gi: 223938960
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:1FX5_A; Ulex europeus lectin I (UE-I) binds Ca2+ and Mn2+ which are required for carbohydrate binding activity.
    View structure with Cn3D
  • Structure:2E6V_A; The exoplasmic/luminal domain of Canis lupus familiaris VIP36 lectin binds Ca2+.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
1FX5_A          4 LSFKFknfs-----qngkDLSFQGNASVie------tGVLQLNkvgnnlpdeTGGIARYIAPIhiwncntgelasFITSF 72   furze
1RIT_D          4 VSFNFnsfs-----egnpAINFQGDVTVls------nGNIQLTnln---kvnSVGRVLYAMPVriwssatgnvasFLTSF 69   peanut
YP_002430384   21 FSLTIacllfa--naafaGWAVNGDAQWlyqg--tvnEQILLTeei----gdQAGSAWIETQIdld-------ydFDISF 85   Desulfatibaci...
ZP_05041853   437 YRLNVtsqtcd--aaisaNLSLSGSATRnt-----ssNEITLTqds----gnQSGSAWSQNRIsll-------spFTVEF 498  Alcanivorax s...
ZP_01252839    29 FLLVIlccvnq--adaqlNAQVTGDAIDqg------nNCYTITqdq----efQVGGVWYNNPIdfd-------tdFTIFY 89   Psychroflexus...
EDX86918      165 FTTHVyahalaalpdvdeIFTINGNASRts------aNEIRLTena----ngQSGSAYSNARIdfn-------fdWDFTF 227  Synechococcus...
ZP_01689785     5 FSSLIglllft-hqvfaqEFHTIEDAVKme------nGCIMLTadk----pyQRGIAYCKTKLdls-------kyFEIEF 66   Microscilla m...
1QOT_D          6 LSFNFdkfv-----pnqkNIIFQGDASVst------tGVLQVTkvsk-ptttSIGRALYAAPIqiwdsitgkvasFATSF 73   furze
ZP_03630846    52 TDFNSgv---------paGSAVFGNAVVstnggfsnsGCLKLTttt----asQTGTFVITNDLdagq----pvvsFTASF 114  bacterium Ell...
ZP_01720270     7 AQVGFpycetfdsnttksTTVFGADAQLv-------dGALRLTgnt----lnQRGYVYIDIPFssa-------ygIKASF 68   Algoriphagus ...
Feature 1                                                                    # #                  
1FX5_A         73 SFFMetsanpkaaTDGLTFFLAppdsplrraggyf-------glfndtkcdssyqTVAVEFDTigspvn----------- 134  furze
1RIT_D         70 SFEMkdik-dydpADGIIFFIApedtqipagsigg-------gtlgvsdtkgaghFVGVEFDTysnsey----------- 130  peanut
YP_002430384   86 SIYLgdrd--sngADGISFALQndpagtsafgdts-------gggewigmngicpSVSVEVDTwqnsnr----------- 145  Desulfatibaci...
ZP_05041853   499 SIYLgtkd--asgADGIAFAFQnddagssatgvf----------ggalgvggldpAVAVEFDTysnggg----------- 555  Alcanivorax s...
ZP_01252839    90 QNNFgsrd--ldgADGMALVFKdnptpilgdpg------------gglgysgitpSLTIEFDTfqnadf----------- 144  Psychroflexus...
EDX86918      228 DLYFgtn---dggADGIGFVLHndpdgdravgls----------ggglgiagverSVGIEFDTffnsgt----------- 283  Synechococcus...
ZP_01689785    67 DIYLgkkn--dngADGITFVIHndtrgfraigtwgecmgygrwnrgyyggnyiapSVAVEFDTyqnyrq----------- 133  Microscilla m...
1QOT_D         74 SFVVkadk--sdgVDGLAFFLApansqipsgssagm-----fglfsssdskssnqIIAVEFDTyfgkayn---------- 136  furze
ZP_03630846   115 KALVggg----saADGFSFNFApdlpfgvfp----------------lgeegagtGLTVEFDTflntt------------ 162  bacterium Ell...
ZP_01720270    69 EYFSygg----dgADGMTFFLFdanvpnfaiggfggs---lgyskrdtepglagaYMGVGFDEygnfgstaegksggfpg 141  Algoriphagus ...
Feature 1                 #                                                                       
1FX5_A        135 -fwdpgfPHIGIDVNcv--------------ksINAERWNKrygl----nnvANVEIIYea-ssKTLTASLtypsdqtsi 194  furze
1RIT_D        131 --ndpptDHVGIDVNsv--------------dsVKTVPWNSvsg------avVKVTVIYds-stKTLSVAVtndng-dit 186  peanut
YP_002430384  146 --gdpaaDHVGINVYtqsgstcs---gtpnhpgAGPTQADPsssni-edgdeHDLRITWna-ttHVMTVYFdgt-----q 213  Desulfatibaci...
ZP_05041853   556 -ygdianDHTVIYDPvnytsnn-----gggsllSPVVDLGNied-----ggwHTVSLDWdp-vsNQLQYRFdga-----l 618  Alcanivorax s...
ZP_01252839   145 --gdpagDHISIMRNgnpnhnls---tnlagpvLAIDTNPDied-----giaHDVRIEWda-stNTLSVFFdcl-----l 208  Psychroflexus...
EDX86918      284 --sdissDHTSILDPete------------ssfTSPSALPNled-----gnyHTVVVSWda-gaQTLSYSIdsi-----d 338  Synechococcus...
ZP_01689785   134 --ndptcDHVAYLENgtn-------------yhTKYWNNKDtrfnl-edgvlHNFRFRWep-tiQQVTVYLdnv-----v 191  Microscilla m...
1QOT_D        137 -pwdpdfKHIGIDVNsi--------------ksIKTVKWDWrng------evADVVITYra-ptKSLTVCLsypsdgtsn 194  furze
ZP_03630846   163 ---dpndAAPSIDVKvgg-------------feVATASFPGira-----nafVDVVIQLnp--dSTLDVYYdg------v 213  bacterium Ell...
ZP_01720270   142 agpnltpNAIVIRGPgngftgydfikgkktmesGPDGLASDqffpissggigTQRVTDYnkpgyRKVNLTLnpspsgvgy 221  Algoriphagus ...
Feature 1                                                                     
1FX5_A        195 sVTSIvdlke------------------ilpewVSVGFSGSTYig-rqATHEVLNWYFTS 235  furze
1RIT_D        187 tIAQVvdlka------------------klperVKFGFSASGSlg-grQIHLIRSWSFTS 227  peanut
YP_002430384  214 rLTYTsdiintv---------------fggdnmVYFGFAASTGgs--yNEQYIIPNTPDV 256  Desulfatibacillum alkenivorans AK-01
ZP_05041853   619 vAVVNrdftsld---------------fagdpnVFFGFTGSTGgs--sNLQKVCVIDAPP 661  Alcanivorax sp. DG881
ZP_01252839   209 rLTFTdnvkdti---------------fsgdnsVFFGFVGSTGgd--tNIHEVCFNRVSF 251  Psychroflexus torquis ATCC 700755
EDX86918      339 iDSLTqdlitsd---------------fggsnlIYWGFGAATGgs--tNEHRVRVQTFNG 381  Synechococcus sp. PCC 7335
ZP_01689785   192 vHRGKrdlvkdi---------------fkgntkAIWGFTASTGnk--hNLQFFCLRRWAQ 234  Microscilla marina ATCC 23134
1QOT_D        195 iITASvdlka------------------ilpewVSVGFSGGVGnaaefETHDVLSWYFTS 236  furze
ZP_03630846   214 pVYTNlfvsl------------------spttgGHFGFGARTGgq--nDNHFIDNLNITT 253  bacterium Ellin514
ZP_01720270   222 lISMVmeytveeniprsitifqdvpypypapanLKLGFSASTGgl--tNFHEIRNLLVEV 279  Algoriphagus sp. PR1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap