1W25,3BRE,3EZU,2V0N


Conserved Protein Domain Family
GGDEF

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cd01949: GGDEF 
Click on image for an interactive view with Cn3D
Diguanylate-cyclase (DGC) or GGDEF domain
Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.
Statistics
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PSSM-Id: 143635
View PSSM: cd01949
Aligned: 825 rows
Threshold Bit Score: 80.2932
Threshold Setting Gi: 207084904
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the active site is formed at the diguanylate cyclase dimerization interface
  • Structure:1W25: Response regulator PleD in complex with Cyclic Di-GMP
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   #  ##    #   #                     
1W25_A     289 VTDQLTGLHNRRYMTGQLDSlvkra---tlggdPVSALLIDIDFFKKINDTF-GHDIGDEVLREFALRLASNVra----i 360  Caulobacter vibr...
NP_970745  361 AKSNLQGEANFTLNSTTLTQkidniiinmnadeEVYLLYLDIDKFKTINQLW-GYYAGNALIQHIYSMILAHIksfnipe 439  Treponema dentic...
NP_213995  641 THNVETGLLNKVGFQKVLSPllgk------lssTGALIALDMVGFSRLIKEF-GEEAIKKLLKEIAVRLEKTFrr----g 709  Aquifex aeolicus...
EDZ63478   236 YIDKATKLRNRKYLIDKLPEylkid----atskGGINMMIALSGIIEANEKI-GHQQVDKFFLAIANIFDAHAsny--dn 308  Campylobacterale...
EDZ62830   185 IFDNKFGVYNKRYLMTKIEQevel-----itefKHKSSLIMIELSRELKDSVsNEKAITLMTRTIARLLLKTSrr----s 255  Campylobacterale...
CAJ74182   944 LIDELTMIFNHRYFQIRLVQetlra---erynlPLALILFDIDHFDNYVARK-GEYYGNLVIKKTSGLVKKNTrg----s 1015 Candidatus Kuene...
EDZ62594   154 SVDALTKASNKMHMTSIIKTnlkkir--dgqikSFSLMYIDVDDFNAFIRAN-GINATDATIKKIAMIIKRSIrd----k 226  Campylobacterale...
CAJ74890   587 VMDEFQGIYNKRYFTELLTKqlava---krrdeNLSLLILGPDNHKATTETYgSNNAGNLLLQQIAGVLSDSVsn----s 659  Candidatus Kuene...
NP_952722  154 RIDTLTGVYNRRYLDERLSPeikra---yryerALSLILVGINDFSGITSAH-GHYAGELALKGCADVLAESIrr---di 226  Geobacter sulfur...
EDX90084    95 REDHLTGLFNRPHLLGMLERelals---qrhnyTVSILLIEIEDFTQLLDSY-GRHTGEKALRLFADCIREKIre----s 166  Alcanivorax sp. ...
Feature 1          # ####                                                                      
1W25_A     361 DLPCRYGGEEFVVIMPd-tALADALRIAERIRMHVSgspftva----hgremlnVTISIGVSATage----gdtPEALLK 431  Caulobacter vibr...
NP_970745  440 DSFMHVIGDEFSIFYFg--NEEEVCRFTQTLIDKINseyftw------nekkltISISVGIVNIpki----pqsSQEIIS 507  Treponema dentic...
NP_213995  710 DIIAKGDGDEFLIFAYplkKKDDVLSLIEKIRQKFSkpltid-------gkkirLSFYIGVVTYpyd----grtFSELYY 778  Aquifex aeolicus...
EDZ63478   309 SIVARMNGTEFSILLPd-cSDKEGINLAKGIYSSCKkiakgf------nldsseTFISLGLYSYnyk-----enIGQLLS 376  Campylobacterale...
EDZ62830   256 DTVAHYGNGVFAMLLKh-tDIPSALKASERLCELVSnsnffl------adreiqLKISIGITDIatl-----ytVEEIVV 323  Campylobacterale...
CAJ74182  1016 DIFIRYGNSTFALLLTn-tIMSSATNLAKRFVSTIHdypflye----evqpmgkITISLGLVEFka------qsPEEFVY 1084 Candidatus Kuene...
EDZ62594   227 DILAHWHGDKFMISFAq-iSKDELDDTAKAIRDKISkapfg---------lnghLTCSISIVEItsd-----enINTIID 291  Campylobacterale...
CAJ74890   660 DIIARYDKAEFAIIMPa-tFATRALVKADGIRQRVEytgfhdp----asgnqvnITISIGISSFpeh----aseVEPLVT 730  Candidatus Kuene...
NP_952722  227 DWLARYDDDRFVVVLPe-tDASGAMILAKRLRIRIAsmalkl------ydkeikVNAAFGVAGFtatqqkegmtPHILLD 299  Geobacter sulfur...
EDX90084   167 DLFGRFDGAQFLLVLPh-tNFDDAARMGEGLKALAGnlklsspgtaaqpeeavtVCARIGVASTens----grsLNPLLN 241  Alcanivorax sp. ...
Feature 1                        
1W25_A     432 RADEGVYQAKasgrNAVV 449  Caulobacter vibrioides
NP_970745  508 NAYDACSIAFrkggGCYE 525  Treponema denticola ATCC 35405
NP_213995  779 RAITAVKEAKrrgaGEVV 796  Aquifex aeolicus VF5
EDZ63478   377 HSDNALAQAKfsedNIYL 394  Campylobacterales bacterium GD 1
EDZ62830   324 SAMDGIEKAYsdkkIDFA 341  Campylobacterales bacterium GD 1
CAJ74182  1085 AAEFSLSAAAakgrNRVE 1102 Candidatus Kuenenia stuttgartiensis
EDZ62594   292 KLQNSIKLSKetnkGSIV 309  Campylobacterales bacterium GD 1
CAJ74890   731 LANKAFYKAKndggNRVE 748  Candidatus Kuenenia stuttgartiensis
NP_952722  300 KADRSLREALeeggEMIK 317  Geobacter sulfurreducens PCA
EDX90084   242 EADYALYQNRnegrEKTS 259  Alcanivorax sp. DG881

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