1KEH,1OQZ


Conserved Protein Domain Family
Ntn_CA

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cd01936: Ntn_CA 
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Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-aminocephalosporanic acid (7-ACA), which can be used to synthesize semi-synthetic penicillins and cephalosporins, respectively. While both PGA and CA have a conserved Ntn (N-terminal nucleophile) hydrolase fold and the structural similarity at their active sites is very high, their sequence similarity to other Ntn's is low.
Statistics
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PSSM-Id: 238911
Aligned: 34 rows
Threshold Bit Score: 452.086
Created: 21-Jun-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

cd01936 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd01936 is a member of the superfamily cl00467
Sub-family Hierarchy
cd01901Ntn_hydrolasecd01906proteasome_protease_HslVcd01911proteasome_alphacd03749proteasome_alpha_type_1cd03750proteasome_alpha_type_2cd03751proteasome_alpha_type_3cd03752proteasome_alpha_type_4cd03753proteasome_alpha_type_5cd03754proteasome_alpha_type_6cd03755proteasome_alpha_type_7cd03756proteasome_alpha_archealcd01912proteasome_betacd03757proteasome_beta_type_1cd03758proteasome_beta_type_2cd03759proteasome_beta_type_3cd03760proteasome_beta_type_4cd03761proteasome_beta_type_5cd03762proteasome_beta_type_6cd03763proteasome_beta_type_7cd03764proteasome_beta_archealcd03765proteasome_beta_bacterialcd01913protease_HslVcd01935Ntn_CGH_likecd00542Ntn_PVAcd01902Ntn_CGHcd01903Ntn_AC_NAAAcd03747Ntn_PGA_likecd01936Ntn_CAcd03748Ntn_PGA
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1KEH_A       20 ILWDGYGVPHIYGVDAPSAFYGYGWAQARSHGDNILRLYGEARGKGAEYWGPdyeqttvwlltngvpera-qqwyaqqsp 98  Brevundimonas di...
AAK23009     39 IRRDEWGVPHILGRTDADAAFGLGYAQSEDDFDTLQDVVLATRGVLARDKGAgaaptdyvvsllevwptv-dkhyaelpa 117 Caulobacter cres...
AAR37820     82 IERDPYGVPHVYGETDADAAFGLAYAQAEDAWPIMEGSLPFFRGNAGLYEGQegaqsdylvkwldlwgtldrdyervltp 161 uncultured bacte...
ZP_01101650  46 IIRDDYGVPHIYAKTDADAVFGLLYAQAEDDFPRVERNYYWAIGRLAEAEGEaalfsdlrarlymstdea-kaayakapp 124 gamma proteobact...
ZP_01108109  36 IIRDDFGVPHIYGKTDADAVFGLLYAQCEDDFNRVEQNYIWATGRLAEVEGKealysdlraklfmteeea-ktnyeespk 114 Flavobacteriales...
ZP_01223619  43 IERDIRGVPHVIGERDVDAAFGFAYAQAEDNWELVYDTIDFYRGTAAKTKGPdsaitdflvkwlgiwddidahyssglsp 122 marine gamma pro...
ZP_01104671  46 IIRDEFGVPHIYGNRDADTAFGLGYAQAEDDFATLQDVVLATRGQLAAVRGPdaaktdylirlmgvwealdsgyetvlse 125 gamma proteobact...
ZP_00522553  33 ILRDDWGIAHVHGKTDADAVFGMIYAQAEDDFNRVETNYLNSMGRLAEAEGEsriyqdlrmklfidpaal-kqqyaaspg 111 Solibacter usita...
ZP_01119049  28 IVRDAYGVPHIYAPTDAALAYGFAWAQAEDHFKLLQESYLAGNGLLGKRIGKkgagadfltqfiqskatv-nenfhtlgs 106 Polaribacter irg...
NP_419938    38 ITRDTWGIAHIHGKTDADAVFGMAYAQAEDDFNRVEANFMTSLGRTAEAEGEkaiwadlrqklfidpavl-kadyakspa 116 Caulobacter cres...
Feature 1                                                                                       
1KEH_A       99 dfranldaFAAGINAYaqqnpddispevrqvlpvsgadvvaha---------------hrlmnflyvaspgrtlgegdpp 163 Brevundimonas di...
AAK23009    118 elraimeaYADGVSLYvakhpekakpgllpvtgkdvaagfif-----------------kqpffygldgelrritapatk 180 Caulobacter cres...
AAR37820    162 eirayveaFAAGFNAFardhtdeikhpellpvtgkdivaghmlrhplf-----ygfegpvlelfgdtrpntvskaphnpk 236 uncultured bacte...
ZP_01101650 125 wlqalcdaFADGLNYYlathpevtpkvltrfepwmpmfffegsiggdieqipldgikafygegrsialaqleqareptlg 204 gamma proteobact...
ZP_01108109 115 wlkelcdaFADGINYYlhthpevkpklltrfepwmpmyfsegsiggdier-istrkiksfyesdmqipemeelklkqeke 193 Flavobacteriales...
ZP_01223619 123 eirayieaYADGLNYYaalnperavadlpvtgkdiiagymfrhilfy-------gfdgvlkevlsserqqpistangviy 195 marine gamma pro...
ZP_01104671 126 qaravaeaYADGINLYaaqhpeevedfvlpirgkdliagftfklplfygf--detltalfdgndrelalqgkdaltfvnr 203 gamma proteobact...
ZP_00522553 112 wlqelmnaFADGLNFYlathpntkprviqhfepwmalsftegsiggdie----rinlnqlqafygktpvaqlpppadpfa 187 Solibacter usita...
ZP_01119049 107 efkavlqgFTDGLNAFskkhpkeilekelfpltpqkllrytqlql-----------fisngadklvkgivndemswpydi 175 Polaribacter irg...
NP_419938   117 wlkalmnaWADGLNYYlqthptvkprviqrfepwmalsfsegsiggdi-----ervaltqleafygkrqlamtadekgll 191 Caulobacter cres...
Feature 1             #                     #                                               #   
1KEH_A      164 dladqGANSWAVAPGKTaNGNALLLQNPHLSWttdyftYYEAHLVTPD-FEIYGATQIGLPvIRFAFNQRMGITNTVNGM 242 Brevundimonas di...
AAK23009    181 gpppkGSNGLATAPSRSvDGATRLLVNSHQPYtgp-vaWYEAVVQSGQgWHVAGGFFPGSPfMLHGHNATLGWANTVSKP 259 Caulobacter cres...
AAR37820    237 pkepiGSNATAVAPSRTdDGSTYLIINSHQPLtgp-vaWYEAHLQSGEgLNIMGGLFPGAPtMGVGFTEEHGWGATVNKP 315 uncultured bacte...
ZP_01101650 205 yeqhlGSNGFAIAGEHTrSGNAMLLINPHTSLy----fRGEVHVVSEEgLNAYGAVTWGQFfVYQGFNEHTGWMHTSTGV 280 gamma proteobact...
ZP_01108109 194 mtepqGSNGIAISGELTeSGNAMLLINPHTSFy----fRGEVHVVSEEgLNAYGAVTWGQFfVYQGFNEKTGWMHTSTYT 269 Flavobacteriales...
ZP_01223619 196 nglpvGSNATAISPLNStDGATRLAINSHQPTtgp-vaWYEAHIQSGEgLNAMGGLFPGSAtIGVGFNENIAWGATVNKP 274 marine gamma pro...
ZP_01104671 204 grpalGSQGVAIAPQKSrDGKTRLLINSHQPLtgp-vaWYEARLHSEEgWNMAGATFPGSPvILHGHNRYLGWSSTVNKP 282 gamma proteobact...
ZP_00522553 188 epeptGSNGIAIAPSNTaGKHALLLINPHTSFf----fRSELQMTSDQgLNAYGAATWGQFfIYQGFNEHAGWMHTSSGV 263 Solibacter usita...
ZP_01119049 176 tqdtkGSNLLAISRSRTqSDETFLAINTHQPLegp-tsWYEAHLVSEEgTNIIGATFPGSPcLLTGANEFLGWTHTVNYP 254 Polaribacter irg...
NP_419938   192 fkeptGSNGIAIAPKLTlDGAAMLLINPHTSFf----fRSEMQVSSNEgLNAYGATTWGQFfIYQGFNAKAGWMHTSSGV 267 Caulobacter cres...
Feature 1                                                                                       
1KEH_A      243 VGATNYRLTLqd--------ggYLYDGQVRPFERRQASYrlrqadgstvdKPLEIRSSVHGPVFeradgtAVAVRVAGLD 314 Brevundimonas di...
AAK23009    260 DLVDVYRLTInpan-----knqYRLDGQWKDFDKRYVTLrvkllgpivlpVRKAVLRSAHGPVLetd-hgVFAIRYAGMG 333 Caulobacter cres...
AAR37820    316 DLVDIYVLEMnpdn-----enqYRLDGQWHDLDVSTVKLklrlwgflpwsVSREVLRSAHGPALrtd-hgVYAIRYAGID 389 uncultured bacte...
ZP_01101650 281 DFMDEFVEEIvedadgadgalmYRYGDELRPVEVSEVTLrykta-dgmaeRTFPRYRTHHGPIThml-dgQWVATRINWD 358 gamma proteobact...
ZP_01108109 270 DVMDEFRETIvkmd----ekllYQYGEELRPIETSEITLkykds-dvlkeKIYPAYHTHHGPIThmv-ngNWTASAMMWE 343 Flavobacteriales...
ZP_01223619 275 DLVDVYVLDIdped-----plrYRIDGEWRDLEVTELSVdvklwgflpwtTSELGLRSIHGPVLqtd-hgTYAIRYAGMG 348 marine gamma pro...
ZP_01104671 283 DLVDVYQLTLnpen-----edeYLLDGEWVALEKRSADIlvrlfgpfrwtFSEPLYASRHGPVLkld-hgTFAIRWSGMG 356 gamma proteobact...
ZP_00522553 264 DAVDEYLETVtksg----dgytYKFGAEQRPVTASEIVVpyrtp-qgmaeKKFTVYRTQHGPIVrel-ngKWVAIRLMQE 337 Solibacter usita...
ZP_01119049 255 DKADVFALEMhpek-----kdvYLVDGAEYKLEKLKAKLnlkfl-glnipIKKKFYKSMYGPTLknk-tgVYSVRTPSTT 327 Polaribacter irg...
NP_419938   268 DVVDEFIETIvekd----gqrfYKYGDQLRPLKTEVITApyrtadgamaeRKFTVFKTHRGPIVree-ngKWISIALMNK 342 Caulobacter cres...
Feature 1                                                                                       
1KEH_A      315 RpGMLEQYFDMITAHSFDDYEAAMARMQvpTFNIVYADREGTINYSFNGVAPKRAegdiafWQGNVP--GDSSRYLWTET 392 Brevundimonas di...
AAK23009    334 EwRQPLQYWRLNRARTVEDWRAAIATHAipSLNYVYADAAGNIGFVHNGQYPNRRak--adWGGVLP--GDRSDLIWQGY 409 Caulobacter cres...
AAR37820    390 EmKQVEQWLAMNKAKNFEQWRAAVALNHiqSFNFVYANRHGDIHFIHNAQLPIRApg--wdWQQYLP--GDRSDLIWNAY 465 uncultured bacte...
ZP_01101650 359 PvTALEQSYVRSKKSGLEGFNEMMDLRTnsSNNTVYADSSGNIAYYHGNFIPRRNt----qFDFSRPvdGSNPATDWQGL 434 gamma proteobact...
ZP_01108109 344 PvKALEQSFVRTKKNGYKGFREMMDIRTnsSNNTVYADAEGNIAYFHGNFVPKRDt----qFDYSESvdGSNPKTDWQGL 419 Flavobacteriales...
ZP_01223619 349 KmRQVEQWLAMNKAQNLEQWRDALRIHSfaSFNFVYADRDSNIMFVHNSLTPVRVgg--ydWSQYLP--GDDSSLIWQDY 424 marine gamma pro...
ZP_01104671 357 EiRTLDQYLALNKATSMAEFEAALAIGSqpSINQVYADREGNIAHYYNAMLPKRQeg--wdWTKDLP--GDDSSLIWTNY 432 gamma proteobact...
ZP_00522553 338 PiKALTQSYTRTKATNYKAYLETMELKAnsSNNTIYADDSGTIAYFHGNYIPRRDt----sFDWTKPvdGSNPATEYKGL 413 Solibacter usita...
ZP_01119049 328 NiNAIEQWWHMNKAKSFTEFYTALKMKAlpGYNIGYADRNDTIFYISNGKIPIRAkg--ydWTDVVP--GNTRKTLWDSY 403 Polaribacter irg...
NP_419938   343 PvAALQQSFLRTKATDYAAFMKVAELKAnsSNNTLFASAKGEIAYLHPQFIPIRDd----rFDYTKPvdGADPATDWKGL 418 Caulobacter cres...
Feature 1                           #                                                           
1KEH_A      393 HPLDDLPRVTnppgGFVQNSNDPPWtp-twPVTYCPAnhpsylapqtphsLRAQQSVRLMSENd------dLTLERFMAL 465 Brevundimonas di...
AAK23009    410 LPVENSPQLWnpksGLVFNSNNTPFeaseaADNLKPAdfpas---mglqaNMTNRAWRALETYgad---raLTDASFRAH 483 Caulobacter cres...
AAR37820    466 YPTNALPQVTnprsGFIHSANQTPFnvtsaADNPTKTdapad---ggwqtRMTNRATRGLELFekf---gqISDEEAWEL 539 uncultured bacte...
ZP_01101650 435 HTVDEIVTVInpenGWLQNCNSTPFta-agAFSPRREdyp-------vymAPDKENFRGIHAQqvlegvsdLTLEGLLDL 506 gamma proteobact...
ZP_01108109 420 HTVDENILLLnpenGWLQNCNSTPYta-alEFSPKKEnyp-------nymSIDRENFRGIHAIdllkdrkgYTLDNLIEL 491 Flavobacteriales...
ZP_01223619 425 MAFDKLPQVInpesGFIHSANQSPFfvtatGSNPKIAdyrpe---dgfptRMTNRAVRGLEMFael---spISEDEFSQI 498 marine gamma pro...
ZP_01104671 433 LPFSAVPATRnppsGFVFNANNSPYlssigPGQPQPEdfsdt---mgietGVTNRALRLRRLLqetetlsrEDFYRIKYD 509 gamma proteobact...
ZP_00522553 414 LEVNEAPNLLnpkvGWLYNTNNWPWsa-agPDSLKKEnfp-------ayvESGGESARGLHAIrvlqnrkdFTLDSLIAA 485 Solibacter usita...
ZP_01119049 404 YDIQDLPQVIspksGFVYNANHSPFkssgaADNPKAEnfara---mqyetYDNNRSTRLLQLLeaq---ehIDYKRFKRI 477 Polaribacter irg...
NP_419938   419 HALKDAPHVLnppnGWTFNTNNWPYta-agPYSPKLAdfpky----mdtfGENPRGLHAELVLkdv---knLTLGGLIEK 490 Caulobacter cres...
Feature 1                                                                                       
1KEH_A      466 QFSHRAVMADRTLPDLipaal-----idpdPEVQAAARLLAAWDRDFTSDSRAALLFEEWarlfagqnfagqaafatpws 540 Brevundimonas di...
AAK23009    484 KFDVAFSDRSSVMAMVgevlav---dpkgdADLAEAQRILRAWDKRADRTNRGAALAALMsqpilfantngdpapapids 560 Caulobacter cres...
AAR37820    540 KHDNDYSPNYRGMAFFkrvtg----lsattETQAQAIAVLKAWDRSTDKANRGAALGVCVlaaewqaesggnnnpepadv 615 uncultured bacte...
ZP_01101650 507 AYDNYLPGFEVLISGLieayda---ggdpyPELAAPIAALRDWDRRTREDSVAMSLAQFYgmqyredganprglrrmali 583 gamma proteobact...
ZP_01108109 492 AHDPYLPAFEKLIPGLikaydt---hddknPKLREAIDVLREWDFKTSKESAAMTLAHFYgtkyyaegeyekgltpmerv 568 Flavobacteriales...
ZP_01223619 499 KHDKKYSPNSRAVRFLqgainlp-ladsaqQSYIDAQAVIRDWDLSTDIENRGAAISTCVigvewlaeqkgeptpdvada 577 marine gamma pro...
ZP_01104671 510 VFYDEDLEAIQQLRRFiangk-----dalpPSLHAAMDLLASWDLGTQADNPAAALGVLTlttlidsrqrrddvelgeel 584 gamma proteobact...
ZP_00522553 486 AYDSYLPWFEKPMPALikawdeatatdplkSKLAAQIELLRKWDYRWNVNSVATSLAVFWaedlrrrvgaggrggrgdda 565 Solibacter usita...
ZP_01119049 478 KYDHQLPTPLQYNYMDlnalfe--meidnyPAVDVLLSDIKNWDRITDPVSYGAGAYAVLyyqlmphylkldanhifska 555 Polaribacter irg...
NP_419938   491 AYDPYLTAFARLIPTLetayaatsdsdpikAKVAAQVAALAAWDRKWSTRSTETSLAVFWgetmwakaapaakaqglnty 570 Caulobacter cres...
Feature 1                                                                                       
1KEH_A      541 ldkpvstpygvrdpkaavdqlrtaiantkrk------ygaidrpfgdasrmilndvnvpgaagygnlgsfrvftwsdpde 614 Brevundimonas di...
AAK23009    561 lraaiktlkthfgrldpew------------------------------gevnrirrgtvdlpidgaadtfrsvwgkpqk 610 Caulobacter cres...
AAR37820    616 lddcidqtleiggqldpewg-----------------------------evnrhgrggtlwpvaggpdtlraiysrrldg 666 uncultured bacte...
ZP_01101650 584 nyfgqesplderlrvfasavkrlendfgqwntpw-geinrfqrlsgdinlsfdddkpslpvglasgdwgalasyravgrn 662 gamma proteobact...
ZP_01108109 569 tfwgsespnseklrifetvvdqlnedvgswnttwgevnryqrlngdirqafddskpsipvgfasgrwgalaaygarytnn 648 Flavobacteriales...
ZP_01223619 578 fyscadrlmaatgridplwg-----------------------------dvnrhvrgdlnlpvgggpdtlraiyalgmee 628 marine gamma pro...
ZP_01104671 585 aeardylqshfgridppyg------------------------------evvrhvrgdqswpldggpdtlravytekdpe 634 gamma proteobact...
ZP_00522553 566 iatappaqllqsldaasekiaadfggwqtkwgd---inryqrltgdivqpfndagpsipvgftssqwgslasfgaraypg 642 Solibacter usita...
ZP_01119049 556 ilyealkdtkgylkkyfnseri-------------------------qlgafqklvrgdksipifglpdvvtamrgvpdk 610 Polaribacter irg...
NP_419938   571 dymadklsaadklaalaeasdrltadfgswktpwgeinrfqrndgaivqtfddtkpslpvgftsaqwgslasfgakrwpg 650 Caulobacter cres...
Feature 1                                                                    
1KEH_A      615 ngirtpvhGETWVAMIEFst--pVRAYGLMSYGNSR-QPGTTHYSDQIERVSRADFRELLL 672 Brevundimonas diminuta
AAK23009    611 dgtttadgGDTFVMFVTWdkagaLRSESIHQFGSATlDAASPHYADQTPLFVAMKTKPVRF 671 Caulobacter crescentus CB15
AAR37820    667 ddyltavaGDGLYYIIRWmpsgeRRVLGTHQYGNDMtNADSPHYLDQAEDYANEVLHEPLY 727 uncultured bacterium 443
ZP_01101650 663 tkrlygvsGNSFVAVVEFgd--rVRAKSILAGGQSG-DPESPHFYDQAQPYIDREFKDVAF 720 gamma proteobacterium KT 71
ZP_01108109 649 tkkiygtrGNSFVAVVEFge--kVKAKSMLAGGQSG-DPNSLHFNDQAQPYADMQFKDVPF 706 Flavobacteriales bacterium HTCC2170
ZP_01223619 629 dgyqtniaGDGLYYFVSWdaqgvQKIRGVHQFGAATlDTQSPHYADQAKDYTAEILHDPLF 689 marine gamma proteobacterium HTCC2207
ZP_01104671 635 tgilrnvaGDSYIMFVEWdqkgqVSSRAIHNFGSATlDASSPHYGDQAPLFVKHQDKPVRL 695 gamma proteobacterium KT 71
ZP_00522553 643 tkkwygtsGNSFVAVVEFgk--tVRARAVTAGGESG-DPKSPHFNDQAARYSTGTLREVYF 700 Solibacter usitatus Ellin6076
ZP_01119049 611 ngrikithGESYIGLVRFtp-tkTYYESVISFGNSR-RPESSHYTDQMELYAKFKTKTMSF 669 Polaribacter irgensii 23-P
NP_419938   651 tkkyygtlGNSFVAVVQFgd--kVRARAISAGGESG-DPASPHFNDQAPRYAIGNLRDVYF 708 Caulobacter crescentus CB15

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