2BJG,3PVA


Conserved Protein Domain Family
Ntn_CGH_like

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cd01935: Ntn_CGH_like 
Click on image for an interactive view with Cn3D
Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which cleave non-peptide carbon-nitrogen bonds in bile salt constituents. These enzymes have an N-terminal nucleophilic cysteine, as do other members of the Ntn hydrolase family to which they belong. This nucleophilic cysteine is exposed by post-translational prossessing of the precursor protein.
Statistics
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PSSM-Id: 238910
Aligned: 97 rows
Threshold Bit Score: 97.0408
Created: 25-Apr-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #                 # #                                                #          
2BJG_B        2 CTGLALEtkd--glHLFGRNMDIeys-fnQSIIFIprnfkcvnksnkkelttkyavlgmgtifddyPTFADGMNEKGLGC 78  Clostridium perf...
NP_691778    98 CSVFTSS-------NYMIRNYDYhpktyeGRLVLFqptdtglt---------------tigpsqriTGRLDGMNQYGLVL 155 Oceanobacillus i...
NP_691962    98 CSIYTEA-------DFLIRNYDNaprsyeGRYVIYkptdagya---------------tvgptmqiTGRTDGINEKGFAM 155 Oceanobacillus i...
NP_765171    99 CTVYKGR-------DFLVRNYDYhpatydGRYLLFqpndggls---------------qigptsrvTGRMDGMNEYGLVM 156 Staphylococcus e...
CAG70012     92 CSQGVWFdpkgqeePILLRNYDFapvlleGNLLNTrwldqrv-----------------iamsdclWGALDGVNEAGLSA 154 Acinetobacter sp...
ZP_00537897  98 CSIMTGD-------NFLVRNYDYhpmtydGRFSVFqptdggsa---------------iigpasrvTGRMDGMNEHGLAM 155 Exiguobacterium ...
ZP_00948945  88 CSQAVWGgk----ePVMVRNYDYntnafdSLVLHTgwkgrrv-----------------mgtsdglFGLVDGVNDAGLSI 146 Sulfitobacter sp...
ZP_00963591  92 CSLAVATsd---ddIRLVRNYDLspdlneGLLLHSawtgrrv-----------------mgmveflWGLSDGINDAGLSI 151 Sulfitobacter sp...
ZP_01172832 102 CTAVMTK-------DFYVRNYDFspefydGIFTLSenlpalas----------------agynlqaIGRHDGVNEKGLAA 158 Bacillus sp. NRR...
ZP_01173760  98 CSILTGS-------SYLIRNYDYhpktyeGRYTLFqptdqgya---------------iigpsqrvTGRMDGMNEKGLVV 155 Bacillus sp. NRR...
Feature 1                                                                      #                
2BJG_B       79 AGLNFpvyvsyskediegktnipvYNFLLWVLANFSSVEEVKEALKNANivdipisenipNTTLHWMISDItgKSIVVEQ 158 Clostridium perf...
NP_691778   156 GYNFThrkqpg--------egficNMISRIVLETCSSVEEAVHLLQEIPh----------RYAFSYLVLDQheETFIIEG 217 Oceanobacillus i...
NP_691962   156 GYNFVnriksd--------dgfvcNMIGRLLLENCASVEEAKQLLQELPh----------RHTFSYVLLDKngYSVVAEV 217 Oceanobacillus i...
NP_765171   157 AYNFMhrkkpa--------ngfvcYMVGRLILENCKNVTEAIKFLKEVPh----------RSSFSYILMDRhsNYAIVEV 218 Staphylococcus e...
CAG70012    155 SLSFGgrtvtg--------tgfgiPLVLRYILELAHTTQDAVNILKRIPv----------HMTYSVTLLDRkgEWNTVFV 216 Acinetobacter sp...
ZP_00537897 156 GYNFInrrrpg--------dgfvsFMIGRIILETCTSVEDAISLVKEMPh----------RGSFSYVVHDRsnRSFVIEA 217 Exiguobacterium ...
ZP_00948945 147 SLTFGgrrvvg--------vgfgvPLILRYVLQTCETAEQAGEILARVPt----------HMSYNVTVLDRkrKYLTALM 208 Sulfitobacter sp...
ZP_00963591 152 ALAYGgrqetg--------rgfgiTTILRYVLETCETVPQALRVLQRVPs----------HMPYNVVVADAsgAGASVEM 213 Sulfitobacter sp...
ZP_01172832 159 GLHFVshdgyq--------eglsaWTSVRMVLDTCATVREAAELLKEIPh----------AACYNFSLADSfgNQGAVEA 220 Bacillus sp. NRR...
ZP_01173760 156 GYNFMnrkkpg--------dgficCMIGRLLLESCADADEAVSMLKEIPh----------RHSFTYVVYDRsgKSFAVET 217 Bacillus sp. NRR...
Feature 1                                                                                       
2BJG_B      159 tKEKLNVFDnn--iGVLTNSPTFDWHVanlnqyvglrynqvpefklgdqsltalgqgtglvglpgdftpASRFIRVAFLR 236 Clostridium perf...
NP_691778   218 sARGTSVRKg----NLCTNHFENLTAEnrny----------------------------------lddsYRRLLAMQNNS 259 Oceanobacillus i...
NP_691962   218 sPRNVKFREa----NMCTNHFEELTEEnryr----------------------------------tdesMERLNKISSQQ 259 Oceanobacillus i...
NP_765171   219 tPRSIDVRYe----HICTNHFELLTHEnrny----------------------------------tresKERLNRVINKT 260 Staphylococcus e...
CAG70012    217 sPDRQPEVVk---rHAVTNYQNAIEWPqhat----------------------------------athsAERLTFLEQVL 259 Acinetobacter sp...
ZP_00537897 218 tARDIEVREt----NLCTNHFDLLQHEnrfh----------------------------------lddsKRRMMELKTHQ 259 Exiguobacterium ...
ZP_00948945 209 aPDRPAIITk---aAVATNHQENVEWIsharf--------------------------------tatveRERYLLQRLRF 253 Sulfitobacter sp...
ZP_00963591 214 yAGGGAKVQp---rLVATNHQTDGSTPdrgs----------------------------------ftrtFERSKHLVSVL 256 Sulfitobacter sp...
ZP_01172832 221 sPDKVLIRQgpeefHSCVNHFRSEEMAgknre--------------------------------hidgsIKRTGYLDLVG 268 Bacillus sp. NRR...
ZP_01173760 218 sPRRVEIRQt----NACTNHFEIMKDEnrhh----------------------------------ladsLRRLAVIKETG 259 Bacillus sp. NRR...
Feature 1                                                                  
2BJG_B      237 DAMIKNdk------------dsIDLIEFFHILNNVAMVRGstrtveeksdltqYTSCMC 283 Clostridium perfringens
NP_691778   260 AKKLSAeeafrmmndtdrgvfsKQYKNWGGTIHTSGYLPAer----------kVWFSLG 308 Oceanobacillus iheyensis HTE831
NP_691962   260 SSVENPyeayqllnnlekgvfsKKYDAWAGTLHTAAYLPKem----------kAWIALG 308 Oceanobacillus iheyensis HTE831
NP_765171   261 TPSTNKdiafklfndpqyeiysNLFKSWSGTIHTSLYEPNsl----------iAWMALG 309 Staphylococcus epidermidis ATCC 12228
CAG70012    260 HHATNShevlqgl--ltkplyqDAWLRGYGTLYSAIYRPLsq----------kVEICWP 306 Acinetobacter sp. ADP1
ZP_00537897 260 HLIQDAesafrllndsdkgvfsELYSHWAGTIHTSAYFPTdm----------kVWFALG 308 Exiguobacterium sibiricum 255-15
ZP_00948945 254 HRDPEEkfintfl---kpplysHQFNAGFGTLYTAVYRPRkr----------eMEHRWP 299 Sulfitobacter sp. NAS-14.1
ZP_00963591 257 SEGLTPsalagqf--tqaplkqERYAEGFGTLFTAEYEPKrr----------kMTLHWD 303 Sulfitobacter sp. NAS-14.1
ZP_01172832 269 SKQLSFqqtfdllrdsesplffTDYEDLFGTLHTFGYSFQds----------qIVTSLC 317 Bacillus sp. NRRL B-14911
ZP_01173760 260 VEMTEAmeafrllndtdkgvfsDLYSSWAGTIHTSGYLPQeg----------kAWFALG 308 Bacillus sp. NRRL B-14911

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