Conserved Protein Domain Family
cyclophilin_CeCYP16-like

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cd01925: cyclophilin_CeCYP16-like 
cyclophilin_CeCYP16-like: cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced peptidylprolyl cis- trans isomerase activity, is cyclosporin insensitive and shows an altered substrate preference favoring, hydrophobic, acidic or amide amino acids. Most members of this subfamily have a glutamate residue in the active site at the position equivalent to a tryptophan (W121 in Human cyclophilin A), which has been shown to be important for cyclophilin binding.
Statistics
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PSSM-Id: 238906
Aligned: 14 rows
Threshold Bit Score: 290.408
Created: 13-Oct-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:Based on similarity to related proteins with known structure and function.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                    ##    #                          
AAM19304    8 EPITTGKVTLETTAGDIEIELWTKEAPLACRNFIQLCMENYYKGTVFHRLVKNFILQGGDPTATGTGGESIYg------- 80  nematode
AAL48610    8 EPPTSGKVLLKTTVGDIDIELWARECPKACRNFVQLCLEGYYKNTEFHRLVKGFIVQGGDPNGDGTGGESIYg------- 80  fruit fly
O42941      8 EPLATGTVILKTTRGDIQIELWCKEVPKACRNFIQLCLEGYYDGTIVHRVVPEFLIQGGDPTGTGMGGESIYg------- 80  fission yeast
CAB80023    8 EPPTKGKVIVNTTHGPIDVELWPKEAPKSVRNFVQLCLEGYFDNTIFHRVIPGFLVQGGDPTGSGTGGDSIYg------- 80  thale cress
NP_702112   8 EPKTHGKVIIYTSLGELEIHLFSNECPEACRNFIQHCLNNYYNKNEFFRVIPRFLIQTGDHTNTGLHNEYAFs------- 80  Plasmodium falcipa...
NP_957397   8 EPPTNGKVLLKTSAGDIDIELWSKETPKACRNFVQLCMEGYYDGTIFHRMVPEFIVQGGDPTGTGTGGESIYg------- 80  zebrafish
EAK85086    8 EPPSSGLVDLVTSKGTISIALFPTQAPLACRNFLTLALEGFYDNLVFHRLIPNFILQTGDPSATGTGGESIYg------- 80  Ustilago maydis 521
AAH74317    8 EPPSNGKVLLKTTAGEIDIELWSKEAPKACRNFVQLCLEGYYDNTIFHRVVPEFIIQGGDPTGTGTGGESVFg------- 80  African clawed frog
XP_463359   8 EPPTKGKVVVQTTAGPLDIELWPKEAPKAVRNFVQLCLEGYYDGTLFHRVIKSFLVQGGDPTGSGTGGESIYg------- 80  Japanese rice
CAE75687    8 EPQPTASAIIHTTQGEIAVELFAKQTPLTCRNFLQLALDGYYDNTIFHRLIPGFIVQGGDPSGTGHGGESIYdngalsgd 87  Neurospora crassa
Feature 1                                                        # #         #                
AAM19304   81 ------------------kPFKDEIHQRLKFNRRGIVGMANAGrd--dNGSQFFFTIGdrGAPELDKKHTIFGKVTGPTL 140 nematode
AAL48610   81 ------------------qPFKDEFHSRLRYTRRGLVGMANSGkd--dNGSQFFFTFA--PTPELQNKNTLFGKITGDTI 138 fruit fly
O42941     81 ------------------ePFAVETHPRLRFIRRGLVGMACTEne--gNNSQFFITLG--PTPEWNGKQTLFGRVVGDTI 138 fission yeast
CAB80023   81 ------------------gVFADEFHSRLRFSHRGIVAMANASsp-nsNGSQFFFTLD--KCDWLDKKHTIFGKVTGDSI 139 thale cress
NP_702112  81 ------------------sPFKNEYNSRLKFLYTGCLSFANLNidkpsNGSQFFITLD--KAEYLNNKNTLFGKVAKHSI 140 Plasmodium falcipa...
NP_957397  81 ------------------rPFKDEFHSRLRFNRRGLVAMANAGph--dNGSQFFFTLG--RADELNNKHTIFGKVTGDTV 138 zebrafish
EAK85086   81 ------------------ePFPIESHSRLKFNRRGLLGMAANQdr--tNESQFFLTLD--ATPELTGKHTLMGKVEGKSI 138 Ustilago maydis 521
AAH74317   81 ------------------kPFRDEFHSRLRFNRRGLVAMANAGph--dNGSQFFFTLG--RADELNNKHTIFGKVTGDTI 138 African clawed frog
XP_463359  81 ------------------aPFADEFHTRLRFNHRGLVACANAGtp-hsNGSQFFISLD--RCDWLDKKNTIFGKVTGDSI 139 Japanese rice
CAE75687   88 ldpwpmdqrrgknagphgvNFKDEFHSRLKFNRRGLLGMANEGap-dtNSSQFFFTLG--KADELTGKNTMFGRVAGDTI 164 Neurospora crassa
Feature 1                                              
AAM19304  141 FNMLKItevetegdrp--vtfykitgaRIDNNPFDDLKPRE 179 nematode
AAL48610  139 YNMLKLedgivdhqer-pmhahrivstEVLSNPFDDIVPRI 178 fruit fly
O42941    139 YNVVRIseleldanqr-pvfppkiistEVIDNYFTDIKPRS 178 fission yeast
CAB80023  140 YNLLRLgevdtskddrpldpapkilsvEVLWNPFEDIVPRV 180 thale cress
NP_702112 141 YNLLKFnniktnkhdkpiedipyieyvKIIENPFHHLVPSI 181 Plasmodium falciparum 3D7
NP_957397 139 YNMLRLadvacdgder-plnphkirstEVLHSPFDDIIPRE 178 zebrafish
EAK85086  139 YTLVELvegvelvdgdrprypiklhevRVVENPFDDLQPRT 179 Ustilago maydis 521
AAH74317  139 YNILRLaevdigeder-pvnphkikctEVLFNPFDDIIPRI 178 African clawed frog
XP_463359 140 FNLLALadietdkddr-pvypqkilsvEVLWNPFDDIVPRQ 179 Japanese rice
CAE75687  165 YNLAKIgeaeveeggerplypikitriEILINPFDDMQKRE 205 Neurospora crassa

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