Conserved Protein Domain Family
cyclophilin_RING
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cd01923: cyclophilin_RING 
cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human cyclophilin A exhibit reduced peptidylprolyl cis- trans isomerase activity and lack a residue important for cyclophilin binding. Human hCyP-60 has been shown to physically interact with the proteinase inhibitor peptide eglin c and; C. elegans MOG-6 to physically interact with MEP-1, a nuclear zinc finger protein. MOG-6 has been shown to function in germline sex determination.
Links
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Statistics
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PSSM-Id: 238904
Aligned: 11 rows
Threshold Bit Score: 271.211
Created: 5-Oct-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:Based on similarity to related proteins with known structure and function.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                  ##    #                            
AAL28843  281 YVRLNTNl----GPLNLELFCDQTPRACDNFIKHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFkp 356 fruit fly
Q13356    281 YVRLHTNk----GDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFrp 356 human
CAG32120  281 YVRLHTNk----GDLNLELHCDMTPRTCENFIKLCKKNYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFkp 356 chicken
AAH44993  281 YVRLHTNk----GDLNLELYCDKTPKTCENFIKLCKKNYYDGTIFHRSIRNFVIQGGDPTGTGTGGESFWGKPFKDEIkp 356 African clawed frog
EAK86138  294 YVRLSTNf----GALNLELHCGKAPKTCFNFLQLCKHGKYDDTLFHRNIPGFMIQGGDPTGTGRGGSSIWNSNFRDEFne 369 Ustilago maydis 521
AAH71410  281 YVRLHTNk----GDLNVELHCDKVPKAGENFIKLCKKGYYDGTVFHRSIRNFMIQGGDPTGTGTGGESFWGKPFKDEFrp 356 zebrafish
AAM13295  345 YVQFQTTh----GDLNIELHCDIAPRACENFITLCERGYYNGVAFHRSIRNFMIQGGDPTGTGKGGESIWGKPFKDEPns 420 thale cress
P52012    281 FVRLVTNf----GPLNLELFAPKVPKACENFITHCSNGYYNNTKFHRLIKNFMLQGGDPTGTGHGGESIWDKPFSDEFis 356 nematode
Q09928    232 YARIVTNh----GEINIELHTDYAPHAVYNFVQLAKQGYYRNTIFHRNIARFMIQGGDPSGTGRGGQSIWGKPFKDEFcn 307 fission yeast
XP_322267 331 YVRMETNl----GPLTLELLPEFAPKAVWNFLRLSEKGYYRDVAFHRSIRNFMIQGGDPSGTGRGGSSIWGKNFEDEFeg 406 Neurospora crassa
CAG78939  244 YALLTINcqgkrGQINLELYPYNAPLTVYNFVKLAQKGYYDGTIFHRNIKHFMIQGGDPTGTGSGGESIFGKTFRDECgt 323 Yarrowia lipolytic...

Feature 1                             # #       #                                             
AAL28843  357 nl--thtGRGVLSMANSGPNTNGSQFFITyrSCKHLDGKHTIFGKLVGG-----LDTLQKMenie-vdnkDRPIEDIIIE 428 fruit fly
Q13356    357 nl--shtGRGILSMANSGPNSNRSQFFITfrSCAYLDKKHTIFGRVVGG-----FDVLTAMenvesdpktDRPKEEIRID 429 human
CAG32120  357 nl--shtGRGILSMANSGPNTNKSQFFITfrSCAYLDKKHTVFGRVVGG-----FETLTAMenvesdpktDRPKEEIRIQ 429 chicken
AAH44993  357 nl--shtGRGVLSMANTGPNTNKSQFFITfrSCTYLDKKHTVFGRVVGG-----FDTVSAMekvdtdhktDRPKEEIRIE 429 African clawed frog
EAK86138  370 pgafkhdTRGVLSMANKGKDTNASQFFITyrGVPHLDGKHTVFGRLVDGd---kDATLTKMeqvpseqgtDRPLKKIQIQ 446 Ustilago maydis 521
AAH71410  357 nl--shtGRGILSMANSGPNTNKSQFFITfrSCAYLDRKHSVFGRVVGG-----LETLSAMenvesdpktDKPKSEIKIL 429 zebrafish
AAM13295  421 kl--lhsGRGVVSMANSGPHTNGSQFFVLykSATHLNYKHTVFGGVVGG-----LATLAAMenvp-vdesDRPLEEIKII 492 thale cress
P52012    357 gf--shdARGVLSMANKGSNTNGSQFFITfrPCKYLDRKHTIFGRLVGGqd--tLTTIEKLete---egtDVPMVSVVIM 429 nematode
Q09928    308 pl--khdDRGIISMANRGKNTNGSQFFILygPAKHLDNKHTIFGRVVGG-----LNVLDALekvp-tnsnDHPKLPIKLE 379 fission yeast
XP_322267 407 pn--thsARGIVSMANKGKNTNSSQFFITyrPASHLDRKHTIFAKVIEGqd-ttLTAMENVatd----gsDRPLNKIVIK 479 Neurospora crassa
CAG78939  324 fnphthdSRGVLSMANRGKGTNSSQFFITysRAPHLDGKHTVFGRVVDNsflttLELSETVd--------DKPVKNITLE 395 Yarrowia lipolytic...

Feature 1                
AAL28843  429 SSQVFVNPFAE 439 fruit fly
Q13356    430 ATTVFVDPYEE 440 human
CAG32120  430 ATTVFVDPYEE 440 chicken
AAH44993  430 CTTVFVDPYEE 440 African clawed frog
EAK86138  447 DVLVTEDPFEQ 457 Ustilago maydis 521
AAH71410  430 STSVFVDPYEE 440 zebrafish
AAM13295  493 EASVFVNPYTE 503 thale cress
P52012    430 RAEVFVDPFEE 440 nematode
Q09928    380 DIIIFVDPFEE 390 fission yeast
XP_322267 480 DMIILIDPFAE 490 Neurospora crassa
CAG78939  396 SVSVSSDPFSF 406 Yarrowia lipolytica CLIB99

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