Conserved Protein Domain Family
cyclophilin_RRM
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cd01921: cyclophilin_RRM 
cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain including the nuclear proteins: human hCyP-57, Arabidopsis thaliana AtCYP59, Caenorhabditis elegans CeCyP-44 and Paramecium tetrurelia Kin241. The Kin241 protein has been shown to have a role in cell morphogenesis.
Links
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Statistics
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PSSM-Id: 238902
Aligned: 13 rows
Threshold Bit Score: 214.512
Created: 5-Oct-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:Based on similarity to related proteins with known structure and function.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                               ##    #                                  
AAH56814       4 LLETTLGDIVIDLyteeRPKASLNFLKLCKIKYYNYCLIHNVQRDFIIQTGDPTGtgrggesvf-------------ckl 70  zebrafish
XP_459815      4 LLETTEGNIVIDLfidqQPLACYNFLKLCKLNYYFFTPFYNLHKDLIVSSGDPDYpentdgdainsfgdvnvnnttvkqn 83  Debaryomyces ha...
EAL23123       1 MLETSLGDLIIDLevdkCPRTCENFIKLCKLKYYALNAFFNVSKNFIAQSGDPTAtgtggeslasyv-------ysqsps 73  Cryptococcus ne...
bzub:AFR649W   4 LLETTIGDLVVDLdyktCSAESYNFLKLCKTRFYDCQCIYDLHPEGSARLGDPQVgfafrtdlpvh---------ntsie 74  Eremothecium go...
NP_595894      4 LIETTVGDLVIDLfvkeAPKTCENFLKLCKLKYYNFCPFYNIQHNYTCQTGDPLGptgdggrcv-------------wnv 70  fission yeast
NP_492343      4 LIETTLGDLIIDLfvkeRPRCSLNFLKLCKKKYYNLNQFHSIERNYVAQTGDPTGtgkggesvy-------------sdm 70  nematode
BAD45991       4 LIVTSVGDIEVDLhtdmCPLTTKNFLKLCKMKYYNGCLFHKVEKDFLAQTGDPTGtgaggdsvy-------------kfl 70  Japanese rice
AAS75309       4 LIVTSLGDIVIDLhsdkCPLTCKNFLKLCKIKYYNGCLFHTVQKDFTAQTGDPTGtgaggdsiy-------------kfl 70  thale cress
NP_651291      4 VIETTMGDLTVDLfiseRPIACLNFLKLCRLKYYNFNLFHTVQQGFIAQTGDPSGagdggssiw-------------gvv 70  fruit fly
XP_327465      4 LLETSAGDIVIDLlvdyAPKMCENFLKLCKVKYYNFSPIHSIQKSFSFQTGDPLGplssesdggqsiwg----llsgdps 79  Neurospora crassa
NP_624311      4 LLETTLGDVVIDLyteeRPRACLNFLKLCKIKYYNYCLIHNVQRDFIIQTGDPTGtgrggesif-------------gql 70  human
XP_419663      4 LLETTLGDLVIDLyteeRPRACLNFLKLCKIKYYNYCLIYNVQRDFIIQTGDPMGtgrggesif-------------ckl 70  chicken
CAC35733       4 VLETSLGDIIIDLht-qVSLAAKNFIKLCKSKFYNGALIYNVQKDYLASIKSVNPattv--------------------- 61  Paramecium tetr...

Feature 1                                                   # #        #                         
AAH56814      71 ygdqarFFESEkmprikhrkkgTVSMVNNGsdq-------hgsQFLITtgenVDYLDGVHt---VFGEVte-gMDVLAKI 139 zebrafish
XP_459815     84 kylpvpNSQHEyvdn----sigLVSFVTKKdtngkd--lvigsQFTISltenTENLKSFSq--vYFGKVve-gFQVLEKI 154 Debaryomyces ha...
EAL23123      74 gprpprYFTPEilnslkhthkgTLSMAVAPinpp-----gcgsQFFITladnIDYLDGKHa---VFGHVie-gLDTLDKI 144 Cryptococcus ne...
bzub:AFR649W  75 glrdtrAVTPKlieasvaaqpaERFGQVAFvlkpg----trllGSNILl--aLNPEPRPHintvRFAQVidesLAVLQQL 148 Eremothecium go...
NP_595894     71 lnkgtrFFKAEfnpslvhnkmgLVSMSTATissrddkllvcgsQFIITl---SDNLEGLDerypIYGQVae-gFDTLLKI 146 fission yeast
NP_492343     71 ygeqgrYFEREdlpkmrhtrmgIVSFVNNGdnm-------lgsQFFITlgenLDYLDDQHt---IFGQVte-gLETLEKL 139 nematode
BAD45991      71 ygdqarFFDDEirpdlrhskkgTIAMASAGenc-------nasQFYITlrddVDYLDDKHt---VFGMVae-gFDTLTKI 139 Japanese rice
AAS75309      71 ygeqarFYKDEihldlkhsktgTVAMASGGenl-------nasQFYFTlrddLDYLDGKHt---VFGQIae-gFDTLTRI 139 thale cress
NP_651291     71 egpqkrFFEAEflpkinhssagMLSLVSAGknl-------vgsQFFLTlgenLTSLDGNHc---VIGEVve-gHEVLRKL 139 fruit fly
XP_327465     80 ektfpaLFHPKlkhl----ergTVSMATVPhpsdpd-trlagsQFIVTlgdnTDYLDGKAa---IFGKVve-gFDVLEKI 150 Neurospora crassa
NP_624311     71 ygdqasFFEAEkvprikhkkkgTVSMVNNGsdq-------hgsQFLITtgenLDYLDGVHt---VFGEVte-gMDIIKKI 139 human
XP_419663     71 ygdqarFFEAEkvprikhkkkgTVSMVNNGsdl-------hgsQFLITtgenLDYLDGVHt---VFGEVte-gMDVLKTI 139 chicken
CAC35733      62 --ynqpYFEDQinpllrhnqygVVATSNSKpha-------nnsDFYILltqnAPQLDGKHt---IFGQVqe-gFEVLQQI 128 Paramecium tetr...

Feature 1                                        
AAH56814     140 NETFVDnd--fiPFQDIRINHTVILDDPFDDP 169 zebrafish
XP_459815    155 NLSVVEnletrrLLKDIRITHTHNIYDPFPDP 186 Debaryomyces hansenii CBS767
EAL23123     145 NDAFTDke--grPLQNIRIRHVEILEDPFPDP 174 Cryptococcus neoformans var. neoformans B-3501A
bzub:AFR649W 149 SDVPRDlh--hlPRTDIRIRRAHILYDPFPDN 178 Eremothecium gossypii
NP_595894    147 NDAICDee--gqPYRDIRIKHTIILDDPFEDP 176 fission yeast
NP_492343    140 NEQLADtn--nrPFKDIRISHTIVLDDPFDED 169 nematode
BAD45991     140 SETYVDdk--grPFKDIRIKHTYVLDDPFDDP 169 Japanese rice
AAS75309     140 NEAYVDpk--nrPYKNIRIKHTHILDDPFDDP 169 thale cress
NP_651291    140 NDAIVDds--frPYQDIRITHTVVLEDPFPNP 169 fruit fly
XP_327465    151 NDAIVDer--ghPLVDIRIKHTVILDDPYPDP 180 Neurospora crassa
NP_624311    140 NETFVDkd--fvPYQDIRINHTVILDDPFDDP 169 human
XP_419663    140 NETFVDkd--fiPYQDIRINHTVILDDPFDDP 169 chicken
CAC35733     129 NRTHIDdd--grPLLNIRIKHTYILDDPFEDI 158 Paramecium tetraurelia

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