1K3C,1II2,1KHG


Conserved Protein Domain Family
PEPCK

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cd01919: PEPCK 
Click on image for an interactive view with Cn3D
Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate to yield phosphoenolpyruvate and carbon dioxide, using a nucleotide molecule (ATP or GTP) for the phosphoryl transfer, and has a strict requirement for divalent metal ions for activity. PEPCK's separate into two phylogenetic groups based on their nucleotide substrate specificity (the ATP-, and GTP-dependent groups).
Statistics
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PSSM-Id: 238900
Aligned: 3 rows
Threshold Bit Score: 757.541
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                        #                            
1K3C_A     21 HDIVYnp----sYDLLYQEELDpsltgyERGVLTn---lGAVAVDTGIFTGRSPKDKYIVRddttrdtfwwadkgkgknd 93  Escherichia coli
1II2_A      2 PTIHRnl----lSPELVQWALKi----eKDSRLTa---rGALAVMSYAKTGRSPLDKRIVDtddvrenv------dwgkv 64  Trypanosoma cruzi
1KHG_A     44 DHIHIcdgseeeNGRLLGQMEEe-----GILRRLkkydnCWLALTDPRDVARIESKTVIVTqeqrdtvpip--ktglsql 116 human
Feature 1                                                                                     
1K3C_A     94 nkPLSPETWQHLKGLVTrql-sgkRLFVVDAFCGa-NPDTRLSVRFITEVAWQAHFVKNMFIRPsdEELAGFk--pDFIV 169 Escherichia coli
1II2_A     65 nmKLSEESFARVRKIAKefldtreHLFVVDCFAGh-DERYRLKVRVFTTRPYHALFMRDMLIVPtpEELATFge-pDYVI 142 Trypanosoma cruzi
1KHG_A    117 grWMSEEDFEKAFNARFpgcmkgrTMYVIPFSMGplGSPLSKIGIELTDSPYVVASMRIMTRMGt-PVLEALgdgeFVKC 195 human
Feature 1                                               # #     ##                   #        
1K3C_A    170 MNGAKCtnpqwk-----eqglnsENFVAFNLTERMQLIGGTWYGG---EMKKGM-FSMMNYLLPLKGIASMHCSANVGEK 240 Escherichia coli
1II2_A    143 YNAGECkadpsi------pgltsTTCVALNFKTREQVILGTEYAG---EMKKGI-LTVMFELMPQMNHLCMHASANVGKQ 212 Trypanosoma cruzi
1KHG_A    196 LHSVGCplplqkplvnnwpcnpeLTLIAHLPDRREIISFGSGYGGnslLGKKCFaLRMASRLAKEEGWLAEHMLVLGITN 275 human
Feature 1                  #######                 ##                     # #        #        
1K3C_A    241 Gd----vAVFFGLSGTGKTTLStd------pkRRLIGDDEHGWDDDG-----VFNFEGGCYAKTIKLSKEAEPEIYNAIr 305 Escherichia coli
1II2_A    213 Gd----vTVFFGLSGTGKTTLSad------phRNLIGDDEHVWTDRG-----VFNIEGGCYAKAIGLNPKTEKDIYDAVr 277 Trypanosoma cruzi
1KHG_A    276 PegekkyLAAAFPSACGKTNLAmmnpslpgwkVECVGDDIAWMKFDAqghlrAINPENGFFGVAPGTSVKTNPNAIKTIq 355 human
Feature 1                                                          #                          
1K3C_A    306 rDALLENVTVRe-DGTIDFddgs-------------------------kteNTRVSYPIYHIDNIVKpvsk--aghATKV 357 Escherichia coli
1II2_A    278 fGAVAENCVLDkrTGEIDFydes-------------------------ickNTRVAYPLSHIEGALSkai---aghPKNV 329 Trypanosoma cruzi
1KHG_A    356 kNTIFTNVAETs-DGGVYWegideplasgvtitswknkewssedgepcahpNSRFCTPASQCPIIDAawespegvpIEGI 434 human
Feature 1                                                                                     
1K3C_A    358 IFLTADAfgVLPPVSRLt-ADQTQYHFLSGFTAKlagt-ergITEPTPTFSACFGAAFLSLHPTQYAEVLVKRMQaa--- 432 Escherichia coli
1II2_A    330 IFLTNDAfgVMPPVARLt-SAQAMFWFVMGYTANvpgveaggTRTARPIFSSCFGGPFLVRHATFYGEQLAEKMQkh--- 405 Trypanosoma cruzi
1KHG_A    435 IFGGRRPa-GVPLVYEAlsWQHGVFVGAAMRSEAtaa---aeHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQhpaak 510 human
Feature 1                          #  #  #                                                    
1K3C_A    433 gAQAYLVNTGwng-----tgkRISIKDTRAIIDAILNGSLDNAETFTLPmfnlAIPt--eLPgvdtkildprntyaspeq 505 Escherichia coli
1II2_A    406 nSRVWLLNTGyaggradrgakRMPLRVTRAIIDAIHDGTLDRTEYEEYPgwglHIPk--yVAkvpehllnprkawkdvrq 483 Trypanosoma cruzi
1KHG_A    511 lPKIFHVNWFrkdke--gkflWPGFGENSRVLEWMFNRIDGKASTKLTPi--gYIPkedaLNlkglghin---mmelfsi 583 human
Feature 1                                       
1K3C_A    506 wQEKAETLAKLFIDNFDKYtdt---paGAALVAA 536 Escherichia coli
1II2_A    484 fNETSKELVAMFQESFSARfaa---kaSQEMKSA 514 Trypanosoma cruzi
1KHG_A    584 sKEFWDKEVEDIEKYLVDQvnadlpceIEREILA 617 human

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