1NED,1OFI,1YYF


Conserved Protein Domain Family
protease_HslV
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cd01913: protease_HslV 
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Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the interior walls of the cavity. HslV shares significant sequence and structural similarity with the proteasomal beta-subunit and both are members of the Ntn-family of hydrolases. HslV has a nucleophilic threonine residue at its N-terminus that is exposed after processing of the propeptide and is directly involved in active site catalysis.
Links
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Statistics
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PSSM-Id: 238894
Aligned: 42 rows
Threshold Bit Score: 260.973
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active siteHslU subunit
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #               # #              #                                              
1NED_A        1 TTIVSVRRNGHVVIAGDGQATLGN-TVMKGNVKKVRRLYndkVIAGFAGGTADAFTLFELFERKLEMHQgHLVKAAVELA 79  Escherichia coli
1OFI_N        1 TTIVSVRRNGQVVVGGDGQVSLGN-TVMKGNARKVRRLYngkVLAGFAGGTADAFTLFELFERKLEMHQgHLLKSAVELA 79  Haemophilus infl...
1YYF_C        7 TTIFAVQHKGRSAMSGDGQVTFGQaVVMKHTARKVRKLFngkVLAGFAGSVADAFTLFEKFEAKLEEYNgNLKRAAVELA 86  Bacillus subtilis
P39070        7 TTIFAVQHKGRSAMSGDGQVTFGQaVVMKHTARKVRKLFngkVLAGFAGSVADAFTLFEKFEAKLEEYNgNLKRAAVELA 86  Bacillus subtilis
Q48734        2 TTICSVKYNGQTAIAGDGQVTLGKsIIAKTTAKKIRRIYhdqVVIGFAGGVADAVSLQEMLEGKLESYSgDLRRAAVEMA 81  Lactobacillus le...
Q8R9Y2        5 TTIVAVRRGDRVSVAGDGQVTFGDsTILKHGAKKIRRLYngeVIVGFAGSVADAMTLSQKFEEKLEQYGgNLKRAAVELA 84  Thermoanaerobact...
AAN75635      9 TTILCVRKSGKVAIGGDGQVSMGN-TVMKNTAKKIRRLYdgkILSGFAGSAADAFTLFELFEKKVQEFGgSLSRSAVELA 87  Leptospira borgp...
ZP_00560860   5 TTIVAVKKGDQVAMAGDGQVTMGQaTVMKHKARKVRRLFhgkVLAGFAGSVADAFTLFEKFENKLEEYQgNLQRAAVELA 84  Desulfitobacteri...
EAO23953      5 TTIIAVRKGQQTAIAGDGQVTLGQnTIMKQNATKIRRLYegkVIAGFAGAVADAFTLFAKFEEKLKQAGgNLSKAAVEIA 84  Syntrophomonas w...
YP_445762    37 TTVLGVRHNGQIALGSDGQATMNE-TVVKHKAEKVRSLYdgdILAGFAGSTADAFTLFERFEEKLQEYGgNVARAAVELA 115 Salinibacter rub...

Feature 1                                                    #                                  
1NED_A       80 KDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPe-nDLIAIGSGGPYAQAAARALLENte--lSAREIAEKALDIAG 156 Escherichia coli
1OFI_N       80 KDWRTDRALRKLEAMLIVADEKESLIITGIGDVVQPeedQILAIGSGGNYALSAARALVENte--lSAHEIVEKSLRIAG 157 Haemophilus infl...
1YYF_C       87 KEWRSDKVLRKLEAMLIVMNQDTLLLVSGTGEVIEPd-dGILAIGSGGNYALAAGRALKKHagesmSASEIARAALETAG 165 Bacillus subtilis
P39070       87 KEWRSDKVLRKLEAMLIVMNQDTLLLVSGTGEVIEPd-dGILAIGSGGNYALAAGRALKKHagesmSASEIARAALETAG 165 Bacillus subtilis
Q48734       82 QSWRKDQTLQKLEAMVIAFNDQDLLLISGNGEVLEPd-eSVVAIGSGGYYAQAAAVGMLRHas-gmTASEIAKEAVNIAA 159 Lactobacillus le...
Q8R9Y2       85 QEWRKDKILRKLEALLIAADKKDTLLISGTGEVIEPd-eDVIGIGSGGNYAMAAALALRYNtd--lDTEEIARKALEIAS 161 Thermoanaerobact...
AAN75635     88 REWRTDRMLRKLEALLIVADKEESFLISGTGDVISPd-eGVIAIGSGGSYALAAAKALYDHtd--lSAREIVESSMKIAA 164 Leptospira borgp...
ZP_00560860  85 KDWRMDKALRNLEALLIVADKQSMLLISGSGEVIEPd-dGIAAIGSGGNYALAAARALVKNtd--lQPAQLVQEAMEVAS 161 Desulfitobacteri...
EAO23953     85 REWRSDRILRRLEALLIVADAEKIFIVSGSGELIEPd-dGIAAIGSGGAYALAAARALNAFse--lNAREIAVESLKIAS 161 Syntrophomonas w...
YP_445762   116 KEWRTDKYLRRLEALLAVASPGELLLISGAGDVIEPd-dDIIAIGSGGSFALAASRALLQNaq-glTARDIVENGLSIAA 193 Salinibacter rub...

Feature 1                      
1NED_A      157 DICIYTNHFHTIEEL 171 Escherichia coli
1OFI_N      158 DICVFTNTNFTIEEL 172 Haemophilus influenzae Rd KW20
1YYF_C      166 EICVYTNDQIILEEL 180 Bacillus subtilis
P39070      166 EICVYTNDQIILEEL 180 Bacillus subtilis
Q48734      160 DIDVFTDHEIVTDEI 174 Lactobacillus leichmannii
Q8R9Y2      162 KICVYTNNNITVETL 176 Thermoanaerobacter tengcongensis
AAN75635    165 NICIYTNDHITLEEI 179 Leptospira borgpetersenii
ZP_00560860 162 SICVYTNDQIIVEEL 176 Desulfitobacterium hafniense DCB-2
EAO23953    162 GICVYTNEQISVEVI 176 Syntrophomonas wolfei subsp. wolfei str. Goettingen
YP_445762   194 DICIYTNHNRTIRDI 208 Salinibacter ruber DSM 13855

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