1WXQ


Conserved Protein Domain Family
Ygr210
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cd01899: Ygr210 
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Ygr210 GTPase
Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.
Links
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Statistics
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PSSM-Id: 206686
Aligned: 32 rows
Threshold Bit Score: 377.724
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity with GTPase Era.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            # ####                                                                   
1WXQ_A      3 IGVVGKPNVGKSTFFSAATLVDV-----EIANYPFTTIEANVGVTYaitdHPCKELGcspnpq----------------- 60   Pyrococcus horiko...
XP_806155 461 IGLIGKPSAGKSTFFNAVTDPDSeskaaKVAAFPFTTIEPNVSAGFgavfCPCCILStssspcdam-------------- 526  Trypanosoma cruzi
XP_829747 468 IGLIGKPSAGKSTFYNAVTNPDNeskaaRVAAFPFTTIDPNVGCGFgpifCPCSLSQpspsstgqcga------------ 535  Trypanosoma brucei
CAJ08843  466 IGLIGKPSAGKSTFFNAVTNPAVesdaaRVAAFPFTTIEPNIGAGLaplyCPCATLRaaavaragdgatdvaatagsars 545  Leishmania major
XP_723532   7 IGLVGKPSSGKSTTLNALTDANA-----KCGAFPFTTIDPNKATGYleidCACARFNkqdkckp---------------- 65   Candida albicans ...
P42942      7 IGIVGKPSSGKSTTLNSLTDAGA-----AVGAFPFTTIEPNQATGYlqveCACSRFGkedlckp---------------- 65   baker's yeast
XP_504169   7 IGIVGKPSSGKSTTLNSLTDATA-----KTGSFPFTTIDPNKATGYlqidCACARFKvqekckp---------------- 65   Yarrowia lipolyti...
XP_627533  21 IGCVGKPSSGKSTFFSSITDNPA-----KIGNYPFTTIEPNVGITHyiaeCPCKKYNvickpk----------------- 78   Cryptosporidium p...
CAD70888    7 IGLVGKPSAGKSSTLNSLTDASS-----KVGNFPFTTIDPQRAIGYlqidCACARYNvserckp---------------- 65   Neurospora crassa
AAT43437    4 IGIVGKPNAGKSTLFSAITQIDV-----DIADYPFTTIKPNVGISYikskCPHTEINvqcnpr----------------- 61   Picrophilus torri...

Feature 1                                                                                     
1WXQ_A     61 ---------------------nyeyrnGLALIPVKXVDVAGLVPGAHEGRGLGNKFLDDLRXASALIHVVDAtgktdpe- 118  Pyrococcus horiko...
XP_806155 527 ------------------yghvpvggaLCRRHPVIIKDVAGLVQGAYKGKGKGNQFLNDLCDASVLVHVVDGagatnadg 588  Trypanosoma cruzi
XP_829747 536 -----------------kyghvttfgaPHRRHPIVVKDVAGLVQGAYRGKGKGNRFLNDLCDADVLVHIVDGagatyadg 598  Trypanosoma brucei
CAJ08843  546 ssaalssglagdlcdatyghtralgsdRFRRHPVRVKDVAGLVQGAYQGKGKGNQFLNDLCDADVLVHVVDGaaateadg 625  Leishmania major
XP_723532  66 --------------------nygycrnGKRGVPIMLLDVAGLVPNAHLGRGLGNKFLSDLTEADCLIHIVDAsgttdae- 124  Candida albicans ...
P42942     66 --------------------nygwcskGKRHIPIKLLDVAGLVPGAHSGRGLGNKFLDDLRHADALIHVVDVsgttdae- 124  baker's yeast
XP_504169  66 --------------------nygtckdGRRFVPIMLLDVAGLVPGAHQGRGLGNKFLDDLRHADALIHVVDVsgttdae- 124  Yarrowia lipolyti...
XP_627533  79 ---------------------ygncnnGYRYVPIKMLDIAGLIPGAHLGNGLGNKFLDDLRHAHVLLHIIDIsgntnek- 136  Cryptosporidium p...
CAD70888   66 --------------------nygscvnGKRSVPIELLDVAGLVPGAHEGKGLGNKFLDDLRHADALIHVVDAsgttdae- 124  Neurospora crassa
AAT43437   62 ---------------------egkcidGTRYIPVEIIDVPGLIEGASEGKGMGNQFLDNIRDSDIIINLFDAs------- 113  Picrophilus torri...

Feature 1                                                                                     
1WXQ_A    119 -gqptdyhDPVEDIEFLEREIDYWIYGILSKGWDKFAKriklqKIKLESAIAEHLSGIGvnendvweax--hklnlpedp 195  Pyrococcus horiko...
XP_806155 589 sacppgtgSTCDDITWVRAEVHSWIYDNLRAKWGGIRRkpeklRTMFTGYRSPPSFVDGvlrymgits----eaelmsql 664  Trypanosoma cruzi
XP_829747 599 sacapgegSTFDDIMWVRGELHSWIYDNLRAQWAAVVRkplkiRTVFTGYHSPPSSIDAllrclgist----evelvrrl 674  Trypanosoma brucei
CAJ08843  626 tacapgqgSTMEDITWVRSEVHSWIYDNLRAKWTSLVRqptklRTMFSGYRSTPTFVDRvlrrvgian----eialtaml 701  Leishmania major
XP_723532 125 -gkatrgyDPLQDIEWLQDEIFQWILGNLKERWGSVVRrhigtKSSTLETMRQQLGGYVankkligdal--dlipdlppl 201  Candida albicans ...
P42942    125 -gkntrgyDPLNDIEWLQDEIRLWVEGNLKKRWGSIVRkhtatKSSIVDTLQAQFGGYGshapmiqkal--drlkglppl 201  baker's yeast
XP_504169 125 -gkntrgyDPVNDIEWLQDEIFRWIEGNLKEKWGSIVRrhtstKSHIVDTLQNQFSGYGsnkdivhra---idkltlppm 200  Yarrowia lipolyti...
XP_627533 137 -geyttnyNPINDHEWLRIEIEMWIFNNINSNWSSVVRksktsDISISKLLLNQFSGYGcnelmisklissmklkdsvdf 215  Cryptosporidium p...
CAD70888  125 -gkvtrgyDPSVDIAWLRSEIVAWIKGNLWEKWGSIKRrhiavKATAVETLQAQFSGYGstaavvartl--dklglkepl 201  Neurospora crassa
AAT43437  114 -------sDYKNDISMVRNEIIKWISSKIYDNWQKFSRkedasGDRLALKLLKKLATFGinekqveyli--tkvnmpqql 184  Picrophilus torri...

Feature 1                               ## #                          ###                     
1WXQ_A    196 TKWSQDDLLAFASEIRRVNKPXVIAANKADaasdeqikrl--vreeekrgyIVIPTSAAAELTLRKAAKAGFIEYip--- 270  Pyrococcus horiko...
XP_806155 665 PVWRQAELHRLVALYVRLRFPIVVALNKSDiqsvagelh----adlqrrypHEKFVPMSAKVECHLLRQSGLVEYvs--- 737  Trypanosoma cruzi
XP_829747 675 PAWGAAELHLLVATFVHLRFPIVVALNKADmrcaadklic--tlkerypneTLVQMSAKMECNLLFLRQVGAVRYvp--- 749  Trypanosoma brucei
CAJ08843  702 RTWGPPELHAFVALYVRLRFPMIVALNKADlstaadvaa---alrqaypheVFVLMTARIEWLALQLSRKGYVDYtp--- 775  Leishmania major
XP_723532 202 QDWDDEMLGKVVRAFMEVKFPTVLSLNKMDhpdadknvs---kiilkypksKAVLTSSITEVFLRKLAAQNYIKYd---- 274  Candida albicans ...
P42942    202 EKWDDEWITRVVKSFMMEKFPTVLALNKIDhpdadknvs---kimlkypdtKAVLTSAVTEVFLRKLKKQGFILYe---- 274  baker's yeast
XP_504169 201 EEWDDDKISEVVRAFTREKFPTVLALNKMDhpdadmnvs---kimkrhpdvPSVLTSAISEVFIRKLAKQGYVQYe---- 273  Yarrowia lipolyti...
XP_627533 216 SNWDKTNILDLVRQFIKIRFPFVLVLNKADimsessdsnivkfyekygsdhEIVVASSLAEYFIKKMVRQNYIKLvydsn 295  Cryptosporidium p...
CAD70888  202 EEWSEETVDRVVNAFTDEKFPTVIALNKIDhpdadknia---kiakmqdpnSIVLCSAISEIFLRKMAKQGYIKYt---- 274  Neurospora crassa
AAT43437  185 SVWTEDDVIELSNAILKYIKPVFDVGNKADllnes-----------nikklEYPVISAGYELALARAYRNGYIDRy---- 249  Picrophilus torri...

Feature 1                                                                                     
1WXQ_A    271 --gASEFKVLRdx---------------seKQKRALXVIKe----------KVLDr------fGSTGVQEVINRVVFDLL 317  Pyrococcus horiko...
XP_806155 738 --gDSSFQEKGssgd------------grgSLMSPMESMAl---------aEVRQffgsgrtpTTTGVQEVLAAALFRCP 794  Trypanosoma cruzi
XP_829747 750 --gDHSFEEVDgapanv-------tdavrkRAMKALVELR-----------EFFSpmh---pdTTTGVQAVLAAALSLCP 806  Trypanosoma brucei
CAJ08843  776 --gAASLSLKAdcgegad-----lekrvrqELHDVTSFFRtttssperlssSVLRl-------TTTGVQDVLAAAMEACG 841  Leishmania major
XP_723532 275 --sGTEFIDTIddlpddp-----dlkplddKLRNRIENIRd----------LVLYr------fGSTGVVQLLQAAADLLN 331  Candida albicans ...
P42942    275 --eGTEFVDTFedepdk-------lkplddKILNRIENIRd----------LVLYr------fGSTGVVQVLQAATDILG 329  baker's yeast
XP_504169 274 --eGTEFLDTAedlpdag------lkplddKLKERVENVRd----------LVLYr------fGSTGLVQILQAAANILE 329  Yarrowia lipolyti...
XP_627533 296 nynYSSFITSEdihneesh----glkliddKLKSRLENIKd----------MVLFr------hGVTGVQDAVNKAVDLLG 355  Cryptosporidium p...
CAD70888  275 --eGSEFVDTRedliadgdpdggglkeldeKNRNRIENLKd----------MVLYr------fGSTGVNQVLSKAAEILG 336  Neurospora crassa
AAT43437  250 ---SRDFKISDkc---------------ngQQRAVLNSIH-----------EFYE--------KNTMFDDVISGIVNSLG 292  Picrophilus torri...

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